Entity Details

Primary name HRH1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP35367
EntryNameHRH1_HUMAN
FullNameHistamine H1 receptor
TaxID9606
Evidenceevidence at protein level
Length487
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesHRH1

GO terms

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GOName
GO:0004930 G protein-coupled receptor activity
GO:0004969 histamine receptor activity
GO:0004993 G protein-coupled serotonin receptor activity
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007613 memory
GO:0008542 visual learning
GO:0030425 dendrite
GO:0030594 neurotransmitter receptor activity
GO:0032962 positive regulation of inositol trisphosphate biosynthetic process
GO:0043114 regulation of vascular permeability
GO:0045202 synapse
GO:0045907 positive regulation of vasoconstriction
GO:0048016 inositol phosphate-mediated signaling
GO:0048167 regulation of synaptic plasticity
GO:0048245 eosinophil chemotaxis
GO:0071420 cellular response to histamine

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000921 Histamine H1 receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00215 CitalopramDrugbanksmall molecule
DB00245 BenzatropineDrugbanksmall molecule
DB00246 ZiprasidoneDrugbanksmall molecule
DB00283 ClemastineDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00341 CetirizineDrugbanksmall molecule
DB00342 TerfenadineDrugbanksmall molecule
DB00354 BuclizineDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00366 DoxylamineDrugbanksmall molecule
DB00370 MirtazapineDrugbanksmall molecule
DB00405 DexbrompheniramineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00420 PromazineDrugbanksmall molecule
DB00427 TriprolidineDrugbanksmall molecule
DB00433 ProchlorperazineDrugbanksmall molecule
DB00434 CyproheptadineDrugbanksmall molecule
DB00455 LoratadineDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00502 HaloperidolDrugbanksmall molecule
DB00540 NortriptylineDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00555 LamotrigineDrugbanksmall molecule
DB00557 HydroxyzineDrugbanksmall molecule
DB00568 CinnarizineDrugbanksmall molecule
DB00637 AstemizoleDrugbanksmall molecule
DB00656 TrazodoneDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00719 AzatadineDrugbanksmall molecule
DB00726 TrimipramineDrugbanksmall molecule
DB00734 RisperidoneDrugbanksmall molecule
DB00737 MeclizineDrugbanksmall molecule
DB00748 CarbinoxamineDrugbanksmall molecule
DB00751 EpinastineDrugbanksmall molecule
DB00767 BenzquinamideDrugbanksmall molecule
DB00768 OlopatadineDrugbanksmall molecule
DB00777 PropiomazineDrugbanksmall molecule
DB00792 TripelennamineDrugbanksmall molecule
DB00797 TolazolineDrugbanksmall molecule
DB00835 BrompheniramineDrugbanksmall molecule
DB00902 MethdilazineDrugbanksmall molecule
DB00920 KetotifenDrugbanksmall molecule
DB00934 MaprotilineDrugbanksmall molecule
DB00950 FexofenadineDrugbanksmall molecule
DB00967 DesloratadineDrugbanksmall molecule
DB00972 AzelastineDrugbanksmall molecule
DB00985 DimenhydrinateDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01071 MequitazineDrugbanksmall molecule
DB01075 DiphenhydramineDrugbanksmall molecule
DB01084 EmedastineDrugbanksmall molecule
DB01106 LevocabastineDrugbanksmall molecule
DB01114 ChlorpheniramineDrugbanksmall molecule
DB01142 DoxepinDrugbanksmall molecule
DB01146 DiphenylpyralineDrugbanksmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB01173 OrphenadrineDrugbanksmall molecule
DB01175 EscitalopramDrugbanksmall molecule
DB01176 CyclizineDrugbanksmall molecule
DB01224 QuetiapineDrugbanksmall molecule
DB01237 BromodiphenhydramineDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01239 ChlorprothixeneDrugbanksmall molecule
DB01246 AlimemazineDrugbanksmall molecule
DB01267 PaliperidoneDrugbanksmall molecule
DB01403 MethotrimeprazineDrugbanksmall molecule
DB01615 AceprometazineDrugbanksmall molecule
DB01619 PhenindamineDrugbanksmall molecule
DB01620 PheniramineDrugbanksmall molecule
DB01624 ZuclopenthixolDrugbanksmall molecule
DB04837 ClofedanolDrugbanksmall molecule
DB04841 FlunarizineDrugbanksmall molecule
DB04890 BepotastineDrugbanksmall molecule
DB04905 TesmilifeneDrugbanksmall molecule
DB04946 IloperidoneDrugbanksmall molecule
DB05079 HY10275Drugbanksmall molecule
DB05080 OBE101Drugbanksmall molecule
DB05345 SO-101Drugbanksmall molecule
DB05381 HistamineDrugbanksmall molecule
DB05492 Epicept NP-1Drugbanksmall molecule
DB06016 CariprazineDrugbanksmall molecule
DB06148 MianserinDrugbanksmall molecule
DB06153 PizotifenDrugbanksmall molecule
DB06216 AsenapineDrugbanksmall molecule
DB06229 OcaperidoneDrugbanksmall molecule
DB06282 LevocetirizineDrugbanksmall molecule
DB06678 EsmirtazapineDrugbanksmall molecule
DB06691 MepyramineDrugbanksmall molecule
DB06698 BetahistineDrugbanksmall molecule
DB06766 AlcaftadineDrugbanksmall molecule
DB08799 AntazolineDrugbanksmall molecule
DB08800 ChloropyramineDrugbanksmall molecule
DB08801 DimetindeneDrugbanksmall molecule
DB08802 IsothipendylDrugbanksmall molecule
DB08922 PerospironeDrugbanksmall molecule
DB08936 ChlorcyclizineDrugbanksmall molecule
DB09016 ButriptylineDrugbanksmall molecule
DB09167 DosulepinDrugbanksmall molecule
DB09195 LorpiprazoleDrugbanksmall molecule
DB09488 AcrivastineDrugbanksmall molecule
DB09555 Dexchlorpheniramine maleateDrugbanksmall molecule
DB11235 ThonzylamineDrugbanksmall molecule
DB11591 BilastineDrugbanksmall molecule
DB11614 RupatadineDrugbanksmall molecule
DB14185 Aripiprazole lauroxilDrugbanksmall molecule