Entity Details

Primary name RPB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP24928
EntryNameRPB1_HUMAN
FullNameDNA-directed RNA polymerase II subunit RPB1
TaxID9606
Evidenceevidence at protein level
Length1970
SequenceStatuscomplete
DateCreated1992-03-01
DateModified2021-06-02

Ontological Relatives

GenesPOLR2A

GO terms

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GOName
GO:0000398 mRNA splicing, via spliceosome
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0003968 RNA-directed 5'-3' RNA polymerase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006351 transcription, DNA-templated
GO:0006353 DNA-templated transcription, termination
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006370 7-methylguanosine mRNA capping
GO:0008022 protein C-terminus binding
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0019900 kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0033120 positive regulation of RNA splicing
GO:0042795 snRNA transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048239 negative regulation of DNA recombination at telomere
GO:0050434 positive regulation of viral transcription
GO:0060964 regulation of gene silencing by miRNA
GO:1990841 promoter-specific chromatin binding

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000684 RNA polymerase II, heptapeptide repeat, eukaryoticRepeatRepeat
IPR000722 RNA polymerase, alpha subunitDomainDomain
IPR006592 RNA polymerase, N-terminalDomainDomain
IPR007066 RNA polymerase Rpb1, domain 3DomainDomain
IPR007073 RNA polymerase Rpb1, domain 7DomainDomain
IPR007075 RNA polymerase Rpb1, domain 6DomainDomain
IPR007080 RNA polymerase Rpb1, domain 1DomainDomain
IPR007081 RNA polymerase Rpb1, domain 5DomainDomain
IPR007083 RNA polymerase Rpb1, domain 4DomainDomain
IPR038120 RNA polymerase Rpb1, funnel domain superfamilyFamilyHomologous superfamily
IPR038593 RNA polymerase Rpb1, domain 7 superfamilyFamilyHomologous superfamily
IPR042102 RNA polymerase Rpb1, domain 3 superfamilyFamilyHomologous superfamily

Diseases

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Interactions

249 interactions

InteractorPartnerSourcesPublicationsLink
RPB1_HUMANSPT5H_HUMANBioGRID, DIP, HPRD, IntAct10075709 10454543 11940650 18197258 21880767 22939629 24814348 25416956 26344197 26496610 29395067 9450929 details
RPB1_HUMANASB6_HUMANBioGRID, IntAct28514442 32296183 details
RPB1_HUMANRPAB1_HUMANBioGRID, DIP, HPRD, IntAct, MINT19240132 22939629 24981860 26344197 27193682 28514442 9201987 details
RPB1_HUMANCDK7_HUMANBioGRID, DIP11278802 15009212 15282296 15328539 15530371 16327805 18391197 20106982 22379099 23064645 32355176 8692842 9311822 details
