Entity Details

Primary name KS6B1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23443
EntryNameKS6B1_HUMAN
FullNameRibosomal protein S6 kinase beta-1
TaxID9606
Evidenceevidence at protein level
Length525
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesRPS6KB1

GO terms

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GOName
GO:0000082 G1/S transition of mitotic cell cycle
GO:0001662 behavioral fear response
GO:0003009 skeletal muscle contraction
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004711 ribosomal protein S6 kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007281 germ cell development
GO:0007568 aging
GO:0007584 response to nutrient
GO:0007616 long-term memory
GO:0009408 response to heat
GO:0009611 response to wounding
GO:0009612 response to mechanical stimulus
GO:0009636 response to toxic substance
GO:0009749 response to glucose
GO:0009986 cell surface
GO:0014732 skeletal muscle atrophy
GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation
GO:0014911 positive regulation of smooth muscle cell migration
GO:0016477 cell migration
GO:0018105 peptidyl-serine phosphorylation
GO:0030165 PDZ domain binding
GO:0031667 response to nutrient levels
GO:0031929 TOR signaling
GO:0032496 response to lipopolysaccharide
GO:0032869 cellular response to insulin stimulus
GO:0033574 response to testosterone
GO:0033762 response to glucagon
GO:0034612 response to tumor necrosis factor
GO:0042277 peptide binding
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043066 negative regulation of apoptotic process
GO:0043201 response to leucine
GO:0043491 protein kinase B signaling
GO:0044539 long-chain fatty acid import into cell
GO:0045202 synapse
GO:0045471 response to ethanol
GO:0045727 positive regulation of translation
GO:0045931 positive regulation of mitotic cell cycle
GO:0045948 positive regulation of translational initiation
GO:0046324 regulation of glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048471 perinuclear region of cytoplasm
GO:0048633 positive regulation of skeletal muscle tissue growth
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051721 protein phosphatase 2A binding
GO:0071346 cellular response to interferon-gamma
GO:0071363 cellular response to growth factor stimulus
GO:0071549 cellular response to dexamethasone stimulus
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell junction
Cytoplasm
Mitochondrion
Mitochondrion outer membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016238 Ribosomal protein S6 kinaseFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain

