Entity Details

Primary name MLH1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP40692
EntryNameMLH1_HUMAN
FullNameDNA mismatch repair protein Mlh1
TaxID9606
Evidenceevidence at protein level
Length756
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesMLH1

GO terms

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GOName
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0000712 resolution of meiotic recombination intermediates
GO:0000795 synaptonemal complex
GO:0001673 male germ cell nucleus
GO:0003682 chromatin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005712 chiasma
GO:0005715 late recombination nodule
GO:0006298 mismatch repair
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0007060 male meiosis chromosome segregation
GO:0007129 homologous chromosome pairing at meiosis
GO:0007283 spermatogenesis
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009617 response to bacterium
GO:0016020 membrane
GO:0016321 female meiosis chromosome segregation
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0016887 ATP hydrolysis activity
GO:0019899 enzyme binding
GO:0032137 guanine/thymine mispair binding
GO:0032300 mismatch repair complex
GO:0032389 MutLalpha complex
GO:0043060 meiotic metaphase I plate congression
GO:0045141 meiotic telomere clustering
GO:0045190 isotype switching
GO:0045950 negative regulation of mitotic recombination
GO:0048298 positive regulation of isotype switching to IgA isotypes
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0048477 oogenesis
GO:0051257 meiotic spindle midzone assembly

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR002099 DNA mismatch repair protein family, N-terminalDomainDomain
IPR013507 DNA mismatch repair protein, S5 domain 2-likeDomainDomain
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroupFamilyHomologous superfamily
IPR014762 DNA mismatch repair, conserved siteSiteConserved site
IPR020568 Ribosomal protein S5 domain 2-type foldFamilyHomologous superfamily
IPR032189 DNA mismatch repair protein Mlh1, C-terminalDomainDomain
IPR036890 Histidine kinase/HSP90-like ATPase superfamilyFamilyHomologous superfamily
IPR038973 DNA mismatch repair protein MutL/Mlh/PmsFamilyFamily

