Entity Details

Primary name RFC4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35249
EntryNameRFC4_HUMAN
FullNameReplication factor C subunit 4
TaxID9606
Evidenceevidence at protein level
Length363
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesRFC4

GO terms

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GOName
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005663 DNA replication factor C complex
GO:0006260 DNA replication
GO:0006261 DNA-dependent DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006281 DNA repair
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006297 nucleotide-excision repair, DNA gap filling
GO:0016887 ATP hydrolysis activity
GO:0019985 translesion synthesis
GO:0031390 Ctf18 RFC-like complex
GO:0031391 Elg1 RFC-like complex
GO:0032201 telomere maintenance via semi-conservative replication
GO:0032508 DNA duplex unwinding
GO:0033683 nucleotide-excision repair, DNA incision
GO:0042276 error-prone translesion synthesis
GO:0042769 DNA damage response, detection of DNA damage
GO:0070987 error-free translesion synthesis
GO:1900264 positive regulation of DNA-directed DNA polymerase activity
GO:1901796 regulation of signal transduction by p53 class mediator

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR003593 AAA+ ATPase domainDomainDomain
IPR003959 ATPase, AAA-type, coreDomainDomain
IPR008921 DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminalFamilyHomologous superfamily
IPR013748 Replication factor C, C-terminalDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily

Diseases

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Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
RFC4_HUMANRFC2_HUMANBioGRID, HPRD, IntAct, UniProt15655353 16582606 22939629 24981860 26344197 28514442 8692848 9092549 9228079 9488738 9751713 details
RFC4_HUMANRFC5_HUMANBioGRID, HPRD, IntAct16189514 22939629 24981860 25416956 26264872 26344197 28514442 29892012 30021884 31515488 32296183 8692848 9092549 9228079 9488738 9751713 details
RFC4_HUMANRFC1_HUMANBioGRID, IntAct18245774 22939629 26344197 28514442 9092549 9488738 details
RFC4_HUMANRFC3_HUMANBioGRID, HPRD, IntAct22939629 26344197 28514442 32296183 8692848 9092549 9488738 details
RFC4_HUMANRNF41_HUMANBioGRID, IntAct, MINT21516116 25416956 27803151 32296183 details
RFC4_HUMANPCNA_HUMANBioGRID, HPRD, IntAct10051561 12171929 22939629 24958773 26496610 9228079 details
RFC4_HUMANCTF18_HUMANBioGRID, HPRD, IntAct11486023 12930902 28514442 details
RFC4_HUMANRAD17_HUMANBioGRID, DIP, HPRD, IntAct11907025 14605214 14624239 28514442 details
RFC4_HUMANBRD4_HUMANBioGRID, HPRD, MINT12192049 24981860 31753913 32416067 details
RFC4_HUMANTIF1B_HUMANBioGRID29955894 details
RFC4_HUMANPTEN_HUMANBioGRID31685992 32249768 details
RFC4_HUMANSUMO2_HUMANBioGRID32786267 details
RFC4_HUMANMYC_HUMANBioGRID, IntAct17353931 21150319 29467282 30415952 details
RFC4_HUMAN1433Z_HUMANMINT15161933 details
RFC4_HUMANNEUL4_HUMANBioGRID, IntAct27173435 unassigned1312 details
RFC4_HUMANFBSP1_HUMANBioGRID, IntAct27173435 unassigned1312 details
RFC4_HUMANATAD5_HUMANBioGRID, IntAct20147293 24981860 28514442 31160570 details
RFC4_HUMANPMS1_HUMANBioGRID17148452 details
RFC4_HUMANPML_HUMANBioGRID18212063 details
RFC4_HUMANRARA_HUMANBioGRID18212063 details
RFC4_HUMANFAN1_HUMANBioGRID20603015 details
RFC4_HUMANPIDD1_HUMANBioGRID21415862 details
RFC4_HUMANSMRCD_HUMANBioGRID21549307 details
RFC4_HUMANPRAME_HUMANBioGRID22912744 details
RFC4_HUMAN3MG_HUMANBioGRID23537643 details
RFC4_HUMANRFA1_HUMANBioGRID24332808 26474068 details
RFC4_HUMANABCE1_HUMANBioGRID25659154 details
RFC4_HUMANMCM9_HUMANBioGRID26300262 26870752 details
RFC4_HUMANGRWD1_HUMANBioGRID29991511 details
RFC4_HUMANTRI29_HUMANBioGRID26095369 details
RFC4_HUMANCDK4_HUMANHPRD10353443 details
RFC4_HUMANHDAC1_HUMANHPRD12045192 details