Entity Details

Primary name NDUS1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP28331
EntryNameNDUS1_HUMAN
FullNameNADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length727
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesNDUFS1

GO terms

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GOName
GO:0005739 mitochondrion
GO:0005747 mitochondrial respiratory chain complex I
GO:0005758 mitochondrial intermembrane space
GO:0005759 mitochondrial matrix
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0008637 apoptotic mitochondrial changes
GO:0009055 electron transfer activity
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0045333 cellular respiration
GO:0046034 ATP metabolic process
GO:0046872 metal ion binding
GO:0051537 2 iron, 2 sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0051881 regulation of mitochondrial membrane potential
GO:0072593 reactive oxygen species metabolic process

Subcellular Location

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Subcellular Location
Mitochondrion inner membrane

Domains

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DomainNameCategoryType
IPR000283 NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved siteSiteConserved site
IPR001041 2Fe-2S ferredoxin-type iron-sulfur binding domainDomainDomain
IPR006656 Molybdopterin oxidoreductaseDomainDomain
IPR006963 Molybdopterin oxidoreductase, 4Fe-4S domainDomainDomain
IPR010228 NADH:ubiquinone oxidoreductase, subunit GFamilyFamily
IPR015405 NADH-quinone oxidoreductase, chain G, C-terminalDomainDomain
IPR019574 NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur bindingDomainDomain
IPR036010 2Fe-2S ferredoxin-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule

Interactions

39 interactions

InteractorPartnerSourcesPublicationsLink
NDUS1_HUMANC1T9A_HUMANBioGRID, IntAct23414517 details
NDUS1_HUMANECE2_HUMANMINT23455924 details
NDUS1_HUMANEFMT4_HUMANMINT23455924 details
NDUS1_HUMANEFCE2_HUMANMINT23455924 details
NDUS1_HUMANHD_HUMANIntAct17500595 32814053 details
NDUS1_HUMANMET27_HUMANIntAct32814053 details
NDUS1_HUMANBOD1_HUMANIntAct32814053 details
NDUS1_HUMANTHAP3_HUMANIntAct32814053 details
NDUS1_HUMANCOG8_HUMANIntAct32814053 details
NDUS1_HUMANBRME1_HUMANIntAct32814053 details
NDUS1_HUMANLRC61_HUMANIntAct32814053 details
NDUS1_HUMANDPYL5_HUMANIntAct32814053 details
NDUS1_HUMANF135B_HUMANIntAct32814053 details
NDUS1_HUMANLAR4B_HUMANIntAct32814053 details
NDUS1_HUMANHAUS7_HUMANIntAct32814053 details
NDUS1_HUMANDELE1_HUMANIntAct32814053 details
NDUS1_HUMANK0408_HUMANIntAct32814053 details
NDUS1_HUMANPIMT_HUMANIntAct32814053 details
NDUS1_HUMANNDF1_HUMANIntAct32814053 details
NDUS1_HUMANCX7A1_HUMANIntAct32814053 details
NDUS1_HUMANKLF5_HUMANIntAct32814053 details
NDUS1_HUMANWFS1_HUMANBioGRID, IntAct31536960 32814053 details
NDUS1_HUMANKIF1B_HUMANIntAct32814053 details
NDUS1_HUMANCASP3_HUMANBioGRID15186778 details
NDUS1_HUMANKDM1A_HUMANBioGRID23455924 details
NDUS1_HUMANMDM2_HUMANBioGRID30879903 details
NDUS1_HUMANHLAB_HUMANIntAct17353931 details
NDUS1_HUMANNDUA9_HUMANBioGRID, IntAct, MINT22939629 24344204 26344197 27173435 31536960 unassigned1312 details
NDUS1_HUMANSTOM_HUMANBioGRID, IntAct27173435 unassigned1312 details
NDUS1_HUMANPIGS_HUMANBioGRID, IntAct27173435 unassigned1312 details
NDUS1_HUMANGPAA1_HUMANBioGRID, IntAct27173435 unassigned1312 details
NDUS1_HUMANGDIA_HUMANBioGRID, IntAct27173435 unassigned1312 details
NDUS1_HUMANSOAT1_HUMANBioGRID, IntAct27173435 29128334 unassigned1312 details
NDUS1_HUMANACAP2_HUMANBioGRID, IntAct27173435 unassigned1312 details
NDUS1_HUMANEHBP1_HUMANBioGRID, IntAct27173435 unassigned1312 details
NDUS1_HUMANMBOA7_HUMANBioGRID, IntAct27173435 unassigned1312 details
NDUS1_HUMANTNIK_HUMANIntAct31413325 details
NDUS1_HUMANOSMR_HUMANMINT32807793 details
NDUS1_HUMANMDHM_HUMANBioGRID, HPRD32877691 6439716 details