RPB1_HUMANCDK9_HUMANBioGRID, DIP, HPRD11278802 11575923 12036313 12052871 12591939 12861003 14580347 14627702 15009212 15169877 15328539 15713661 16735508 17234882 18391197 18566585 20106982 21030982 21873227 22379099 22592529 23064645 24837678 26659056 details
RPB1_HUMANBRCA1_HUMANBioGRID, HPRD10725406 11504724 12955082 14506230 15886201 18197258 22990118 25184681 27583302 29180510 29513652 9159119 details
RPB1_HUMANRPAB3_HUMANBioGRID, HPRD17283126 19240132 24981860 26344197 30349055 9201987 details
RPB1_HUMANZNF74_HUMANBioGRID, HPRD11313019 9346935 details
RPB1_HUMANHNRPU_HUMANBioGRID10490622 15711563 18710935 21235343 details
RPB1_HUMANSETD2_HUMANBioGRID16118227 24462114 details
RPB1_HUMANCSK21_HUMANBioGRID15282296 25252977 details
RPB1_HUMANSSU72_HUMANBioGRID20861839 details
RPB1_HUMANCTDP1_HUMANBioGRID, HPRD, MINT12036313 12560496 12591939 14576432 14576433 9159119 details
RPB1_HUMANWWOX_HUMANBioGRID, MINT16055720 24550385 details
RPB1_HUMANPAF1_HUMANBioGRID, IntAct, UniProt15923622 16024656 16491129 20178742 24360965 24837678 details
RPB1_HUMANRECQ5_HUMANBioGRID, DIP18562274 19270065 20705653 21402780 23748380 24981860 27502483 32900933 details
RPB1_HUMANRPB3_HUMANBioGRID, DIP, HPRD18562274 19240132 22939629 24981860 26344197 34079125 9201987 details
RPB1_HUMANCDK8_HUMANBioGRID, HPRD11278802 15009212 15328539 22379099 24981860 8700522 9443979 9710619 details
RPB1_HUMANNEDD4_HUMANBioGRID10490634 16055720 17996703 details
RPB1_HUMANRPB2_HUMANBioGRID19240132 22939629 24981860 26344197 31048545 details
RPB1_HUMANKMT2D_HUMANBioGRID16199523 details
RPB1_HUMANTTK_HUMANBioGRID9311822 details
RPB1_HUMANSAFB1_HUMANHPRD9671816 details
RPB1_HUMANRPAB2_HUMANBioGRID, HPRD, IntAct19240132 24981860 26344197 26496610 9201987 details
RPB1_HUMANRPB7_HUMANBioGRID, HPRD, IntAct19240132 24981860 26186194 26344197 26496610 28514442 9201987 details
RPB1_HUMANSMN_HUMANBioGRID, DIP, HPRD11149922 26700805 details
RPB1_HUMANKAT2B_HUMANBioGRID18710935 9710619 details
RPB1_HUMANVHL_HUMANBioGRID12604794 18285459 28775317 30349055 details
RPB1_HUMANGRB2_HUMANBioGRID, IntAct18624398 details
RPB1_HUMANLEO1_HUMANBioGRID, UniProt16024656 20178742 details
RPB1_HUMANNELFA_HUMANBioGRID, IntAct, UniProt12612062 26496610 details
RPB1_HUMANIFTAP_HUMANBioGRID, IntAct18433331 details
RPB1_HUMANRPAB4_HUMANBioGRID24981860 26344197 9201987 details
RPB1_HUMANTCEA1_HUMANBioGRID, DIP, HPRD, IntAct12914699 16916636 17643375 20178742 20562857 22939629 23748380 9305922 9765293 details
RPB1_HUMANRPB4_HUMANBioGRID, HPRD, IntAct, MINT10567706 22939629 24981860 26344197 26700805 28514442 details
RPB1_HUMANTF2H4_HUMANBioGRID9159119 details
RPB1_HUMANCTDS1_HUMANBioGRID, HPRD12721286 details
RPB1_HUMANCTCF_HUMANBioGRID, HPRD12054881 17210645 21880767 details
