Entity Details

Primary name PSB8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP28062
EntryNamePSB8_HUMAN
FullNameProteasome subunit beta type-8
TaxID9606
Evidenceevidence at protein level
Length276
SequenceStatuscomplete
DateCreated1992-08-01
DateModified2021-06-02

Ontological Relatives

GenesPSMB8

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000209 protein polyubiquitination
GO:0000502 proteasome complex
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0004175 endopeptidase activity
GO:0004298 threonine-type endopeptidase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005839 proteasome core complex
GO:0006521 regulation of cellular amino acid metabolic process
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0016032 viral process
GO:0016579 protein deubiquitination
GO:0019774 proteasome core complex, beta-subunit complex
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0036388 pre-replicative complex assembly
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043488 regulation of mRNA stability
GO:0043687 post-translational protein modification
GO:0045444 fat cell differentiation
GO:0050852 T cell receptor signaling pathway
GO:0052548 regulation of endopeptidase activity
GO:0055085 transmembrane transport
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060337 type I interferon signaling pathway
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070062 extracellular exosome
GO:0070498 interleukin-1-mediated signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1902036 regulation of hematopoietic stem cell differentiation
GO:1990111 spermatoproteasome complex

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000243 Peptidase T1A, proteasome beta-subunitFamilyFamily
IPR001353 Proteasome, subunit alpha/betaFamilyFamily
IPR016050 Proteasome beta-type subunit, conserved siteSiteConserved site
IPR023333 Proteasome B-type subunitFamilyFamily
IPR029055 Nucleophile aminohydrolases, N-terminalFamilyHomologous superfamily
IPR035705 Proteasome subunit beta type 8FamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB08889 CarfilzomibDrugbanksmall molecule

Interactions

46 interactions

InteractorPartnerSourcesPublicationsLink
PSB8_HUMANLSM1_HUMANBioGRID, HPRD, IntAct15231747 32296183 details
PSB8_HUMANTAP1_HUMANBioGRID, HPRD, IntAct15488952 details
PSB8_HUMANTAP2_HUMANBioGRID, HPRD, IntAct15488952 details
PSB8_HUMANPSB7_HUMANBioGRID, IntAct16423992 17948026 20723761 22863883 22939629 26344197 details
PSB8_HUMANGNA1_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANREL_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANPCH2_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANTRAF3_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANUBAP2_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANIKBD_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANRPB7_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANZMY12_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANDUS23_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANSNX5_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANYJEN3_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANPFD5_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANWWOX_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANTET5B_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANINCA1_HUMANBioGRID, IntAct32296183 details
PSB8_HUMANGRN_HUMANIntAct32814053 details
PSB8_HUMANHSPB1_HUMANIntAct32814053 details
PSB8_HUMANWFS1_HUMANIntAct32814053 details
PSB8_HUMANKIF1B_HUMANIntAct32814053 details
PSB8_HUMANRNF11_HUMANIntAct32814053 details
PSB8_HUMANSODC_HUMANIntAct32814053 details
PSB8_HUMANA4_HUMANIntAct32814053 details
PSB8_HUMANHD_HUMANIntAct32814053 details
PSB8_HUMANATX1_HUMANIntAct32814053 details
PSB8_HUMANTADBP_HUMANIntAct32814053 details
PSB8_HUMANPSB1_HUMANBioGRID17506986 17948026 22863883 22939629 26344197 details
PSB8_HUMANPSB9_HUMANBioGRID17506986 17948026 details
PSB8_HUMANPOMP_HUMANBioGRID15944226 17948026 details
PSB8_HUMANMDR1_HUMANBioGRID15488952 details
PSB8_HUMANPSB4_HUMANBioGRID17948026 22863883 22939629 26344197 details
PSB8_HUMANPSB3_HUMANBioGRID17948026 22939629 26344197 details
PSB8_HUMANPSB6_HUMANBioGRID11745344 17948026 22863883 22939629 26344197 details
PSB8_HUMANPSB8_HUMANBioGRID, HPRD1429565 17948026 details
PSB8_HUMANPSB10_HUMANBioGRID17948026 details
PSB8_HUMANPSA6_HUMANBioGRID17948026 22863883 22939629 26344197 details
PSB8_HUMANMEOX2_HUMANBioGRID32296183 details
PSB8_HUMANPSA2_HUMANBioGRID, IntAct15887188 19193609 20937868 22863883 22939629 26344197 31114588 details
PSB8_HUMANPSA1_HUMANBioGRID, IntAct22863883 22939629 26344197 29568061 8206875 details
PSB8_HUMANPSA4_HUMANBioGRID15303969 22863883 22939629 26344197 9311996 details
PSB8_HUMANUBP7_HUMANBioGRID19193609 details
PSB8_HUMANPSME1_HUMANBioGRID11745344 details
PSB8_HUMANPSME2_HUMANBioGRID11745344 details