Entity Details

Primary name AA2AR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29274
EntryNameAA2AR_HUMAN
FullNameAdenosine receptor A2a
TaxID9606
Evidenceevidence at protein level
Length412
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesADORA2A

GO terms

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GOName
GO:0001609 G protein-coupled adenosine receptor activity
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0005882 intermediate filament
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006355 regulation of transcription, DNA-templated
GO:0006469 negative regulation of protein kinase activity
GO:0006909 phagocytosis
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006968 cellular defense response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007205 protein kinase C-activating G protein-coupled receptor signaling pathway
GO:0007267 cell-cell signaling
GO:0007271 synaptic transmission, cholinergic
GO:0007417 central nervous system development
GO:0007596 blood coagulation
GO:0007600 sensory perception
GO:0007626 locomotory behavior
GO:0008015 blood circulation
GO:0008285 negative regulation of cell population proliferation
GO:0012505 endomembrane system
GO:0014049 positive regulation of glutamate secretion
GO:0014057 positive regulation of acetylcholine secretion, neurotransmission
GO:0014061 regulation of norepinephrine secretion
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0019899 enzyme binding
GO:0030425 dendrite
GO:0030673 axolemma
GO:0031000 response to caffeine
GO:0031802 type 5 metabotropic glutamate receptor binding
GO:0035249 synaptic transmission, glutamatergic
GO:0035810 positive regulation of urine volume
GO:0035815 positive regulation of renal sodium excretion
GO:0040013 negative regulation of locomotion
GO:0042311 vasodilation
GO:0042493 response to drug
GO:0042755 eating behavior
GO:0042802 identical protein binding
GO:0043025 neuronal cell body
GO:0043116 negative regulation of vascular permeability
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0044267 cellular protein metabolic process
GO:0044877 protein-containing complex binding
GO:0045938 positive regulation of circadian sleep/wake cycle, sleep
GO:0048143 astrocyte activation
GO:0048786 presynaptic active zone
GO:0048812 neuron projection morphogenesis
GO:0050714 positive regulation of protein secretion
GO:0051393 alpha-actinin binding
GO:0051881 regulation of mitochondrial membrane potential
GO:0051899 membrane depolarization
GO:0051924 regulation of calcium ion transport
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060079 excitatory postsynaptic potential
GO:0060134 prepulse inhibition
GO:0098978 glutamatergic synapse
GO:0099055 integral component of postsynaptic membrane
GO:0099056 integral component of presynaptic membrane
GO:1900273 positive regulation of long-term synaptic potentiation
GO:2000300 regulation of synaptic vesicle exocytosis

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR001513 Adenosine A2A receptorFamilyFamily
IPR001634 Adenosine receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00201 CaffeineDrugbanksmall molecule
DB00277 TheophyllineDrugbanksmall molecule
DB00358 MefloquineDrugbanksmall molecule
DB00555 LamotrigineDrugbanksmall molecule
DB00640 AdenosineDrugbanksmall molecule
DB00651 DyphyllineDrugbanksmall molecule
DB00806 PentoxifyllineDrugbanksmall molecule
DB00824 EnprofyllineDrugbanksmall molecule
DB01303 OxtriphyllineDrugbanksmall molecule
DB01412 TheobromineDrugbanksmall molecule
DB04853 BinodenosonDrugbanksmall molecule
DB04932 DefibrotideDrugbankbiotech
DB05009 ApadenosonDrugbanksmall molecule
DB05191 Atl146eDrugbanksmall molecule
DB06213 RegadenosonDrugbanksmall molecule
DB08770 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenolDrugbanksmall molecule
DB09273 DoxofyllineDrugbanksmall molecule
DB11757 IstradefyllineDrugbanksmall molecule
DB14132 8-chlorotheophyllineDrugbanksmall molecule

Interactions

31 interactions

InteractorPartnerSourcesPublicationsLink
AA2AR_HUMANNAMPT_HUMANBioGRID, MINT18486613 details
AA2AR_HUMANAA2AR_HUMANBioGRID, HPRD, IntAct, MINT12804599 12837758 18675812 19013155 29568380 details
AA2AR_HUMANCYH2_HUMANBioGRID, HPRD, IntAct16027149 details
AA2AR_HUMANAA1R_HUMANIntAct16481441 details
AA2AR_HUMANNECA2_HUMANBioGRID, IntAct, UniProt17689978 19694902 details
AA2AR_HUMANCNR1_HUMANBioGRID, I2D, IntAct17356572 23296780 28102227 details
AA2AR_HUMANUBP4_HUMANI2D16339847 details
AA2AR_HUMANCALM2_HUMANI2D19632986 details
AA2AR_HUMANDRD2_HUMANBioGRID, HPRD, I2D, IntAct12804599 19632986 23296780 29568380 details
AA2AR_HUMANSNG1_HUMANBioGRID, IntAct32296183 details
AA2AR_HUMANBET1_HUMANBioGRID, IntAct32296183 details
AA2AR_HUMANGPR37_HUMANBioGRID, MINT28298427 details
AA2AR_HUMANCHIN_HUMANBioGRID, MINT28298427 details
AA2AR_HUMANHNRH3_HUMANBioGRID, MINT28298427 details
AA2AR_HUMANPOZP3_HUMANBioGRID, MINT28298427 details
AA2AR_HUMANPPM1J_HUMANBioGRID, MINT28298427 details
AA2AR_HUMANODPB_HUMANBioGRID, MINT28298427 details
AA2AR_HUMANRHBD2_HUMANBioGRID, MINT28298427 details
AA2AR_HUMANS2539_HUMANBioGRID, MINT28298427 details
AA2AR_HUMANNADAP_HUMANBioGRID, MINT28298427 details
AA2AR_HUMANSPNS1_HUMANBioGRID, MINT28298427 details
AA2AR_HUMANAA2BR_HUMANIntAct29568380 details
AA2AR_HUMANHRH3_HUMANBioGRID29217157 details
AA2AR_HUMANCD4_HUMANBioGRID17356572 details
AA2AR_HUMANACTN4_HUMANHPRD12837758 details
AA2AR_HUMANACTN1_HUMANHPRD12837758 details
AA2AR_HUMANACTN3_HUMANHPRD12837758 details
AA2AR_HUMANWLS_HUMANUniProt28734904 31286866 details
AA2AR_HUMANADA_HUMANBioGRID, HPRD11125033 details
AA2AR_HUMANGRM5_HUMANBioGRID12189203 details
AA2AR_HUMANACTN2_HUMANHPRD12837758 details