Entity Details

Primary name ERCC5_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP28715
EntryNameERCC5_HUMAN
FullNameDNA excision repair protein ERCC-5
TaxID9606
Evidenceevidence at protein level
Length1186
SequenceStatuscomplete
DateCreated1993-04-01
DateModified2021-06-02

Ontological Relatives

GenesERCC5

GO terms

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GOName
GO:0000109 nucleotide-excision repair complex
GO:0000405 bubble DNA binding
GO:0000724 double-strand break repair via homologous recombination
GO:0000993 RNA polymerase II complex binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0004519 endonuclease activity
GO:0004520 endodeoxyribonuclease activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006285 base-excision repair, AP site formation
GO:0006289 nucleotide-excision repair
GO:0006293 nucleotide-excision repair, preincision complex stabilization
GO:0006294 nucleotide-excision repair, preincision complex assembly
GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0008047 enzyme activator activity
GO:0009411 response to UV
GO:0009650 UV protection
GO:0010225 response to UV-C
GO:0032991 protein-containing complex
GO:0033683 nucleotide-excision repair, DNA incision
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0044877 protein-containing complex binding
GO:0046872 metal ion binding
GO:0047485 protein N-terminus binding
GO:0050790 regulation of catalytic activity

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR001044 XPG/Rad2 endonuclease, eukaryotesFamilyFamily
IPR006084 XPG/Rad2 endonucleaseFamilyFamily
IPR006085 XPG, N-terminalDomainDomain
IPR006086 XPG-I domainDomainDomain
IPR008918 Helix-hairpin-helix motif, class 2SiteConserved site
IPR019974 XPG conserved siteSiteConserved site
IPR029060 PIN-like domain superfamilyFamilyHomologous superfamily
IPR036279 5'-3' exonuclease, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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