Entity Details

Primary name CP7A1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP22680
EntryNameCP7A1_HUMAN
FullNameCytochrome P450 7A1
TaxID9606
Evidenceevidence at protein level
Length504
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesCYP7A1

GO terms

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GOName
GO:0005506 iron ion binding
GO:0005789 endoplasmic reticulum membrane
GO:0006699 bile acid biosynthetic process
GO:0006707 cholesterol catabolic process
GO:0008123 cholesterol 7-alpha-monooxygenase activity
GO:0008395 steroid hydroxylase activity
GO:0010468 regulation of gene expression
GO:0015721 bile acid and bile salt transport
GO:0016021 integral component of membrane
GO:0016125 sterol metabolic process
GO:0019222 regulation of metabolic process
GO:0020037 heme binding
GO:0032966 negative regulation of collagen biosynthetic process
GO:0033782 24-hydroxycholesterol 7alpha-hydroxylase activity
GO:0038183 bile acid signaling pathway
GO:0042632 cholesterol homeostasis
GO:0043231 intracellular membrane-bounded organelle
GO:0045471 response to ethanol
GO:0045542 positive regulation of cholesterol biosynthetic process
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0070857 regulation of bile acid biosynthetic process
GO:0071333 cellular response to glucose stimulus
GO:0071397 cellular response to cholesterol

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002403 Cytochrome P450, E-class, group IVFamilyFamily
IPR017972 Cytochrome P450, conserved siteSiteConserved site
IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-typeFamilyFamily
IPR030681 Cholesterol 7-alpha-monooxygenaseFamilyFamily
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Interactions

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