Entity Details

Primary name CCR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP41597
EntryNameCCR2_HUMAN
FullNameC-C chemokine receptor type 2
TaxID9606
Evidenceevidence at protein level
Length374
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesCCR2

GO terms

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GOName
GO:0001974 blood vessel remodeling
GO:0002407 dendritic cell chemotaxis
GO:0002724 regulation of T cell cytokine production
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0002829 negative regulation of type 2 immune response
GO:0004950 chemokine receptor activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006874 cellular calcium ion homeostasis
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0006968 cellular defense response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0009611 response to wounding
GO:0009897 external side of plasma membrane
GO:0010574 regulation of vascular endothelial growth factor production
GO:0010820 positive regulation of T cell chemotaxis
GO:0016021 integral component of membrane
GO:0016032 viral process
GO:0016493 C-C chemokine receptor activity
GO:0016525 negative regulation of angiogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0019233 sensory perception of pain
GO:0019722 calcium-mediated signaling
GO:0019725 cellular homeostasis
GO:0019957 C-C chemokine binding
GO:0030425 dendrite
GO:0031727 CCR2 chemokine receptor binding
GO:0032729 positive regulation of interferon-gamma production
GO:0032743 positive regulation of interleukin-2 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0035696 monocyte extravasation
GO:0035705 T-helper 17 cell chemotaxis
GO:0042802 identical protein binding
GO:0043025 neuronal cell body
GO:0043204 perikaryon
GO:0043310 negative regulation of eosinophil degranulation
GO:0045580 regulation of T cell differentiation
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0048471 perinuclear region of cytoplasm
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050870 positive regulation of T cell activation
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060326 cell chemotaxis
GO:0070098 chemokine-mediated signaling pathway
GO:0090026 positive regulation of monocyte chemotaxis
GO:0090265 positive regulation of immune complex clearance by monocytes and macrophages
GO:0090594 inflammatory response to wounding
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1904783 positive regulation of NMDA glutamate receptor activity
GO:1905517 macrophage migration
GO:2000412 positive regulation of thymocyte migration
GO:2000439 positive regulation of monocyte extravasation
GO:2000451 positive regulation of CD8-positive, alpha-beta T cell extravasation
GO:2000464 positive regulation of astrocyte chemotaxis
GO:2000473 positive regulation of hematopoietic stem cell migration

Subcellular Location

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Subcellular Location
Cell membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000355 Chemokine receptor familyFamilyFamily
IPR002237 CC chemokine receptor 2FamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB05130 INCB3284Drugbanksmall molecule
DB05159 CCX915Drugbanksmall molecule
DB12520 PlozalizumabDrugbankbiotech

Interactions

51 interactions

InteractorPartnerSourcesPublicationsLink
CCR2_HUMANNUP85_HUMANMINT25283965 details
CCR2_HUMANPRAF3_HUMANBioGRID, MINT28298427 details
CCR2_HUMANCD81_HUMANBioGRID, MINT28298427 details
CCR2_HUMANCD59_HUMANBioGRID, MINT28298427 details
CCR2_HUMANCYBP_HUMANBioGRID, MINT28298427 details
CCR2_HUMANB3GA3_HUMANBioGRID, MINT28298427 details
CCR2_HUMANAT2B1_HUMANBioGRID, MINT28298427 details
CCR2_HUMANA4_HUMANBioGRID, MINT28298427 details
CCR2_HUMANHERP1_HUMANBioGRID, MINT28298427 details
CCR2_HUMANCLPT1_HUMANBioGRID, MINT28298427 details
CCR2_HUMANDMWD_HUMANBioGRID, MINT28298427 details
CCR2_HUMANS1PR5_HUMANBioGRID, MINT28298427 details
CCR2_HUMANHMOX2_HUMANBioGRID, MINT28298427 details
CCR2_HUMANAATC_HUMANBioGRID, MINT28298427 details
CCR2_HUMANWLS_HUMANBioGRID, MINT28298427 details
CCR2_HUMANGP161_HUMANBioGRID, MINT28298427 details
CCR2_HUMANEMC10_HUMANBioGRID, MINT28298427 details
CCR2_HUMANCDIP1_HUMANBioGRID, MINT28298427 details
CCR2_HUMANERGI3_HUMANBioGRID, MINT28298427 details
CCR2_HUMANNFIP1_HUMANBioGRID, MINT28298427 details
CCR2_HUMANTCPR2_HUMANBioGRID, MINT28298427 details
CCR2_HUMANJPH3_HUMANBioGRID, MINT28298427 details
CCR2_HUMAN7B2_HUMANBioGRID, MINT28298427 details
CCR2_HUMANRGR_HUMANBioGRID, MINT28298427 details
CCR2_HUMANRTN3_HUMANBioGRID, MINT28298427 details
CCR2_HUMANRHOG_HUMANBioGRID, MINT28298427 details
CCR2_HUMANPIMT_HUMANBioGRID, MINT28298427 details
CCR2_HUMANPTN9_HUMANBioGRID, MINT28298427 details
CCR2_HUMANPLLP_HUMANBioGRID, MINT28298427 details
CCR2_HUMANBL1S6_HUMANBioGRID, MINT28298427 details
CCR2_HUMANNOTC2_HUMANBioGRID, MINT28298427 details
CCR2_HUMANNTNG2_HUMANBioGRID, MINT28298427 details
CCR2_HUMANSUMO1_HUMANBioGRID, MINT28298427 details
CCR2_HUMANGTR1_HUMANBioGRID, MINT28298427 details
CCR2_HUMANSRSF5_HUMANBioGRID, MINT28298427 details
CCR2_HUMANS41A3_HUMANBioGRID, MINT28298427 details
CCR2_HUMANTM199_HUMANBioGRID, MINT28298427 details
CCR2_HUMANT161A_HUMANBioGRID, MINT28298427 details
CCR2_HUMANTSN7_HUMANBioGRID, MINT28298427 details
CCR2_HUMANSVOP_HUMANBioGRID, MINT28298427 details
CCR2_HUMANCSCL1_HUMANBioGRID, MINT28298427 details
CCR2_HUMANCCL11_HUMANHPRD11264152 details
CCR2_HUMANCCR5_HUMANHPRD11350939 details
CCR2_HUMANCCL13_HUMANHPRD12149192 9195948 details
CCR2_HUMANCCL16_HUMANHPRD11470772 details
CCR2_HUMANCCL8_HUMANHPRD12149192 9115216 details
CCR2_HUMANTPST1_HUMANHPRD17558413 details
CCR2_HUMANTPST2_HUMANHPRD17558413 details
CCR2_HUMANJAK2_HUMANHPRD9670957 details
CCR2_HUMANCCL2_HUMANHPRD10529171 9287323 details
CCR2_HUMANCCL7_HUMANHPRD8530354 details