Entity Details

Primary name 5HT2C_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP28335
EntryName5HT2C_HUMAN
FullName5-hydroxytryptamine receptor 2C
TaxID9606
Evidenceevidence at protein level
Length458
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesHTR2C

GO terms

Show/Hide Table
GOName
GO:0001587 Gq/11-coupled serotonin receptor activity
GO:0001662 behavioral fear response
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006874 cellular calcium ion homeostasis
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007208 phospholipase C-activating serotonin receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007626 locomotory behavior
GO:0007631 feeding behavior
GO:0010513 positive regulation of phosphatidylinositol biosynthetic process
GO:0019934 cGMP-mediated signaling
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0031644 regulation of nervous system process
GO:0032098 regulation of appetite
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043397 regulation of corticotropin-releasing hormone secretion
GO:0045202 synapse
GO:0045600 positive regulation of fat cell differentiation
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051378 serotonin binding
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071886 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding
GO:0098664 G protein-coupled serotonin receptor signaling pathway
GO:0098666 G protein-coupled serotonin receptor complex

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000377 5-Hydroxytryptamine 2C receptorFamilyFamily
IPR002231 5-hydroxytryptamine receptor familyFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00193 TramadolDrugbanksmall molecule
DB00246 ZiprasidoneDrugbanksmall molecule
DB00247 MethysergideDrugbanksmall molecule
DB00248 CabergolineDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00370 MirtazapineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00420 PromazineDrugbanksmall molecule
DB00434 CyproheptadineDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00472 FluoxetineDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00502 HaloperidolDrugbanksmall molecule
DB00540 NortriptylineDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00574 FenfluramineDrugbanksmall molecule
DB00589 LisurideDrugbanksmall molecule
DB00623 FluphenazineDrugbanksmall molecule
DB00656 TrazodoneDrugbanksmall molecule
DB00696 ErgotamineDrugbanksmall molecule
DB00714 ApomorphineDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00726 TrimipramineDrugbanksmall molecule
DB00734 RisperidoneDrugbanksmall molecule
DB00777 PropiomazineDrugbanksmall molecule
DB00805 MinaprineDrugbanksmall molecule
DB00924 CyclobenzaprineDrugbanksmall molecule
DB00934 MaprotilineDrugbanksmall molecule
DB01049 Ergoloid mesylateDrugbanksmall molecule
DB01079 TegaserodDrugbanksmall molecule
DB01142 DoxepinDrugbanksmall molecule
DB01149 NefazodoneDrugbanksmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB01175 EscitalopramDrugbanksmall molecule
DB01186 PergolideDrugbanksmall molecule
DB01191 DexfenfluramineDrugbanksmall molecule
DB01200 BromocriptineDrugbanksmall molecule
DB01221 KetamineDrugbanksmall molecule
DB01224 QuetiapineDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01239 ChlorprothixeneDrugbanksmall molecule
DB01242 ClomipramineDrugbanksmall molecule
DB01267 PaliperidoneDrugbanksmall molecule
DB01392 YohimbineDrugbanksmall molecule
DB01403 MethotrimeprazineDrugbanksmall molecule
DB01454 MidomafetamineDrugbanksmall molecule
DB01537 4-Bromo-2,5-dimethoxyphenethylamineDrugbanksmall molecule
DB04871 LorcaserinDrugbanksmall molecule
DB04884 DapoxetineDrugbanksmall molecule
DB04948 LofexidineDrugbanksmall molecule
DB05492 Epicept NP-1Drugbanksmall molecule
DB06144 SertindoleDrugbanksmall molecule
DB06148 MianserinDrugbanksmall molecule
DB06153 PizotifenDrugbanksmall molecule
DB06216 AsenapineDrugbanksmall molecule
DB06229 OcaperidoneDrugbanksmall molecule
DB06446 DotarizineDrugbanksmall molecule
DB06512 DeramciclaneDrugbanksmall molecule
DB06594 AgomelatineDrugbanksmall molecule
DB06678 EsmirtazapineDrugbanksmall molecule
DB09014 CaptodiameDrugbanksmall molecule
DB09194 EtoperidoneDrugbanksmall molecule
DB09195 LorpiprazoleDrugbanksmall molecule
DB09304 SetiptilineDrugbanksmall molecule
DB11273 DihydroergocornineDrugbanksmall molecule
DB12110 m-ChlorophenylpiperazineDrugbanksmall molecule
DB12141 GilteritinibDrugbanksmall molecule
DB12163 SarpogrelateDrugbanksmall molecule
DB12177 EplivanserinDrugbanksmall molecule
DB13025 TiaprideDrugbanksmall molecule
DB13345 DihydroergocristineDrugbanksmall molecule
DB13940 2,5-Dimethoxy-4-ethylthioamphetamineDrugbanksmall molecule
DB14185 Aripiprazole lauroxilDrugbanksmall molecule