RPB1_HUMANITCH_HUMANBioGRID, HPRD16055720 26508657 details
RPB1_HUMANCSTF1_HUMANBioGRID, HPRD11459828 29180510 9002523 details
RPB1_HUMANMAT1_HUMANBioGRID15530371 16327805 details
RPB1_HUMANH12_HUMANBioGRID24360965 details
RPB1_HUMANTIF1B_HUMANBioGRID29955894 32402252 32900933 details
RPB1_HUMANTBP_HUMANBioGRID9002523 9159119 9311784 details
RPB1_HUMANT2FA_HUMANBioGRID12591939 15711563 17643375 22939629 30415952 9121429 9159119 9710619 details
RPB1_HUMANRPAB5_HUMANBioGRID, HPRD24981860 26344197 9201987 details
RPB1_HUMANSND1_HUMANBioGRID, HPRD12234934 details
RPB1_HUMANCSTF3_HUMANBioGRID10454562 11459828 9002523 details
RPB1_HUMANBARD1_HUMANBioGRID, HPRD12154023 22990118 29180510 details
RPB1_HUMANATM_HUMANBioGRID24957606 9168116 details
RPB1_HUMANELOA1_HUMANBioGRID16957778 19037258 details
RPB1_HUMANVDR_HUMANBioGRID10753860 15890193 15919092 details
RPB1_HUMANTF2H1_HUMANBioGRID10454562 15282296 32355176 8934526 details
RPB1_HUMANMYH6_HUMANBioGRID29187741 details
RPB1_HUMANTAF11_HUMANBioGRID15502823 9159119 details
RPB1_HUMANT2EA_HUMANBioGRID7926747 9159119 details
RPB1_HUMANERCC5_HUMANBioGRID, HPRD16246722 16916636 details
RPB1_HUMANCPSF1_HUMANBioGRID, HPRD9002523 9311784 details
RPB1_HUMANCPSF2_HUMANBioGRID, HPRD9002523 details
RPB1_HUMANCCNH_HUMANBioGRID14627702 15530371 9311822 details
RPB1_HUMANOTUD5_HUMANBioGRID30508113 details
RPB1_HUMANTCRG1_HUMANBioGRID, HPRD10908677 17218272 9315662 details
RPB1_HUMANACTB_HUMANBioGRID, HPRD10773068 15502823 15711563 18710935 435297 details
RPB1_HUMANANM5_HUMANBioGRID, DIP26700805 details
RPB1_HUMANTF2B_HUMANBioGRID, HPRD14963322 17643375 9159119 details
RPB1_HUMANPQBP1_HUMANBioGRID, HPRD12062018 details
RPB1_HUMANPRP19_HUMANBioGRID21536736 details
RPB1_HUMANPP1A_HUMANBioGRID12052871 details
RPB1_HUMANCACO1_HUMANBioGRID29187741 details
RPB1_HUMANSKP2_HUMANBioGRID30349055 details
RPB1_HUMANSUMO2_HUMANBioGRID32786267 details
RPB1_HUMANPPIG_HUMANHPRD9153302 details
RPB1_HUMANCAPAM_HUMANBioGRID, HPRD, IntAct12565871 26496610 details
RPB1_HUMANESR1_HUMANBioGRID, IntAct16957778 20308691 20348541 31527615 details
RPB1_HUMANKMT2A_HUMANBioGRID16199523 details
RPB1_HUMANRPB1_HUMANBioGRID15282296 details
RPB1_HUMANTDRD3_HUMANBioGRID, DIP, IntAct23066109 26700805 details
RPB1_HUMANRPB9_HUMANBioGRID19240132 22939629 24981860 26344197 details
RPB1_HUMANCPSF3_HUMANBioGRID, HPRD10454562 9002523 details
RPB1_HUMANSMUF1_HUMANBioGRID17996703 details
RPB1_HUMANRPB11_HUMANBioGRID15282305 19240132 24981860 26344197 details
RPB1_HUMANTCP4_HUMANBioGRID10024883 details
RPB1_HUMANU2AF2_HUMANBioGRID21536736 details
RPB1_HUMANMIER1_HUMANIntAct32814053 details
RPB1_HUMANIWS1_HUMANBioGRID19141475 details
RPB1_HUMANMEN1_HUMANBioGRID16199523 17050672 details
