Entity Details

Primary name TNFL4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23510
EntryNameTNFL4_HUMAN
FullNameTumor necrosis factor ligand superfamily member 4
TaxID9606
Evidenceevidence at protein level
Length183
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesTNFSF4

GO terms

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GOName
GO:0001819 positive regulation of cytokine production
GO:0002215 defense response to nematode
GO:0002526 acute inflammatory response
GO:0002639 positive regulation of immunoglobulin production
GO:0002726 positive regulation of T cell cytokine production
GO:0002819 regulation of adaptive immune response
GO:0002830 positive regulation of type 2 immune response
GO:0002891 positive regulation of immunoglobulin mediated immune response
GO:0005102 signaling receptor binding
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007165 signal transduction
GO:0008284 positive regulation of cell population proliferation
GO:0009615 response to virus
GO:0009986 cell surface
GO:0032689 negative regulation of interferon-gamma production
GO:0032700 negative regulation of interleukin-17 production
GO:0032722 positive regulation of chemokine production
GO:0032729 positive regulation of interferon-gamma production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032736 positive regulation of interleukin-13 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032813 tumor necrosis factor receptor superfamily binding
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0035709 memory T cell activation
GO:0035712 T-helper 2 cell activation
GO:0035713 response to nitrogen dioxide
GO:0042102 positive regulation of T cell proliferation
GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043382 positive regulation of memory T cell differentiation
GO:0043433 negative regulation of DNA-binding transcription factor activity
GO:0045590 negative regulation of regulatory T cell differentiation
GO:0045626 negative regulation of T-helper 1 cell differentiation
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050871 positive regulation of B cell activation
GO:0071222 cellular response to lipopolysaccharide
GO:0071380 cellular response to prostaglandin E stimulus
GO:1900281 positive regulation of CD4-positive, alpha-beta T cell costimulation
GO:2000572 positive regulation of interleukin-4-dependent isotype switching to IgE isotypes

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR006052 Tumour necrosis factor domainDomainDomain
IPR008983 Tumour necrosis factor-like domain superfamilyFamilyHomologous superfamily
IPR021184 Tumour necrosis factor, conserved siteSiteConserved site
IPR042338 Tumor necrosis factor ligand superfamily member 4FamilyFamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
TNFL4_HUMANTNR4_HUMANDIP, HPRD12134113 16905106 details
TNFL4_HUMANTRAF2_HUMANHPRD9418902 details