Diseases

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Interactions

207 interactions

InteractorPartnerSourcesPublicationsLink
MLH1_HUMANAP2B1_HUMANBioGRID, HPRD, IntAct16189514 25910212 27107012 32296183 details
MLH1_HUMANTRI29_HUMANBioGRID, HPRD, IntAct16189514 26095369 details
MLH1_HUMANZC11A_HUMANBioGRID, HPRD, IntAct16189514 19060904 27229929 29892012 31515488 details
MLH1_HUMANFRMD6_HUMANBioGRID, HPRD, IntAct16189514 28514442 29892012 31515488 32296183 details
MLH1_HUMANRNF37_HUMANBioGRID, HPRD, IntAct16189514 27229929 29892012 31515488 32296183 details
MLH1_HUMANPMS2_HUMANBioGRID, DIP, HPRD, IntAct, MINT10037723 10748159 11292842 11429708 11793469 12584560 12799449 12810663 14676842 15225546 16083711 17148452 17581638 18206974 18768816 19015241 20533529 20706999 20978114 22252508 22939629 25077178 25502805 26496610 30770470 31515488 details
MLH1_HUMANFANCJ_HUMANBioGRID, IntAct, MINT16391231 17148452 17581638 20173781 20978114 22792074 22968820 23585563 24573678 24966277 25502805 details
MLH1_HUMANTYB4_HUMANBioGRID, IntAct17967441 20706999 details
MLH1_HUMANMUC2_HUMANIntAct20706999 details
MLH1_HUMANZER1_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANDHB3_HUMANIntAct20706999 details
MLH1_HUMANFLNC_HUMANIntAct20706999 details
MLH1_HUMANTPRGL_HUMANIntAct20706999 details
MLH1_HUMANCUTA_HUMANIntAct20706999 details
MLH1_HUMANCOPA_HUMANIntAct20706999 details
MLH1_HUMANCLIC1_HUMANIntAct20706999 details
MLH1_HUMANVPS51_HUMANIntAct20706999 details
MLH1_HUMANACON_HUMANIntAct20706999 details
MLH1_HUMANPTGDS_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANVAMP8_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANFCGBP_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANMRP3_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANFBX32_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANSQSTM_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANAGR2_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANEIF2A_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANIGKC_HUMANIntAct20706999 details
MLH1_HUMANAPT_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANABHGA_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANEF2_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANLEG4_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANPARVA_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANSPTN1_HUMANBioGRID, IntAct20706999 26344197 details
MLH1_HUMANMYL6_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANCKAP4_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANFLNB_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANACTG_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANACTH_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANANXA2_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANDESM_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANTHIOM_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANMP2K6_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANNDRG1_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANSTAP2_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANCAN5_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANCATB_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANGBRAP_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANARAF_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANANXA6_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANAIFM1_HUMANBioGRID, IntAct17148452 20706999 details
MLH1_HUMANRPGFL_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANRD23B_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANPAR12_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANTRI23_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANDDX47_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANCB39L_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANASSY_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANKCRB_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANEXOC3_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANALDOA_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANS61A1_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANPEDF_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANSBP1_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANGSTP1_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANACER3_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANELP6_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANSCMC3_HUMANIntAct20706999 details
MLH1_HUMANTP4A2_HUMANIntAct20706999 details
MLH1_HUMAN5NT3B_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANPLPP2_HUMANIntAct20706999 details
MLH1_HUMANPTPRH_HUMANBioGRID, IntAct20706999 details
MLH1_HUMANRS5_HUMANIntAct20706999 details
MLH1_HUMANRRBP1_HUMANIntAct20706999 details
MLH1_HUMANRS16_HUMANIntAct20706999 details
MLH1_HUMANNDUS8_HUMANIntAct20706999 details
MLH1_HUMANNFIP2_HUMANIntAct20706999 details
MLH1_HUMANNONO_HUMANIntAct20706999 details
MLH1_HUMANRS2_HUMANIntAct20706999 details
MLH1_HUMANI20RA_HUMANIntAct20706999 details
MLH1_HUMANNCF4_HUMANIntAct20706999 details
MLH1_HUMANBRCA1_HUMANBioGRID, HPRD, MINT, UniProt10783165 16786532 17148452 21240188 25184681 29656893 details
MLH1_HUMANRADX_HUMANBioGRID, IntAct, MINT21516116 25416956 27229929 31515488 32296183 details
MLH1_HUMANCBY2_HUMANBioGRID, IntAct, MINT21516116 25416956 25910212 27107012 29892012 31515488 32296183 details
MLH1_HUMANATF2_HUMANBioGRID, IntAct21988832 details
MLH1_HUMANORC4_HUMANBioGRID, IntAct21988832 details
MLH1_HUMANTHIO_HUMANBioGRID, IntAct21988832 details
MLH1_HUMANALDOB_HUMANBioGRID, MINT24412244 details
MLH1_HUMANBAAT_HUMANBioGRID, MINT24412244 details
MLH1_HUMANTRMO_HUMANBioGRID, MINT24412244 details
MLH1_HUMANCATL2_HUMANBioGRID, MINT24412244 details
MLH1_HUMANCYLC2_HUMANBioGRID, MINT24412244 details
MLH1_HUMANFRAT2_HUMANBioGRID, MINT24412244 details
MLH1_HUMANCC180_HUMANBioGRID, MINT24412244 details
MLH1_HUMANLEF1_HUMANBioGRID, MINT24412244 details
MLH1_HUMANPP2AB_HUMANBioGRID, MINT24412244 details
MLH1_HUMANSMAD1_HUMANBioGRID, MINT24412244 details
MLH1_HUMANSTX17_HUMANBioGRID, MINT24412244 details
MLH1_HUMANTDRD7_HUMANBioGRID, MINT24412244 details
MLH1_HUMANXPA_HUMANBioGRID, MINT24412244 details
