Entity Details

Primary name PK3CB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42338
EntryNamePK3CB_HUMAN
FullNamePhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
TaxID9606
Evidenceevidence at protein level
Length1070
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesPIK3CB

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000187 obsolete activation of MAPK activity
GO:0001952 regulation of cell-matrix adhesion
GO:0002931 response to ischemia
GO:0003376 sphingosine-1-phosphate receptor signaling pathway
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005942 phosphatidylinositol 3-kinase complex
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006897 endocytosis
GO:0006914 autophagy
GO:0006935 chemotaxis
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007411 axon guidance
GO:0010508 positive regulation of autophagy
GO:0010595 positive regulation of endothelial cell migration
GO:0010628 positive regulation of gene expression
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016020 membrane
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0019221 cytokine-mediated signaling pathway
GO:0030168 platelet activation
GO:0030496 midbody
GO:0033031 positive regulation of neutrophil apoptotic process
GO:0035004 phosphatidylinositol 3-kinase activity
GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0035022 positive regulation of Rac protein signal transduction
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043231 intracellular membrane-bounded organelle
GO:0043407 negative regulation of MAP kinase activity
GO:0046854 phosphatidylinositol phosphate biosynthetic process
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0051898 negative regulation of protein kinase B signaling
GO:0052742 phosphatidylinositol kinase activity
GO:0052812 phosphatidylinositol-3,4-bisphosphate 5-kinase activity
GO:0070527 platelet aggregation
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway
GO:1903671 negative regulation of sprouting angiogenesis
GO:2000369 regulation of clathrin-dependent endocytosis

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domainDomainDomain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domainDomainDomain
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domainDomainDomain
IPR002420 C2 phosphatidylinositol 3-kinase-type domainDomainDomain
IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015433 Phosphatidylinositol kinaseFamilyFamily
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR018936 Phosphatidylinositol 3/4-kinase, conserved siteSiteConserved site
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamilyFamilyHomologous superfamily
IPR037702 PI3Kbeta, catalytic domainDomainDomain
IPR042236 Phosphoinositide 3-kinase, accessory (PIK) domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00201 CaffeineDrugbanksmall molecule
DB05241 XL765Drugbanksmall molecule

Interactions

26 interactions

InteractorPartnerSourcesPublicationsLink
PK3CB_HUMAN1433T_HUMANHPRD, MINT7479742 details
PK3CB_HUMANHEM1_HUMANBioGRID, MINT21900206 details
PK3CB_HUMANDVL3_HUMANBioGRID, MINT21900206 details
PK3CB_HUMANHPS6_HUMANBioGRID, MINT21900206 details
PK3CB_HUMANP55G_HUMANBioGRID, IntAct22402981 25814554 28514442 details
PK3CB_HUMANP85A_HUMANBioGRID, DIP, HPRD, IntAct10358930 20713702 21825134 22939629 24657164 25241761 26344197 26496610 26839216 27107012 32814053 8139559 details
PK3CB_HUMANA4_HUMANIntAct32814053 details
PK3CB_HUMANARBK1_HUMANBioGRID12163475 details
PK3CB_HUMANRAB5B_HUMANBioGRID11432782 details
PK3CB_HUMANLRRK2_HUMANBioGRID25854701 details
PK3CB_HUMANP85B_HUMANBioGRID, IntAct19380743 22402981 26186194 28514442 details
PK3CB_HUMANCBL_HUMANBioGRID, IntAct14530346 19380743 details
PK3CB_HUMANTFCP2_HUMANIntAct20195357 details
PK3CB_HUMANHCK_HUMANBioGRID, HPRD, IntAct12029088 23397142 25241761 details
PK3CB_HUMANNBN_HUMANDIP20368419 details
PK3CB_HUMANKPCD_HUMANBioGRID, HPRD11676480 details
PK3CB_HUMANKPCE_HUMANBioGRID, HPRD9822674 details
PK3CB_HUMANALK_HUMANBioGRID14968112 details
PK3CB_HUMANRAB5A_HUMANBioGRID15328530 details
PK3CB_HUMANGAB2_HUMANBioGRID14530346 details
PK3CB_HUMANIRS1_HUMANBioGRID23604317 29526746 details
PK3CB_HUMANEGFR_HUMANBioGRID23956138 25754235 31959764 details
PK3CB_HUMANWDR26_HUMANBioGRID26895380 details
PK3CB_HUMANGBB1_HUMANBioGRID26895380 details
PK3CB_HUMANAGTR2_HUMANHPRD11459796 details
PK3CB_HUMANNEP_HUMANHPRD12529960 details