Entity Details

Primary name NAMPT_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP43490
EntryNameNAMPT_HUMAN
FullNameNicotinamide phosphoribosyltransferase
TaxID9606
Evidenceevidence at protein level
Length491
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesNAMPT

GO terms

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GOName
GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:0005125 cytokine activity
GO:0005829 cytosol
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008284 positive regulation of cell population proliferation
GO:0016607 nuclear speck
GO:0030054 cell junction
GO:0032922 circadian regulation of gene expression
GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway
GO:0042802 identical protein binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0047280 nicotinamide phosphoribosyltransferase activity
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR013785 Aldolase-type TIM barrelFamilyHomologous superfamily
IPR016471 Nicotinamide phosphoribosyl transferaseFamilyFamily
IPR036068 Nicotinate phosphoribosyltransferase-like, C-terminalFamilyHomologous superfamily
IPR041525 Nicotinate/nicotinamide phosphoribosyltransferaseDomainDomain
IPR041529 Nicotinamide phosphoribosyltransferase, N-terminal domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB05217 GMX1777Drugbanksmall molecule
DB12731 DaporinadDrugbanksmall molecule