RPB1_HUMANXRCC5_HUMANBioGRID, HPRD12391174 details
RPB1_HUMANSPT6H_HUMANBioGRID17234882 19141475 24462114 details
RPB1_HUMANCCNT1_HUMANBioGRID12591939 details
RPB1_HUMANTHAP3_HUMANIntAct32814053 details
RPB1_HUMANNR0B2_HUMANBioGRID12198243 details
RPB1_HUMANPHF8_HUMANBioGRID20421419 details
RPB1_HUMANWAC_HUMANBioGRID21329877 details
RPB1_HUMANNSD1_HUMANBioGRID25193115 details
RPB1_HUMANCACO2_HUMANBioGRID29187741 details
RPB1_HUMANMDC1_HUMANBioGRID14578343 22990118 details
RPB1_HUMANCSTF2_HUMANBioGRID9002523 details
RPB1_HUMANCC14A_HUMANBioGRID22020438 details
RPB1_HUMANERG_HUMANBioGRID24591637 details
RPB1_HUMANUB2L3_HUMANBioGRID17996703 details
RPB1_HUMANCTDS2_HUMANBioGRID12721286 details
RPB1_HUMANP53_HUMANBioGRID21829606 details
RPB1_HUMANPTEN_HUMANBioGRID31685992 details
RPB1_HUMANERCC6_HUMANBioGRID, HPRD, IntAct10944529 16916636 20541997 26620705 32355176 9372911 details
RPB1_HUMANDDX5_HUMANBioGRID, UniProt12527917 17011493 29884807 details
RPB1_HUMANRPR1A_HUMANBioGRID, DIP, MINT24981860 24997600 details
RPB1_HUMANINT6_HUMANBioGRID20133760 details
RPB1_HUMANERPG3_HUMANBioGRID16916636 20541997 26620705 32355176 details
RPB1_HUMANNELFB_HUMANBioGRID11940650 details
RPB1_HUMANMAGAB_HUMANBioGRID31980388 details
RPB1_HUMANSETX_HUMANBioGRID, DIP26700805 details
RPB1_HUMANSMCA4_HUMANBioGRID11238380 15999204 16195385 8895581 9128241 9845365 details
RPB1_HUMANCBX3_HUMANBioGRID16061184 22684280 details
RPB1_HUMANGTF2I_HUMANBioGRID21880767 details
RPB1_HUMANSRC_HUMANBioGRID16957778 details
RPB1_HUMANCBP_HUMANBioGRID, HPRD30994454 9710619 details
RPB1_HUMANAIRE_HUMANBioGRID20085707 details
RPB1_HUMANTERA_HUMANBioGRID28036256 29180510 details
RPB1_HUMANE2F3_HUMANBioGRID20106982 details
RPB1_HUMANSYF1_HUMANBioGRID, HPRD, IntAct10944529 16916636 details
RPB1_HUMANCTR9_HUMANBioGRID, IntAct, UniProt16024656 26496610 26902284 details
RPB1_HUMANMED21_HUMANBioGRID, HPRD, IntAct24981860 28514442 9159119 9315662 9710619 details
RPB1_HUMANEP300_HUMANBioGRID16916636 9710619 details
RPB1_HUMANTAF10_HUMANBioGRID, HPRD15099517 details
RPB1_HUMANINT10_HUMANBioGRID16239144 details
RPB1_HUMANDDB1_HUMANBioGRID16916636 32355176 details
RPB1_HUMANFUS_HUMANBioGRID, HPRD12168660 29884807 details
RPB1_HUMANPCF11_HUMANBioGRID31980388 details
RPB1_HUMANSNF8_HUMANMINT19819239 details
RPB1_HUMANT2FB_HUMANBioGRID17643375 26344197 3860504 details
RPB1_HUMANZC3HD_HUMANBioGRID20133760 details
RPB1_HUMANERCC8_HUMANBioGRID16916636 32355176 details
RPB1_HUMANRFA1_HUMANBioGRID16916636 details
RPB1_HUMANUVSSA_HUMANBioGRID32355176 details
RPB1_HUMANABL1_HUMANHPRD7533294 details
RPB1_HUMANNONO_HUMANHPRD12358429 details
RPB1_HUMANRPR1B_HUMANBioGRID, DIP, IntAct, MINT22264791 24981860 24997600 26186194 28514442 details