Diseases

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Interactions

82 interactions

InteractorPartnerSourcesPublicationsLink
KS6B1_HUMANCOASY_HUMANBioGRID, HPRD, MINT15589845 details
KS6B1_HUMANTAU_HUMANBioGRID, HPRD, MINT16364302 17512525 details
KS6B1_HUMANPDK1_HUMANBioGRID, HPRD, MINT11279232 11733037 17110931 details
KS6B1_HUMANEIF3B_HUMANBioGRID, IntAct, UniProt16286006 18423201 21986499 24396066 details
KS6B1_HUMANKI3L1_HUMANBioGRID, IntAct21988832 details
KS6B1_HUMANMK08_HUMANBioGRID, HPRD, IntAct11279232 21988832 23816567 details
KS6B1_HUMANTETN_HUMANBioGRID, MINT21900206 details
KS6B1_HUMANDPPA4_HUMANBioGRID, MINT21900206 details
KS6B1_HUMANGLI1_HUMANIntAct22439934 details
KS6B1_HUMANRICTR_HUMANBioGRID, IntAct15809305 25241761 25273559 details
KS6B1_HUMANMAD1_HUMANBioGRID, DIP18451027 details
KS6B1_HUMANRPTOR_HUMANBioGRID, HPRD, IntAct12150926 12604610 15809305 16183647 16837165 19402821 21071439 21795849 22493283 23184942 25273559 26348909 details
KS6B1_HUMANAPLP2_HUMANIntAct32814053 details
KS6B1_HUMANP85A_HUMANIntAct32814053 details
KS6B1_HUMANUNG_HUMANIntAct32814053 details
KS6B1_HUMANA4_HUMANBioGRID, IntAct21832049 32814053 details
KS6B1_HUMANCSK2B_HUMANBioGRID, HPRD16895915 details
KS6B1_HUMANMTOR_HUMANBioGRID, HPRD10567431 10971657 11279232 11914378 12150925 12150926 12604610 12718876 14679009 15066126 15760907 15809305 15854902 15896331 15899889 15905173 16183647 16922504 17386266 18505677 22544753 25738361 28270148 9465032 details
KS6B1_HUMANACTS_HUMANBioGRID15149849 details
KS6B1_HUMANBTK_HUMANBioGRID16640565 details
KS6B1_HUMANCSK21_HUMANBioGRID16895915 details
KS6B1_HUMANLYN_HUMANBioGRID16640565 details
KS6B1_HUMANSRC_HUMANBioGRID16640565 details
KS6B1_HUMANKSYK_HUMANBioGRID16640565 details
KS6B1_HUMANPDIP3_HUMANBioGRID, HPRD15341740 details
KS6B1_HUMANEIF3F_HUMANBioGRID16286006 24396066 details
KS6B1_HUMANEF2K_HUMANBioGRID, HPRD11171059 11500364 14709557 15024086 details
KS6B1_HUMANRBX1_HUMANBioGRID18279656 details
KS6B1_HUMANEP300_HUMANBioGRID19961954 details
KS6B1_HUMANKAT2B_HUMANBioGRID19961954 details
KS6B1_HUMANNEDD4_HUMANBioGRID19953087 details
KS6B1_HUMANRS6_HUMANBioGRID, HPRD11438723 12668683 12867426 16810323 17693255 21460630 details
KS6B1_HUMANIRS1_HUMANBioGRID18498745 23045529 details
KS6B1_HUMANRMP_HUMANBioGRID21397856 details
KS6B1_HUMANRHEB_HUMANBioGRID18550814 details
KS6B1_HUMANNR1I2_HUMANBioGRID19171678 details
KS6B1_HUMANKS6B1_HUMANBioGRID24396066 details
KS6B1_HUMANDPTOR_HUMANBioGRID22017876 details
KS6B1_HUMANPI42A_HUMANBioGRID12747804 details
KS6B1_HUMANFBX7_HUMANBioGRID27503909 details
KS6B1_HUMANMXI1_HUMANBioGRID29507620 details
KS6B1_HUMANPGFRB_HUMANBioGRID16640565 details
KS6B1_HUMANUBP11_HUMANBioGRID29483509 details
KS6B1_HUMANTBK1_HUMANBioGRID28716898 details
KS6B1_HUMANGRIA1_HUMANBioGRID24706758 details
KS6B1_HUMANNEB2_HUMANHPRD9653190 details
KS6B1_HUMANNEB1_HUMANHPRD12052877 9653190 details
KS6B1_HUMANPDPK1_HUMANBioGRID, HPRD, MINT10601311 11438723 32876514 9271440 9427642 9445476 details
KS6B1_HUMANAKT1_HUMANBioGRID, HPRD, IntAct, MINT11438723 15149849 25241761 details
KS6B1_HUMANCDC42_HUMANHPRD, MINT11438723 details
KS6B1_HUMANNCBP1_HUMANBioGRID, HPRD, IntAct10973943 18423201 details
KS6B1_HUMAN2ABB_HUMANIntAct21075311 details
KS6B1_HUMANHS90B_HUMANIntAct22939624 details
KS6B1_HUMANSTK11_HUMANBioGRID, HPRD, IntAct11297520 11853558 25241761 details
KS6B1_HUMANIER5_HUMANMINT26496226 details
KS6B1_HUMANTRAF4_HUMANBioGRID, HPRD12801526 25738361 details
KS6B1_HUMAN2ABA_HUMANBioGRID10200280 16899564 details
KS6B1_HUMANKPCZ_HUMANBioGRID16931574 details
KS6B1_HUMANEIF3C_HUMANBioGRID16286006 details
KS6B1_HUMANTERT_HUMANBioGRID, HPRD15843522 details
KS6B1_HUMANXPO1_HUMANBioGRID, HPRD16895915 details
KS6B1_HUMANMDM2_HUMANBioGRID20657550 details
KS6B1_HUMANNFAC1_HUMANBioGRID22113269 details
KS6B1_HUMANEIF3H_HUMANBioGRID16286006 details
KS6B1_HUMANSQSTM_HUMANBioGRID21981924 details
KS6B1_HUMANSIN1_HUMANBioGRID17043309 details
KS6B1_HUMANPLD2_HUMANBioGRID16837165 details
KS6B1_HUMANSTAT1_HUMANBioGRID19553685 details
KS6B1_HUMANTRIB2_HUMANBioGRID24089522 details
KS6B1_HUMANIRS2_HUMANBioGRID27742835 details
KS6B1_HUMANAGR2_HUMANBioGRID30575818 details
KS6B1_HUMANRAC1_HUMANHPRD11438723 details
KS6B1_HUMAN4EBP1_HUMANHPRD11438723 details
KS6B1_HUMANNEK6_HUMANHPRD11516946 12023960 details
KS6B1_HUMANPP2AA_HUMANHPRD10200280 11438723 16109716 16899564 details
KS6B1_HUMANCDK1_HUMANHPRD12586835 9271440 details
KS6B1_HUMANMK01_HUMANHPRD11279232 12054624 details
KS6B1_HUMANIF4B_HUMANHPRD16763566 details
KS6B1_HUMANPK3CA_HUMANHPRD11279232 details
KS6B1_HUMANMK03_HUMANHPRD11279232 details
KS6B1_HUMANMK09_HUMANHPRD11279232 details
KS6B1_HUMANPIN1_HUMANHPRD19168580 details