Entity Details

Primary name AMD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19021
EntryNameAMD_HUMAN
FullNamePeptidyl-glycine alpha-amidating monooxygenase
TaxID9606
Evidenceevidence at protein level
Length973
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesPAM

GO terms

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GOName
GO:0001519 peptide amidation
GO:0001666 response to hypoxia
GO:0001676 long-chain fatty acid metabolic process
GO:0004504 peptidylglycine monooxygenase activity
GO:0004598 peptidylamidoglycolate lyase activity
GO:0005507 copper ion binding
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007417 central nervous system development
GO:0007507 heart development
GO:0007595 lactation
GO:0008270 zinc ion binding
GO:0009268 response to pH
GO:0009404 toxin metabolic process
GO:0009986 cell surface
GO:0010043 response to zinc ion
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0018032 protein amidation
GO:0019901 protein kinase binding
GO:0022602 ovulation cycle process
GO:0030658 transport vesicle membrane
GO:0030667 secretory granule membrane
GO:0031418 L-ascorbic acid binding
GO:0032355 response to estradiol
GO:0032956 regulation of actin cytoskeleton organization
GO:0042476 odontogenesis
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043204 perikaryon
GO:0046688 response to copper ion
GO:0048471 perinuclear region of cytoplasm
GO:0050708 regulation of protein secretion
GO:0051384 response to glucocorticoid
GO:0060135 maternal process involved in female pregnancy
GO:0060173 limb development
GO:0062112 fatty acid primary amide biosynthetic process
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasmic vesicle
Membrane
Secreted

Domains

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DomainNameCategoryType
IPR000323 Copper type II, ascorbate-dependent monooxygenase, N-terminalDomainDomain
IPR000720 Peptidylglycine alpha-hydroxylating monooxygenase/peptidyl-hydroxyglycine alpha-amidating lyaseFamilyFamily
IPR001258 NHL repeatRepeatRepeat
IPR008977 PHM/PNGase F domain superfamilyFamilyHomologous superfamily
IPR011042 Six-bladed beta-propeller, TolB-likeFamilyHomologous superfamily
IPR013017 NHL repeat, subgroupRepeatRepeat
IPR014783 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved siteSiteConserved site
IPR014784 Copper type II, ascorbate-dependent monooxygenase-like, C-terminalFamilyHomologous superfamily
IPR020611 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved siteSiteConserved site
IPR024548 Copper type II ascorbate-dependent monooxygenase, C-terminalDomainDomain
IPR036939 Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00126 Ascorbic acidDrugbanksmall molecule
DB02598 N-Alpha-Acetyl-3,5-DiiodotyrosylglycineDrugbanksmall molecule
DB04150 N-alpha-Acetyl-3,5-diiodotyrosyl-D-threonineDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule