Entity Details

Primary name EPHA8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP29322
EntryNameEPHA8_HUMAN
FullNameEphrin type-A receptor 8
TaxID9606
Evidenceevidence at protein level
Length1005
SequenceStatuscomplete
DateCreated1992-12-01
DateModified2021-06-02

Ontological Relatives

GenesEPHA8

GO terms

Show/Hide Table
GOName
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005004 GPI-linked ephrin receptor activity
GO:0005005 transmembrane-ephrin receptor activity
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006929 substrate-dependent cell migration
GO:0007155 cell adhesion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007411 axon guidance
GO:0016322 neuron remodeling
GO:0019838 growth factor binding
GO:0030155 regulation of cell adhesion
GO:0031175 neuron projection development
GO:0031901 early endosome membrane
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0033674 positive regulation of kinase activity
GO:0043005 neuron projection
GO:0043235 receptor complex
GO:0043410 positive regulation of MAPK cascade
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0046777 protein autophosphorylation
GO:0048013 ephrin receptor signaling pathway
GO:0071372 cellular response to follicle-stimulating hormone stimulus

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Cell projection
Early endosome membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001090 Ephrin receptor ligand binding domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001426 Tyrosine-protein kinase, receptor class V, conserved siteSiteConserved site
IPR001660 Sterile alpha motif domainDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR008979 Galactose-binding-like domain superfamilyFamilyHomologous superfamily
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR016257 Ephrin receptor type-A /type-BFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR020691 Ephrin type-A receptor 8FamilyFamily
IPR027936 Ephrin receptor, transmembrane domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule