Entity Details

Primary name BMR1A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP36894
EntryNameBMR1A_HUMAN
FullNameBone morphogenetic protein receptor type-1A
TaxID9606
Evidenceevidence at protein level
Length532
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesBMPR1A

GO terms

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GOName
GO:0001649 osteoblast differentiation
GO:0001701 in utero embryonic development
GO:0001707 mesoderm formation
GO:0001756 somitogenesis
GO:0001880 Mullerian duct regression
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002062 chondrocyte differentiation
GO:0003148 outflow tract septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003161 cardiac conduction system development
GO:0003171 atrioventricular valve development
GO:0003183 mitral valve morphogenesis
GO:0003186 tricuspid valve morphogenesis
GO:0003203 endocardial cushion morphogenesis
GO:0003215 cardiac right ventricle morphogenesis
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003223 ventricular compact myocardium morphogenesis
GO:0003272 endocardial cushion formation
GO:0004674 protein serine/threonine kinase activity
GO:0005025 transforming growth factor beta receptor activity, type I
GO:0005524 ATP binding
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006955 immune response
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007398 ectoderm development
GO:0009897 external side of plasma membrane
GO:0009950 dorsal/ventral axis specification
GO:0009953 dorsal/ventral pattern formation
GO:0010629 negative regulation of gene expression
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014032 neural crest cell development
GO:0014912 negative regulation of smooth muscle cell migration
GO:0016021 integral component of membrane
GO:0019827 stem cell population maintenance
GO:0021983 pituitary gland development
GO:0021998 neural plate mediolateral regionalization
GO:0030324 lung development
GO:0030425 dendrite
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0032915 positive regulation of transforming growth factor beta2 production
GO:0035137 hindlimb morphogenesis
GO:0035912 dorsal aorta morphogenesis
GO:0036122 BMP binding
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042733 embryonic digit morphogenesis
GO:0042803 protein homodimerization activity
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0045669 positive regulation of osteoblast differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046332 SMAD binding
GO:0046872 metal ion binding
GO:0048352 paraxial mesoderm structural organization
GO:0048368 lateral mesoderm development
GO:0048378 regulation of lateral mesodermal cell fate specification
GO:0048382 mesendoderm development
GO:0048568 embryonic organ development
GO:0048589 developmental growth
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050768 negative regulation of neurogenesis
GO:0051148 negative regulation of muscle cell differentiation
GO:0060021 roof of mouth development
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060412 ventricular septum morphogenesis
GO:0060914 heart formation
GO:0060928 atrioventricular node cell development
GO:0061312 BMP signaling pathway involved in heart development
GO:0061626 pharyngeal arch artery morphogenesis
GO:0071363 cellular response to growth factor stimulus
GO:0071773 cellular response to BMP stimulus
GO:0098821 BMP receptor activity
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1904414 positive regulation of cardiac ventricle development
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1905285 fibrous ring of heart morphogenesis
GO:1990712 HFE-transferrin receptor complex
GO:2000772 regulation of cellular senescence

Subcellular Location

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Subcellular Location
Cell membrane
Cell surface

Domains

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DomainNameCategoryType
IPR000333 Ser/Thr protein kinase, TGFB receptorFamilyFamily
IPR000472 Activin types I and II receptor domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR003605 GS domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site

Diseases

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Drugs

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DrugNameSourceType
DB11639 Dibotermin alfaDrugbankbiotech

Interactions

61 interactions

InteractorPartnerSourcesPublicationsLink
BMR1A_HUMANBMP2_HUMANBioGRID, DIP, HPRD, IntAct, MINT10692589 10712517 10880444 10881198 11263668 15064755 16672363 18070108 19804412 20860622 21054789 25938661 details
BMR1A_HUMANGDF5_HUMANBioGRID, HPRD, IntAct, MINT, UniProt11282024 16127465 19229295 21543859 9525338 details
BMR1A_HUMANFSTL1_HUMANMINT20860622 details
BMR1A_HUMANBMP4_HUMANBioGRID, HPRD, MINT11241215 20860622 21054789 27684187 28126904 7644468 8006002 8702914 details
BMR1A_HUMANTRMO_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANALDOB_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANAMPO_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANMSD3_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANCDK8_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANCATL2_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANF16P2_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANFANCC_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANF16P1_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANGLT12_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANRASH_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANIBP3_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANSC61B_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANMP2K1_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANRASA1_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANSFRP2_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANSFRP4_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANSMAD1_HUMANBioGRID, HPRD, MINT11438941 24412244 9136927 details
BMR1A_HUMANTGFB1_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANXPA_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANZN189_HUMANBioGRID, MINT24412244 details
BMR1A_HUMANACVR1_HUMANBioGRID, IntAct18436533 26186194 28514442 details
BMR1A_HUMANSF3B4_HUMANBioGRID, HPRD15351706 details
BMR1A_HUMANFKB1B_HUMANBioGRID15351706 details
BMR1A_HUMANGDF6_HUMANBioGRID, HPRD9525338 details
BMR1A_HUMANBMP7_HUMANBioGRID, HPRD18070108 7791754 8006002 8605097 details
BMR1A_HUMANBMP6_HUMANBioGRID, HPRD10504300 11401330 18070108 details
BMR1A_HUMANFKB1A_HUMANBioGRID9663660 details
BMR1A_HUMANZMY11_HUMANBioGRID, HPRD9663660 details
BMR1A_HUMANBMR1A_HUMANBioGRID, HPRD10712517 18436533 details
BMR1A_HUMANNED4L_HUMANBioGRID19953087 details
BMR1A_HUMANNEDD4_HUMANBioGRID19953087 details
BMR1A_HUMANBAMBI_HUMANBioGRID19758997 details
BMR1A_HUMANUBP15_HUMANBioGRID24850914 details
BMR1A_HUMANOTUB1_HUMANBioGRID25872870 details
BMR1A_HUMANTDGF1_HUMANBioGRID28126904 details
BMR1A_HUMANTAB1_HUMANHPRD9663660 details
BMR1A_HUMANHS90B_HUMANBioGRID, IntAct22939624 27684187 details
BMR1A_HUMANSMAD7_HUMANBioGRID15148321 20663871 details
BMR1A_HUMANBMPR2_HUMANBioGRID, HPRD10712517 7791754 details
BMR1A_HUMANBMR1B_HUMANBioGRID, HPRD10712517 details
BMR1A_HUMANRUNX2_HUMANBioGRID16613856 details
BMR1A_HUMANT22D1_HUMANBioGRID21791611 details
BMR1A_HUMANIGSF1_HUMANBioGRID11266516 details
BMR1A_HUMANFST_HUMANBioGRID16198295 details
BMR1A_HUMANSMUF1_HUMANBioGRID12857866 details
BMR1A_HUMANSMAD6_HUMANBioGRID20663871 details
BMR1A_HUMANHS90A_HUMANBioGRID22939624 27684187 details
BMR1A_HUMANPEG10_HUMANBioGRID15611116 details
BMR1A_HUMANCAV1_HUMANBioGRID15657086 details
BMR1A_HUMANRGMB_HUMANBioGRID15671031 details
BMR1A_HUMANAVR2A_HUMANBioGRID15940369 details
BMR1A_HUMANPSDE_HUMANBioGRID31685442 details
BMR1A_HUMANBMP5_HUMANHPRD11580864 details
BMR1A_HUMANGDF9_HUMANHPRD10712517 12135884 details
BMR1A_HUMANTGFA1_HUMANHPRD11278302 details
BMR1A_HUMANHXC8_HUMANHPRD11139569 details