Entity Details

Primary name NDUV2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19404
EntryNameNDUV2_HUMAN
FullNameNADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length249
SequenceStatuscomplete
DateCreated1990-11-01
DateModified2021-06-02

Ontological Relatives

GenesNDUFV2

GO terms

Show/Hide Table
GOName
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005747 mitochondrial respiratory chain complex I
GO:0005829 cytosol
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0007399 nervous system development
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0009055 electron transfer activity
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0046872 metal ion binding
GO:0048738 cardiac muscle tissue development
GO:0051537 2 iron, 2 sulfur cluster binding

Subcellular Location

Show/Hide Table
Subcellular Location
Mitochondrion inner membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR002023 NADH-quinone oxidoreductase subunit E-likeFamilyFamily
IPR036249 Thioredoxin-like superfamilyFamilyHomologous superfamily
IPR041921 NADH-quinone oxidoreductase subunit E, N-terminalFamilyHomologous superfamily
IPR042128 NuoE domainDomainDomain

Diseases

Show/Hide Table
Disease IDSourceNameDescription
618229 OMIMMitochondrial complex I deficiency, nuclear type 7 (MC1DN7)A form of mitochondrial complex I deficiency, the most common biochemical signature of mitochondrial disorders, a group of highly heterogeneous conditions characterized by defective oxidative phosphorylation, which collectively affects 1 in 5-10000 live births. Clinical disorders have variable severity, ranging from lethal neonatal disease to adult-onset neurodegenerative disorders. Phenotypes include macrocephaly with progressive leukodystrophy, non-specific encephalopathy, cardiomyopathy, myopathy, liver disease, Leigh syndrome, Leber hereditary optic neuropathy, and some forms of Parkinson disease. MC1DN7 transmission pattern is consistent with autosomal recessive inheritance. The disease is caused by variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB00157 NADHDrugbanksmall molecule