MLH1_HUMANEXO1_HUMANBioGRID, HPRD, IntAct, UniProt11427529 11429708 12414623 12810663 14676842 17148452 19015241 21533173 22222486 32814904 details
MLH1_HUMANMSH3_HUMANBioGRID, IntAct17148452 25416956 29892012 31515488 details
MLH1_HUMANPSA1_HUMANBioGRID, IntAct25416956 29892012 31515488 details
MLH1_HUMANMYOG_HUMANBioGRID, IntAct25416956 25910212 29892012 31515488 32296183 details
MLH1_HUMANIMA1_HUMANBioGRID, IntAct17148452 25416956 29892012 31515488 32296183 details
MLH1_HUMANPMS1_HUMANBioGRID, HPRD, IntAct10748159 11292842 17148452 20004149 25502805 26496610 details
MLH1_HUMANFAN1_HUMANBioGRID, IntAct17148452 20603015 20603073 25659891 26496610 27880917 29051491 32296183 details
MLH1_HUMANCDKL5_HUMANBioGRID, IntAct, MINT21653829 32296183 details
MLH1_HUMANZN212_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANNFIX_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANAP1B1_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANPER2_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANPTN3_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANBTBD2_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANRSPH3_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANAP2D_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANZFP90_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANNDKM_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANCC74B_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANF228A_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANSYF2_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANZN177_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANFA50B_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANTLE5_HUMANBioGRID, IntAct27229929 32296183 details
MLH1_HUMANRBM48_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANU2AF5_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANMORN3_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANISY1_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANNANO3_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANZMAT5_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANPRR5L_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANSPAT8_HUMANIntAct32296183 details
MLH1_HUMANMAGA8_HUMANBioGRID, IntAct25910212 27229929 32296183 details
MLH1_HUMANCDA7L_HUMANBioGRID, IntAct27229929 32296183 details
MLH1_HUMANTSG13_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANASPP1_HUMANBioGRID, IntAct32296183 details
MLH1_HUMAN3MG_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANMBD4_HUMANBioGRID, HPRD, IntAct10097147 25358258 32296183 details
MLH1_HUMANTASO2_HUMANBioGRID, IntAct25910212 32296183 details
MLH1_HUMANENKD1_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANKPRP_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANCI152_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANZFP57_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANMB3L1_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANLC7L3_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANNELFA_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANZN774_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANPI42B_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANF90A1_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANZN474_HUMANBioGRID, IntAct32296183 details
MLH1_HUMANMLH3_HUMANBioGRID, HPRD, IntAct10615123 11292842 24443562 27229929 32814343 details
MLH1_HUMANBLM_HUMANBioGRID, HPRD10783165 11325959 11470874 11691925 12724401 19015241 21466675 details
MLH1_HUMANMYC_HUMANBioGRID, HPRD12584560 29467282 details
MLH1_HUMANMSH4_HUMANBioGRID, HPRD10928988 32814904 details
MLH1_HUMANPOLH_HUMANBioGRID19703417 details
MLH1_HUMANEF1G_HUMANBioGRID20706999 details
MLH1_HUMANPCNA_HUMANBioGRID15225546 28439008 32814904 details
MLH1_HUMANCCD33_HUMANBioGRID25910212 27229929 32296183 details
MLH1_HUMANCEP76_HUMANBioGRID27229929 details
MLH1_HUMANCE126_HUMANBioGRID27229929 details
MLH1_HUMANLY96_HUMANBioGRID27229929 details
MLH1_HUMANZBED1_HUMANBioGRID27229929 details
MLH1_HUMANHDAC6_HUMANBioGRID24882211 30770470 details
MLH1_HUMANU2AF1_HUMANBioGRID32296183 details
MLH1_HUMANIMA6_HUMANBioGRID32296183 details
MLH1_HUMANMSH5_HUMANBioGRID32814904 details
MLH1_HUMANFSCN1_HUMANIntAct20603015 details
MLH1_HUMANH2AX_HUMANBioGRID, IntAct22094255 26095369 details
MLH1_HUMANMSH2_HUMANBioGRID, IntAct10748159 10783165 12799449 25241761 30770470 31843968 details
MLH1_HUMANCASP3_HUMANBioGRID, HPRD, IntAct15087450 25241761 details
MLH1_HUMANHSP7C_HUMANIntAct25502805 details
MLH1_HUMANATM_HUMANBioGRID10783165 details
MLH1_HUMANMRE11_HUMANBioGRID10783165 details
MLH1_HUMANMSH6_HUMANBioGRID10748159 10783165 12799449 30770470 details
MLH1_HUMANNBN_HUMANBioGRID10783165 17121922 details
MLH1_HUMANRAD50_HUMANBioGRID10783165 details
MLH1_HUMANRFC1_HUMANBioGRID10783165 details
MLH1_HUMANSMC1A_HUMANBioGRID17148452 details
MLH1_HUMANXRN1_HUMANBioGRID17148452 details
MLH1_HUMANPSD3_HUMANBioGRID17148452 details
MLH1_HUMANUBC_HUMANBioGRID17148452 details
MLH1_HUMANUBP2L_HUMANBioGRID17148452 details
MLH1_HUMANYLPM1_HUMANBioGRID17148452 details
MLH1_HUMANPRKDC_HUMANBioGRID17148452 details
MLH1_HUMANIMB1_HUMANBioGRID17148452 details
MLH1_HUMANRUVB1_HUMANBioGRID17148452 details
MLH1_HUMANRUVB2_HUMANBioGRID17148452 details
MLH1_HUMAN2AAA_HUMANBioGRID17148452 details
MLH1_HUMAN2ABA_HUMANBioGRID17148452 details
MLH1_HUMAN2ABB_HUMANBioGRID17148452 details
MLH1_HUMANPP2BB_HUMANBioGRID17148452 details
MLH1_HUMANPP2BC_HUMANBioGRID17148452 details
MLH1_HUMAN2ABD_HUMANBioGRID17148452 details
MLH1_HUMANP3C2A_HUMANBioGRID17148452 details
MLH1_HUMANAMOT_HUMANBioGRID17148452 details
MLH1_HUMANATD3A_HUMANBioGRID17148452 details
MLH1_HUMANDOCK7_HUMANBioGRID17148452 details
MLH1_HUMANPYGB_HUMANBioGRID17148452 details
MLH1_HUMANATPA_HUMANBioGRID17148452 details
MLH1_HUMANATD3B_HUMANBioGRID17148452 details
MLH1_HUMANWDR61_HUMANBioGRID17148452 details
MLH1_HUMANBARD1_HUMANBioGRID16391231 details
MLH1_HUMANFACD2_HUMANBioGRID21865299 details
MLH1_HUMANSPRTN_HUMANBioGRID23042605 details
MLH1_HUMANMCM9_HUMANBioGRID26300262 26870752 details
MLH1_HUMANMCM8_HUMANBioGRID26300262 details
MLH1_HUMANSMRCD_HUMANBioGRID31843968 details
MLH1_HUMANRAD9A_HUMANHPRD18842633 details