Entity Details

Primary name LAG3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP18627
EntryNameLAG3_HUMAN
FullNameLymphocyte activation gene 3 protein
TaxID9606
Evidenceevidence at protein level
Length525
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesLAG3

GO terms

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GOName
GO:0002250 adaptive immune response
GO:0002270 plasmacytoid dendritic cell activation
GO:0003823 antigen binding
GO:0004888 transmembrane signaling receptor activity
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0007166 cell surface receptor signaling pathway
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0032703 negative regulation of interleukin-2 production
GO:0042289 MHC class II protein binding
GO:0045590 negative regulation of regulatory T cell differentiation
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0050776 regulation of immune response

Subcellular Location

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Subcellular Location
Cell membrane
Secreted

Domains

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DomainNameCategoryType
IPR003599 Immunoglobulin subtypeDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015621 Interleukin-1 receptor familyFamilyFamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
LAG3_HUMANCEBPZ_HUMANHPRD11592063 details
LAG3_HUMANCENPJ_HUMANHPRD11592063 details