Interactions

85 interactions

InteractorPartnerSourcesPublicationsLink
NDUV2_HUMANDPYL1_HUMANBioGRID, HPRD, IntAct16169070 details
NDUV2_HUMANKAT5_HUMANBioGRID, HPRD, IntAct16169070 details
NDUV2_HUMANSP110_HUMANBioGRID, HPRD, IntAct16169070 details
NDUV2_HUMANF1142_HUMANBioGRID, IntAct32296183 details
NDUV2_HUMANGOLM1_HUMANBioGRID, IntAct32296183 details
NDUV2_HUMANRASF1_HUMANBioGRID, IntAct26186194 28514442 32814053 details
NDUV2_HUMANCCNC_HUMANBioGRID, IntAct32296183 32814053 details
NDUV2_HUMANOCLN_HUMANIntAct32814053 details
NDUV2_HUMANAP2B1_HUMANIntAct32814053 details
NDUV2_HUMANFYN_HUMANIntAct32814053 details
NDUV2_HUMANZNF19_HUMANIntAct32814053 details
NDUV2_HUMANKT33B_HUMANIntAct32814053 details
NDUV2_HUMANFANCG_HUMANIntAct32814053 details
NDUV2_HUMANHNRPK_HUMANIntAct32814053 details
NDUV2_HUMANSORL_HUMANIntAct32814053 details
NDUV2_HUMANOTX1_HUMANIntAct32814053 details
NDUV2_HUMANCTNB1_HUMANIntAct32814053 details
NDUV2_HUMANNP1L3_HUMANIntAct32814053 details
NDUV2_HUMANTHIO_HUMANIntAct32814053 details
NDUV2_HUMANSMRD1_HUMANIntAct32814053 details
NDUV2_HUMANCALM2_HUMANIntAct32814053 details
NDUV2_HUMANNHRF3_HUMANIntAct32814053 details
NDUV2_HUMANCRLF3_HUMANIntAct32814053 details
NDUV2_HUMANWWOX_HUMANIntAct32814053 details
NDUV2_HUMANNVL_HUMANIntAct32814053 details
NDUV2_HUMANVP26A_HUMANIntAct32814053 details
NDUV2_HUMANST4A1_HUMANIntAct32814053 details
NDUV2_HUMANSCAR3_HUMANIntAct32814053 details
NDUV2_HUMANSNF5_HUMANIntAct32814053 details
NDUV2_HUMANPCSK7_HUMANIntAct32814053 details
NDUV2_HUMANMSRB2_HUMANIntAct32814053 details
NDUV2_HUMANKLH20_HUMANIntAct32814053 details
NDUV2_HUMANBRK1_HUMANIntAct32814053 details
NDUV2_HUMANDNJA3_HUMANBioGRID, IntAct32814053 33957083 details
NDUV2_HUMANPIAS1_HUMANIntAct32814053 details
NDUV2_HUMANPHF19_HUMANIntAct32814053 details
NDUV2_HUMANRN112_HUMANIntAct32814053 details
NDUV2_HUMANOTU7B_HUMANIntAct32814053 details
NDUV2_HUMANTHAP1_HUMANIntAct32814053 details
NDUV2_HUMANIF2B_HUMANIntAct32814053 details
NDUV2_HUMANRBM11_HUMANIntAct32814053 details
NDUV2_HUMANRASF5_HUMANIntAct32814053 details
NDUV2_HUMANASIC4_HUMANIntAct32814053 details
NDUV2_HUMANCSN3_HUMANIntAct32814053 details
NDUV2_HUMANASB3_HUMANIntAct32814053 details
NDUV2_HUMANTUT7_HUMANIntAct32814053 details
NDUV2_HUMANCREL1_HUMANIntAct32814053 details
NDUV2_HUMANZN232_HUMANIntAct32814053 details
NDUV2_HUMANATLA1_HUMANIntAct32814053 details
NDUV2_HUMANH32_HUMANIntAct32814053 details
NDUV2_HUMANWDR61_HUMANIntAct32814053 details
NDUV2_HUMANZN410_HUMANIntAct32814053 details
NDUV2_HUMANNSMF_HUMANIntAct32814053 details
NDUV2_HUMANMET27_HUMANIntAct32814053 details
NDUV2_HUMANSAMD3_HUMANIntAct32814053 details
NDUV2_HUMANTRI69_HUMANIntAct32814053 details
NDUV2_HUMANRAB38_HUMANIntAct32814053 details
NDUV2_HUMANVSX2_HUMANIntAct32814053 details
NDUV2_HUMANPLB1_HUMANIntAct32814053 details
NDUV2_HUMANPPR21_HUMANIntAct32814053 details
NDUV2_HUMANSLU7_HUMANIntAct32814053 details
NDUV2_HUMANA4_HUMANIntAct32814053 details
NDUV2_HUMANSPA2L_HUMANIntAct32814053 details
NDUV2_HUMANLENG8_HUMANIntAct32814053 details
NDUV2_HUMANJADE3_HUMANIntAct32814053 details
NDUV2_HUMANLNX1_HUMANIntAct32814053 details
NDUV2_HUMANPP16A_HUMANIntAct32814053 details
NDUV2_HUMANLEG9C_HUMANIntAct32814053 details
NDUV2_HUMANTRI74_HUMANIntAct32814053 details
NDUV2_HUMANSPT22_HUMANIntAct32814053 details
NDUV2_HUMANZSC22_HUMANIntAct32814053 details
NDUV2_HUMANAPI5_HUMANIntAct32814053 details
NDUV2_HUMANSPRE2_HUMANIntAct32814053 details
NDUV2_HUMANFOXA2_HUMANIntAct32814053 details
NDUV2_HUMANZN444_HUMANIntAct32814053 details
NDUV2_HUMANSPRE1_HUMANIntAct32814053 details
NDUV2_HUMANOTUB1_HUMANIntAct32814053 details
NDUV2_HUMANRN183_HUMANIntAct32814053 details
NDUV2_HUMANPACRL_HUMANIntAct32814053 details
NDUV2_HUMANRAB3I_HUMANIntAct32814053 details
NDUV2_HUMANH2A3_HUMANIntAct32814053 details
NDUV2_HUMANWDR83_HUMANIntAct32814053 details
NDUV2_HUMANMAGA2_HUMANIntAct32814053 details
NDUV2_HUMANTBB5_HUMANIntAct32814053 details
NDUV2_HUMANHSC20_HUMANBioGRID, IntAct28380382 33957083 details