Entity Details

Primary name PRS6B_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP43686
EntryNamePRS6B_HUMAN
FullName26S proteasome regulatory subunit 6B
TaxID9606
Evidenceevidence at protein level
Length418
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesPSMC4

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0000209 protein polyubiquitination
GO:0000502 proteasome complex
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006508 proteolysis
GO:0006521 regulation of cellular amino acid metabolic process
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0016020 membrane
GO:0016234 inclusion body
GO:0016579 protein deubiquitination
GO:0016887 ATP hydrolysis activity
GO:0022624 proteasome accessory complex
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031597 cytosolic proteasome complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0036388 pre-replicative complex assembly
GO:0036402 proteasome-activating activity
GO:0038061 NIK/NF-kappaB signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043488 regulation of mRNA stability
GO:0043687 post-translational protein modification
GO:0045202 synapse
GO:0045899 positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:0050852 T cell receptor signaling pathway
GO:0055085 transmembrane transport
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070498 interleukin-1-mediated signaling pathway
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1902036 regulation of hematopoietic stem cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR003593 AAA+ ATPase domainDomainDomain
IPR003959 ATPase, AAA-type, coreDomainDomain
IPR003960 ATPase, AAA-type, conserved siteSiteConserved site
IPR005937 26S proteasome regulatory subunit P45-likeFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR032501 Proteasomal ATPase OB C-terminal domainDomainDomain
IPR035256 26S Proteasome regulatory subunit 6BFamilyFamily
IPR041569 AAA ATPase, AAA+ lid domainDomainDomain

Diseases

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Interactions

57 interactions

InteractorPartnerSourcesPublicationsLink
PRS6B_HUMANPRS8_HUMANBioGRID, HPRD, IntAct15604093 16189514 17353931 19490896 19781552 22275368 22863883 22939629 26344197 28292943 28514442 29892012 31515488 32296183 details
PRS6B_HUMANPSD10_HUMANBioGRID, HPRD, IntAct11779854 12525503 16189514 17353931 19412159 19490896 21988832 22939629 24338975 25416956 26344197 28514442 32296183 details
PRS6B_HUMANPRS7_HUMANBioGRID, HPRD, IntAct11361004 17353931 21628461 22275368 22863883 22901813 22939629 26344197 28292943 28514442 details
PRS6B_HUMANPRS4_HUMANBioGRID, IntAct17353931 19490896 20810900 21628461 22275368 22863883 22939629 26344197 26496610 28292943 28514442 details
PRS6B_HUMANPSMD7_HUMANBioGRID, IntAct17353931 19615732 22863883 22939629 26186194 26344197 28292943 28514442 32157086 details
PRS6B_HUMANPRS6A_HUMANBioGRID, HPRD, IntAct11463857 17353931 22275368 22863883 22939629 26186194 26344197 28292943 28514442 8419915 details
PRS6B_HUMANPRS10_HUMANBioGRID, DIP, IntAct19490896 22275368 22939629 26344197 27342858 28292943 28514442 29636472 details
PRS6B_HUMANNPM_HUMANBioGRID, IntAct21988832 23402259 details
PRS6B_HUMANPSDE_HUMANBioGRID, IntAct17323924 22863883 22939629 26344197 26496610 27428775 28292943 28821611 30745168 32157086 32631902 details
PRS6B_HUMANPSD12_HUMANBioGRID, IntAct22863883 22939629 26344197 28292943 28514442 details
PRS6B_HUMANCDC42_HUMANIntAct21311754 details
PRS6B_HUMANODO2_HUMANBioGRID, IntAct29128334 32814053 details
PRS6B_HUMANCALR_HUMANIntAct32814053 details
PRS6B_HUMANNEK7_HUMANIntAct32814053 details
PRS6B_HUMANSODC_HUMANIntAct32814053 details
PRS6B_HUMANRING2_HUMANBioGRID15773819 details
PRS6B_HUMANUBC_HUMANBioGRID16196087 28190767 32157086 details
PRS6B_HUMANTRAP1_HUMANBioGRID21979464 details
PRS6B_HUMANNR1I3_HUMANBioGRID8603043 details
PRS6B_HUMANPSMD3_HUMANBioGRID22863883 22939629 26344197 28292943 details
PRS6B_HUMANPSA6_HUMANBioGRID22939629 26344197 28292943 details
PRS6B_HUMANUBCP1_HUMANBioGRID27880917 28539385 details
PRS6B_HUMANPRS6B_HUMANBioGRID28292943 details
PRS6B_HUMANZFAN1_HUMANBioGRID29804830 details
PRS6B_HUMANUBS3A_HUMANBioGRID31659016 details
PRS6B_HUMANSUMO2_HUMANBioGRID32786267 details
PRS6B_HUMANOGT1_HUMANBioGRID32994395 details
PRS6B_HUMANPSMD6_HUMANBioGRID, IntAct17353931 22275368 22863883 22939629 26344197 details
PRS6B_HUMANKT33B_HUMANIntAct17353931 details
PRS6B_HUMANTRIP6_HUMANIntAct17353931 details
PRS6B_HUMANEPB41_HUMANIntAct17353931 details
PRS6B_HUMANPSMD1_HUMANBioGRID, IntAct17353931 22275368 22863883 22939629 26344197 28514442 28598414 32157086 details
PRS6B_HUMANPSMD2_HUMANBioGRID, IntAct17353931 22275368 22863883 22939629 26344197 28514442 32631902 details
PRS6B_HUMANIKKE_HUMANIntAct17353931 details
PRS6B_HUMANTRAF6_HUMANIntAct17353931 details
PRS6B_HUMANAAKB1_HUMANIntAct17353931 details
PRS6B_HUMANPAAF1_HUMANBioGRID, HPRD, IntAct15831487 17353931 28514442 details
PRS6B_HUMANPSMD4_HUMANBioGRID, DIP, MINT16990800 22863883 22939629 26344197 30479383 32157086 32631902 details
PRS6B_HUMANADRM1_HUMANBioGRID, IntAct, MINT22863883 24811749 26186194 26344197 26466095 28514442 28598414 32631902 details
PRS6B_HUMANINTU_HUMANBioGRID, IntAct27173435 unassigned1312 details
PRS6B_HUMANSRRM2_HUMANBioGRID16159877 details
PRS6B_HUMANHDAC5_HUMANBioGRID21081666 details
PRS6B_HUMANM3K5_HUMANBioGRID20843792 details
PRS6B_HUMANRD23A_HUMANBioGRID19013454 details
PRS6B_HUMANSEM1_HUMANBioGRID15610744 details
PRS6B_HUMANSEML_HUMANBioGRID15610744 details
PRS6B_HUMANFKBP8_HUMANBioGRID17573772 details
PRS6B_HUMANPSMD8_HUMANBioGRID21628461 22275368 22863883 22939629 26344197 details
PRS6B_HUMANPSB5_HUMANBioGRID21628461 22939629 26344197 details
PRS6B_HUMANTRIM5_HUMANBioGRID22078707 details
PRS6B_HUMANSNCAP_HUMANBioGRID17327361 details
PRS6B_HUMANPFD5_HUMANBioGRID17786314 details
PRS6B_HUMANPSA2_HUMANBioGRID19193609 22939629 26344197 details
PRS6B_HUMANPRAME_HUMANBioGRID22912744 details
PRS6B_HUMANHERC3_HUMANBioGRID26476452 details
PRS6B_HUMANUBE3A_HUMANBioGRID22645313 29426014 30257870 32157086 details
PRS6B_HUMANRPN2_HUMANBioGRID32631902 details