Entity Details

Primary name SAHH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23526
EntryNameSAHH_HUMAN
FullNameAdenosylhomocysteinase
TaxID9606
Evidenceevidence at protein level
Length432
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesAHCY

GO terms

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GOName
GO:0000096 sulfur amino acid metabolic process
GO:0001666 response to hypoxia
GO:0002439 chronic inflammatory response to antigenic stimulus
GO:0004013 adenosylhomocysteinase activity
GO:0005634 nucleus
GO:0005829 cytosol
GO:0006730 one-carbon metabolic process
GO:0007584 response to nutrient
GO:0019510 S-adenosylhomocysteine catabolic process
GO:0030554 adenyl nucleotide binding
GO:0032259 methylation
GO:0033353 S-adenosylmethionine cycle
GO:0042470 melanosome
GO:0042745 circadian sleep/wake cycle
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0051287 NAD binding
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm
Melanosome

Domains

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DomainNameCategoryType
IPR000043 Adenosylhomocysteinase-likeFamilyFamily
IPR015878 S-adenosyl-L-homocysteine hydrolase, NAD binding domainDomainDomain
IPR020082 S-adenosyl-L-homocysteine hydrolase, conserved siteSiteConserved site
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily
IPR042172 Adenosylhomocysteinase-like superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
613752 OMIMHypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)A metabolic disorder characterized by hypermethioninemia associated with failure to thrive, mental and motor retardation, facial dysmorphism with abnormal hair and teeth, and myocardiopathy. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB03216 (1'R,2'S)-9-(2-Hydroxy-3'-Keto-Cyclopenten-1-yl)AdenineDrugbanksmall molecule
DB03273 3'-Oxo-AdenosineDrugbanksmall molecule
DB03769 D-EritadenineDrugbanksmall molecule
DB09130 CopperDrugbanksmall molecule