Entity Details

Primary name DNLI1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP18858
EntryNameDNLI1_HUMAN
FullNameDNA ligase 1
TaxID9606
Evidenceevidence at protein level
Length919
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesLIG1

GO terms

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GOName
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0006266 DNA ligation
GO:0006273 lagging strand elongation
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006284 base-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0006298 mismatch repair
GO:0006310 DNA recombination
GO:0009653 anatomical structure morphogenesis
GO:0043231 intracellular membrane-bounded organelle
GO:0046872 metal ion binding
GO:0051301 cell division
GO:0071897 DNA biosynthetic process
GO:1903461 Okazaki fragment processing involved in mitotic DNA replication

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000977 DNA ligase, ATP-dependentFamilyFamily
IPR012308 DNA ligase, ATP-dependent, N-terminalDomainDomain
IPR012309 DNA ligase, ATP-dependent, C-terminalDomainDomain
IPR012310 DNA ligase, ATP-dependent, centralDomainDomain
IPR012340 Nucleic acid-binding, OB-foldFamilyHomologous superfamily
IPR016059 DNA ligase, ATP-dependent, conserved siteSiteConserved site
IPR036599 DNA ligase, ATP-dependent, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00290 BleomycinDrugbanksmall molecule