RPB1_HUMANMED1_HUMANBioGRID, IntAct15989967 24981860 28514442 details
RPB1_HUMANMED28_HUMANBioGRID15175163 20133760 24981860 details
RPB1_HUMANHTSF1_HUMANBioGRID, HPRD10393184 10454543 details
RPB1_HUMANUBN1_HUMANBioGRID22195966 23602572 details
RPB1_HUMANSMC1A_HUMANBioGRID21880767 details
RPB1_HUMANCSN1_HUMANBioGRID16916636 details
RPB1_HUMANIRF3_HUMANBioGRID23994473 details
RPB1_HUMANRTRAF_HUMANUniProt16950395 details
RPB1_HUMANCDC73_HUMANBioGRID, DIP, UniProt15632063 15923622 16024656 26659056 details
RPB1_HUMANCUL5_HUMANBioGRID, IntAct21145461 30349055 details
RPB1_HUMANT2EB_HUMANBioGRID12665589 26344197 details
RPB1_HUMANCSH2_HUMANBioGRID, HPRD9312053 details
RPB1_HUMANPCNA_HUMANBioGRID21880767 32398829 32900933 details
RPB1_HUMANERCC3_HUMANBioGRID16916636 32355176 details
RPB1_HUMANMCE1_HUMANBioGRID27880917 29395067 details
RPB1_HUMANACL6A_HUMANHPRD9710619 details
RPB1_HUMANTRIP4_HUMANBioGRID20133760 27684187 details
RPB1_HUMANMYO6_HUMANBioGRID16949370 details
RPB1_HUMANZNHI2_HUMANBioGRID28561026 details
RPB1_HUMANPTK6_HUMANBioGRID23928995 details
RPB1_HUMANNCBP2_HUMANBioGRID29395067 details
RPB1_HUMANRTEL1_HUMANBioGRID32398829 details
RPB1_HUMANWWP2_HUMANBioGRID, IntAct28514442 31048545 details
RPB1_HUMANERCC2_HUMANBioGRID, DIP27193682 32355176 details
RPB1_HUMANRBP56_HUMANBioGRID8890175 details
RPB1_HUMANMCM7_HUMANBioGRID10454562 21880767 details
RPB1_HUMANNSMF_HUMANBioGRID10199401 details
RPB1_HUMANCUL7_HUMANBioGRID24711643 30349055 details
RPB1_HUMANHNRPF_HUMANHPRD10620016 details
RPB1_HUMANRENT1_HUMANHPRD6200476 details
RPB1_HUMANELP3_HUMANBioGRID11714725 details
RPB1_HUMANPIN1_HUMANBioGRID, HPRD10393805 10932246 details
RPB1_HUMANINT1_HUMANBioGRID20133760 details
RPB1_HUMANYAP1_HUMANBioGRID27684187 30472188 9305852 details
RPB1_HUMANSNF5_HUMANBioGRID11238380 8895581 9710619 details
RPB1_HUMANCDK2_HUMANBioGRID9311822 details
RPB1_HUMANRBX1_HUMANBioGRID30349055 32355176 details
RPB1_HUMANCCNK_HUMANBioGRID, DIP, HPRD, IntAct26659056 26748711 9632813 details
RPB1_HUMANMED30_HUMANBioGRID, MINT15989967 24981860 details
RPB1_HUMANNFKB1_HUMANBioGRID16319923 details
RPB1_HUMANMCM3_HUMANBioGRID, HPRD10454562 21880767 details
RPB1_HUMANCNOT1_HUMANBioGRID29802328 details
RPB1_HUMANDNLI3_HUMANBioGRID30994454 details
RPB1_HUMANSLX4_HUMANBioGRID32398829 details
RPB1_HUMANKLK2_HUMANHPRD15542435 details
RPB1_HUMANCCNL2_HUMANBioGRID, HPRD14684736 details
RPB1_HUMANSET1B_HUMANBioGRID17998332 details
RPB1_HUMANERCC1_HUMANBioGRID16916636 details
RPB1_HUMANT2AG_HUMANBioGRID10454562 details
RPB1_HUMANMBD2_HUMANBioGRID12665568 details
RPB1_HUMANFACD2_HUMANBioGRID31180492 32398829 details
RPB1_HUMANTRAK1_HUMANHPRD12435728 details
RPB1_HUMANELP1_HUMANIntAct11714725 details
