Entity Details

Primary name PA24A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP47712
EntryNamePA24A_HUMAN
FullNameCytosolic phospholipase A2
TaxID9606
Evidenceevidence at protein level
Length749
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesPLA2G4A

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0001516 prostaglandin biosynthetic process
GO:0002827 positive regulation of T-helper 1 type immune response
GO:0004622 lysophospholipase activity
GO:0004623 phospholipase A2 activity
GO:0005509 calcium ion binding
GO:0005544 calcium-dependent phospholipid binding
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005743 mitochondrial inner membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006071 glycerol metabolic process
GO:0006640 monoacylglycerol biosynthetic process
GO:0006644 phospholipid metabolic process
GO:0006654 phosphatidic acid biosynthetic process
GO:0006663 platelet activating factor biosynthetic process
GO:0006690 icosanoid metabolic process
GO:0008374 O-acyltransferase activity
GO:0010314 phosphatidylinositol-5-phosphate binding
GO:0010572 positive regulation of platelet activation
GO:0019369 arachidonic acid metabolic process
GO:0019370 leukotriene biosynthetic process
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0032308 positive regulation of prostaglandin secretion
GO:0034478 phosphatidylglycerol catabolic process
GO:0034638 phosphatidylcholine catabolic process
GO:0035965 cardiolipin acyl-chain remodeling
GO:0036148 phosphatidylglycerol acyl-chain remodeling
GO:0036149 phosphatidylinositol acyl-chain remodeling
GO:0036150 phosphatidylserine acyl-chain remodeling
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0042127 regulation of cell population proliferation
GO:0043032 positive regulation of macrophage activation
GO:0043231 intracellular membrane-bounded organelle
GO:0046475 glycerophospholipid catabolic process
GO:0047498 calcium-dependent phospholipase A2 activity
GO:0047499 calcium-independent phospholipase A2 activity
GO:0050482 arachidonic acid secretion
GO:0070273 phosphatidylinositol-4-phosphate binding
GO:0071236 cellular response to antibiotic
GO:0102545 phosphatidyl phospholipase B activity
GO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
GO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
GO:1902387 ceramide 1-phosphate binding

Subcellular Location

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Subcellular Location
Cytoplasm
Golgi apparatus membrane
Nucleus envelope

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR002642 Lysophospholipase, catalytic domainDomainDomain
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipaseFamilyHomologous superfamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR041847 Cytosolic phospholipase A2, C2 domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00041 AldesleukinDrugbankbiotech
DB00086 StreptokinaseDrugbankbiotech
DB00411 CarbamoylcholineDrugbanksmall molecule
DB00445 EpirubicinDrugbanksmall molecule
DB00578 CarbenicillinDrugbanksmall molecule
DB00588 Fluticasone propionateDrugbanksmall molecule
DB00721 ProcaineDrugbanksmall molecule
DB01083 OrlistatDrugbanksmall molecule
DB01103 QuinacrineDrugbanksmall molecule
DB04552 Niflumic acidDrugbanksmall molecule
DB04786 SuraminDrugbanksmall molecule
DB04827 UrethaneSwissprotsmall molecule
DB05029 LancovutideSwissprotsmall molecule
DB06311 DarapladibDrugbanksmall molecule
DB13867 FluticasoneDrugbanksmall molecule

Interactions

36 interactions

InteractorPartnerSourcesPublicationsLink
PA24A_HUMANTF65_HUMANBioGRID, DIP18330356 details
PA24A_HUMANCAP1_HUMANBioGRID, DIP18330356 details
PA24A_HUMANUBXN1_HUMANBioGRID, DIP18330356 details
PA24A_HUMANBORC6_HUMANBioGRID, DIP18330356 details
PA24A_HUMANKAT5_HUMANBioGRID, HPRD11416127 26303530 details
PA24A_HUMANSHBG_HUMANBioGRID15862967 details
PA24A_HUMANXAGE1_HUMANBioGRID18330356 details
PA24A_HUMANS10AA_HUMANBioGRID12163506 14599294 18065419 details
PA24A_HUMANANXA2_HUMANBioGRID14599294 18065419 details
PA24A_HUMANMK01_HUMANBioGRID21185392 9468497 details
PA24A_HUMANKPCA_HUMANBioGRID16963226 details
PA24A_HUMANITB3_HUMANBioGRID18840708 details
PA24A_HUMANITA2B_HUMANBioGRID18840708 details
PA24A_HUMANNCF1_HUMANBioGRID16844764 18765662 details
PA24A_HUMANNCF2_HUMANBioGRID16844764 18765662 details
PA24A_HUMANSIR2_HUMANBioGRID26303530 details
PA24A_HUMANELF3_HUMANIntAct17353931 details
PA24A_HUMANJAK1_HUMANBioGRID, HPRD8612580 details
PA24A_HUMANEHD1_HUMANBioGRID22456504 details
PA24A_HUMANMK03_HUMANBioGRID21185392 details
PA24A_HUMANLOX12_HUMANBioGRID15474031 details
PA24A_HUMANMYBB_HUMANBioGRID14769798 details
PA24A_HUMANVIME_HUMANBioGRID, HPRD10625659 18840708 details
PA24A_HUMANANXA1_HUMANBioGRID17873281 17932043 details
PA24A_HUMANS10AB_HUMANBioGRID17932043 details
PA24A_HUMANCDK2_HUMANBioGRID26303530 details
PA24A_HUMANCCNA2_HUMANBioGRID26303530 details
PA24A_HUMANCASP3_HUMANHPRD9875225 details
PA24A_HUMANPA2G5_HUMANHPRD12124392 details
PA24A_HUMANKS6A5_HUMANHPRD10978317 details
PA24A_HUMANPA24A_HUMANHPRD9430701 details
PA24A_HUMANMAPK5_HUMANHPRD10978317 8636128 9468497 details
PA24A_HUMANMKNK1_HUMANHPRD10978317 8636128 9468497 details
PA24A_HUMANCASP4_HUMANHPRD9875225 details
PA24A_HUMANMK14_HUMANHPRD9468497 details
PA24A_HUMANCASP1_HUMANHPRD9875225 details