Entity Details

Primary name OPRD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41143
EntryNameOPRD_HUMAN
FullNameDelta-type opioid receptor
TaxID9606
Evidenceevidence at protein level
Length372
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesOPRD1

GO terms

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GOName
GO:0004930 G protein-coupled receptor activity
GO:0004985 G protein-coupled opioid receptor activity
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006955 immune response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0008344 adult locomotory behavior
GO:0010629 negative regulation of gene expression
GO:0019221 cytokine-mediated signaling pathway
GO:0030285 integral component of synaptic vesicle membrane
GO:0031226 intrinsic component of plasma membrane
GO:0031333 negative regulation of protein-containing complex assembly
GO:0032590 dendrite membrane
GO:0032793 positive regulation of CREB transcription factor activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033612 receptor serine/threonine kinase binding
GO:0038003 G protein-coupled opioid receptor signaling pathway
GO:0038046 G protein-coupled enkephalin receptor activity
GO:0042277 peptide binding
GO:0042755 eating behavior
GO:0042923 neuropeptide binding
GO:0043005 neuron projection
GO:0043679 axon terminus
GO:0045121 membrane raft
GO:0051881 regulation of mitochondrial membrane potential
GO:0051924 regulation of calcium ion transport
GO:0051930 regulation of sensory perception of pain
GO:0071363 cellular response to growth factor stimulus
GO:0071456 cellular response to hypoxia
GO:0097237 cellular response to toxic substance
GO:0097444 spine apparatus
GO:0098992 neuronal dense core vesicle
GO:0099056 integral component of presynaptic membrane
GO:0099061 integral component of postsynaptic density membrane

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000321 Delta opioid receptorFamilyFamily
IPR001418 Opioid receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00193 TramadolDrugbanksmall molecule
DB00295 MorphineDrugbanksmall molecule
DB00318 CodeineDrugbanksmall molecule
DB00321 AmitriptylineDrugbanksmall molecule
DB00327 HydromorphoneDrugbanksmall molecule
DB00333 MethadoneDrugbanksmall molecule
DB00497 OxycodoneDrugbanksmall molecule
DB00514 DextromethorphanDrugbanksmall molecule
DB00611 ButorphanolDrugbanksmall molecule
DB00647 DextropropoxypheneDrugbanksmall molecule
DB00704 NaltrexoneDrugbanksmall molecule
DB00708 SufentanilDrugbanksmall molecule
DB00813 FentanylDrugbanksmall molecule
DB00836 LoperamideDrugbanksmall molecule
DB00844 NalbuphineDrugbanksmall molecule
DB00854 LevorphanolDrugbanksmall molecule
DB00899 RemifentanilDrugbanksmall molecule
DB00921 BuprenorphineDrugbanksmall molecule
DB00956 HydrocodoneDrugbanksmall molecule
DB01081 DiphenoxylateDrugbanksmall molecule
DB01183 NaloxoneDrugbanksmall molecule
DB01192 OxymorphoneDrugbanksmall molecule
DB01221 KetamineDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01439 3-MethylthiofentanylDrugbanksmall molecule
DB01444 DimethylthiambuteneDrugbanksmall molecule
DB01452 DiamorphineDrugbanksmall molecule
DB01497 EtorphineDrugbanksmall molecule
DB01535 CarfentanilDrugbanksmall molecule
DB01548 DiprenorphineDrugbanksmall molecule
DB01565 DihydromorphineDrugbanksmall molecule
DB01571 3-MethylfentanylDrugbanksmall molecule
DB05050 ADL5859Drugbanksmall molecule
DB06204 TapentadolDrugbanksmall molecule
DB06230 NalmefeneDrugbanksmall molecule
DB06274 AlvimopanDrugbanksmall molecule
DB06409 Morphine glucuronideDrugbanksmall molecule
DB06738 KetobemidoneDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09173 ButyrfentanylDrugbanksmall molecule
DB09209 PholcodineDrugbanksmall molecule
DB09272 EluxadolineDrugbanksmall molecule
DB11130 OpiumDrugbanksmall molecule
DB11691 NaldemedineDrugbanksmall molecule
DB12668 MetenkefalinDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule
DB14146 LoxicodegolDrugbanksmall molecule

Interactions

35 interactions

InteractorPartnerSourcesPublicationsLink
OPRD_HUMANGASP1_HUMANBioGRID, IntAct12142540 15086532 details
OPRD_HUMANS13A4_HUMANBioGRID, IntAct32296183 details
OPRD_HUMANSMAGP_HUMANBioGRID, IntAct32296183 details
OPRD_HUMANCTXN3_HUMANBioGRID, IntAct32296183 details
OPRD_HUMANTM237_HUMANBioGRID, IntAct32296183 details
OPRD_HUMANRPRM_HUMANBioGRID, IntAct32296183 details
OPRD_HUMANS12A7_HUMANBioGRID, IntAct32296183 details
OPRD_HUMANOPRD_HUMANBioGRID11278447 details
OPRD_HUMANADRB2_HUMANBioGRID, HPRD11278447 details
OPRD_HUMANARRB1_HUMANBioGRID, HPRD11259507 details
OPRD_HUMANARRB2_HUMANBioGRID, HPRD11259507 details
OPRD_HUMANAT2A2_HUMANMINT20528919 details
OPRD_HUMANCALX_HUMANBioGRID, MINT11054417 20528919 details
OPRD_HUMANOPRM_HUMANBioGRID, HPRD11069979 21220103 details
OPRD_HUMANGNAO_HUMANBioGRID, HPRD11259487 8393523 details
OPRD_HUMANHSP74_HUMANBioGRID11054417 details
OPRD_HUMANS61A1_HUMANBioGRID11054417 details
OPRD_HUMANAUP1_HUMANBioGRID23840749 details
OPRD_HUMANCXA4_HUMANBioGRID23840749 details
OPRD_HUMANDOK4_HUMANBioGRID23840749 details
OPRD_HUMANSIAH1_HUMANBioGRID23840749 details
OPRD_HUMANSIAH2_HUMANBioGRID23840749 details
OPRD_HUMANVAPA_HUMANBioGRID23840749 details
OPRD_HUMANWLS_HUMANBioGRID23840749 details
OPRD_HUMANSSR4_HUMANBioGRID24416361 details
OPRD_HUMANOPRK_HUMANHPRD11069979 details
OPRD_HUMANKPCA_HUMANHPRD11085981 details
OPRD_HUMANKPCE_HUMANHPRD11085981 details
OPRD_HUMANKPCD_HUMANHPRD11085981 details
OPRD_HUMANKLHL3_HUMANHPRD11259487 details
OPRD_HUMANARBK1_HUMANHPRD11040053 details
OPRD_HUMANGNAZ_HUMANHPRD9166747 details
OPRD_HUMANGNAI1_HUMANHPRD11259487 details
OPRD_HUMANGNA15_HUMANHPRD14535952 details
OPRD_HUMANGNAI2_HUMANHPRD1671672 details