Interactions

46 interactions

InteractorPartnerSourcesPublicationsLink
5HT2C_HUMANMPDZ_HUMANBioGRID, HPRD, MINT11150294 12682077 9537516 details
5HT2C_HUMANS39A9_HUMANBioGRID, IntAct32296183 details
5HT2C_HUMANEMP1_HUMANBioGRID, IntAct32296183 details
5HT2C_HUMANTM147_HUMANBioGRID, IntAct28514442 32296183 details
5HT2C_HUMANBI1_HUMANBioGRID, IntAct32296183 details
5HT2C_HUMANCNIH1_HUMANBioGRID, IntAct32296183 details
5HT2C_HUMANS39A1_HUMANBioGRID, IntAct, MINT28298427 28514442 details
5HT2C_HUMANRTN4_HUMANBioGRID, IntAct, MINT28298427 28514442 details
5HT2C_HUMANAT2B3_HUMANBioGRID, MINT28298427 details
5HT2C_HUMANCXA1_HUMANBioGRID, MINT28298427 details
5HT2C_HUMANSGCB_HUMANBioGRID, MINT28298427 details
5HT2C_HUMANCREL1_HUMANBioGRID, MINT28298427 details
5HT2C_HUMANGHITM_HUMANBioGRID, MINT28298427 details
5HT2C_HUMANVATL_HUMANBioGRID, MINT28298427 details
5HT2C_HUMANCD003_HUMANBioGRID, MINT28298427 details
5HT2C_HUMANMF14A_HUMANBioGRID, MINT28298427 details
5HT2C_HUMANERG28_HUMANBioGRID, MINT28298427 details
5HT2C_HUMANTMM94_HUMANBioGRID, MINT28298427 details
5HT2C_HUMANRENR_HUMANBioGRID, MINT28298427 details
5HT2C_HUMANGPR37_HUMANBioGRID, MINT28298427 details
5HT2C_HUMANS29A1_HUMANBioGRID, MINT28298427 details
5HT2C_HUMANGPC5B_HUMANBioGRID, MINT28298427 details
5HT2C_HUMANMYPR_HUMANBioGRID, MINT28298427 details
5HT2C_HUMANTM9S2_HUMANBioGRID, MINT28298427 details
5HT2C_HUMANSPNS1_HUMANBioGRID, MINT28298427 details
5HT2C_HUMANTPIS_HUMANBioGRID, MINT28298427 details
5HT2C_HUMANCBX3_HUMANBioGRID, MINT28298427 details
5HT2C_HUMANLIN7C_HUMANBioGRID, HPRD, MINT12006486 28298427 details
5HT2C_HUMANSCRIB_HUMANIntAct30126976 details
5HT2C_HUMANDLG1_HUMANIntAct30126976 details
5HT2C_HUMAN5HT2A_HUMANIntAct28258217 30157263 details
5HT2C_HUMANADRB2_HUMANIntAct15518545 30157263 details
5HT2C_HUMAN5HT2C_HUMANHPRD, IntAct15518545 16195233 25770211 28258217 details
5HT2C_HUMAN5HT2B_HUMANIntAct28258217 details
5HT2C_HUMANMTR1A_HUMANIntAct25770211 details
5HT2C_HUMANMTR1B_HUMANIntAct25770211 details
5HT2C_HUMANACM4_HUMANIntAct15518545 details
5HT2C_HUMANGHSR_HUMANIntAct25727097 details
5HT2C_HUMANDLG4_HUMANBioGRID, HPRD12006486 details
5HT2C_HUMANAPBA1_HUMANBioGRID, HPRD12006486 details
5HT2C_HUMANCALM1_HUMANBioGRID, HPRD18768750 details
5HT2C_HUMANCALM2_HUMANBioGRID, HPRD18768750 details
5HT2C_HUMANCALM3_HUMANBioGRID, HPRD18768750 details
5HT2C_HUMANSNTA1_HUMANBioGRID15123239 details
5HT2C_HUMANGNAQ_HUMANHPRD11916537 details
5HT2C_HUMANARRB2_HUMANHPRD18768750 details