RPB1_HUMANAGO1_HUMANBioGRID16936726 24086155 details
RPB1_HUMANINT11_HUMANBioGRID16239144 details
RPB1_HUMANDHX9_HUMANBioGRID, HPRD11149922 12665568 19309309 26902284 29884807 details
RPB1_HUMANTHOC4_HUMANBioGRID24462114 details
RPB1_HUMANSCAI_HUMANBioGRID28700933 details
RPB1_HUMANPHRF1_HUMANBioGRID32460013 32730336 details
RPB1_HUMANSMCA2_HUMANBioGRID11238380 16341228 8895581 9710619 details
RPB1_HUMANMCAF1_HUMANBioGRID19106100 details
RPB1_HUMANAFF1_HUMANBioGRID21030982 details
RPB1_HUMANHIRA_HUMANBioGRID22195966 23602572 details
RPB1_HUMANMCM2_HUMANBioGRID10454562 details
RPB1_HUMANBRCA2_HUMANBioGRID29386125 details
RPB1_HUMANPNKP_HUMANBioGRID30994454 details
RPB1_HUMANHAP1_HUMANBioGRID30994454 details
RPB1_HUMANDDX17_HUMANBioGRID29884807 details
RPB1_HUMANSET1A_HUMANBioGRID17998332 details
RPB1_HUMANCABIN_HUMANBioGRID22195966 details
RPB1_HUMANHMGN1_HUMANBioGRID16916636 details
RPB1_HUMANCDN1C_HUMANBioGRID20106982 details
RPB1_HUMANCUL1_HUMANBioGRID30349055 details
RPB1_HUMANMAGI2_HUMANIntAct17353931 details
RPB1_HUMANDICER_HUMANDIP24814348 details
RPB1_HUMANEGLN1_HUMANBioGRID18285459 details
RPB1_HUMANRXRA_HUMANBioGRID15863722 details
RPB1_HUMANQKI_HUMANBioGRID20133760 details
RPB1_HUMANWDR82_HUMANBioGRID20516061 details
RPB1_HUMANSRBP1_HUMANBioGRID29033323 details
RPB1_HUMANCPSF5_HUMANBioGRID31980388 details
RPB1_HUMANCUL2_HUMANBioGRID, IntAct21145461 30349055 details
RPB1_HUMANCDK12_HUMANDIP, HPRD11683387 26659056 details
RPB1_HUMANATX3_HUMANBioGRID30994454 details
RPB1_HUMANHNRPK_HUMANDIP32499643 details
RPB1_HUMANNELFE_HUMANBioGRID12612062 details
RPB1_HUMANINT5_HUMANBioGRID20133760 details
RPB1_HUMANRAD52_HUMANBioGRID12372413 details
RPB1_HUMANTAF4_HUMANBioGRID30994454 details
RPB1_HUMANCASPA_HUMANHPRD9153302 details
RPB1_HUMANTRAM2_HUMANHPRD14612417 details
RPB1_HUMANTF65_HUMANBioGRID23994473 details
RPB1_HUMANH2B2E_HUMANBioGRID24837678 details
RPB1_HUMANAGO2_HUMANBioGRID26902284 details
RPB1_HUMANCUL3_HUMANBioGRID30349055 details
RPB1_HUMANBAZ1B_HUMANBioGRID31045206 details
RPB1_HUMANINT3_HUMANBioGRID20133760 details
RPB1_HUMANPSB9_HUMANBioGRID16957778 details
RPB1_HUMANENL_HUMANBioGRID21873227 details
RPB1_HUMANEWS_HUMANBioGRID20972445 details
RPB1_HUMANNS1BP_HUMANBioGRID23825951 details
RPB1_HUMANUSPL1_HUMANBioGRID24413172 details
RPB1_HUMANHD_HUMANBioGRID30994454 details
RPB1_HUMANSMYD3_HUMANBioGRID15235609 details
RPB1_HUMANNF1_HUMANBioGRID15999204 details
RPB1_HUMANH2AX_HUMANBioGRID15613478 31045206 details
RPB1_HUMANSMC3_HUMANBioGRID21880767 details
RPB1_HUMANELL_HUMANHPRD9268387 details
RPB1_HUMANEGLN2_HUMANBioGRID18285459 details
RPB1_HUMANSTN1_HUMANBioGRID20133760 details
RPB1_HUMANXPF_HUMANBioGRID16916636 details
RPB1_HUMANXPA_HUMANBioGRID16916636 details