Entity Details

Primary name NRAM2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49281
EntryNameNRAM2_HUMAN
FullNameNatural resistance-associated macrophage protein 2
TaxID9606
Evidenceevidence at protein level
Length568
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesSLC11A2

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0003032 detection of oxygen
GO:0005375 copper ion transmembrane transporter activity
GO:0005381 iron ion transmembrane transporter activity
GO:0005384 manganese ion transmembrane transporter activity
GO:0005385 zinc ion transmembrane transporter activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005773 vacuole
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006783 heme biosynthetic process
GO:0006824 cobalt ion transport
GO:0006825 copper ion transport
GO:0006826 iron ion transport
GO:0006828 manganese ion transport
GO:0006879 cellular iron ion homeostasis
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007611 learning or memory
GO:0009986 cell surface
GO:0010039 response to iron ion
GO:0015086 cadmium ion transmembrane transporter activity
GO:0015087 cobalt ion transmembrane transporter activity
GO:0015093 ferrous iron transmembrane transporter activity
GO:0015094 lead ion transmembrane transporter activity
GO:0015099 nickel cation transmembrane transporter activity
GO:0015100 vanadium ion transmembrane transporter activity
GO:0015295 solute:proton symporter activity
GO:0015675 nickel cation transport
GO:0015676 vanadium ion transport
GO:0015692 lead ion transport
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0022890 inorganic cation transmembrane transporter activity
GO:0031410 cytoplasmic vesicle
GO:0031526 brush border membrane
GO:0031902 late endosome membrane
GO:0033212 iron import into cell
GO:0034599 cellular response to oxidative stress
GO:0034755 iron ion transmembrane transport
GO:0045177 apical part of cell
GO:0045178 basal part of cell
GO:0046870 cadmium ion binding
GO:0046915 transition metal ion transmembrane transporter activity
GO:0048471 perinuclear region of cytoplasm
GO:0048813 dendrite morphogenesis
GO:0048821 erythrocyte development
GO:0055037 recycling endosome
GO:0060586 multicellular organismal iron ion homeostasis
GO:0070574 cadmium ion transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0070826 paraferritin complex
GO:0071577 zinc ion transmembrane transport
GO:0098656 anion transmembrane transport
GO:1903561 extracellular vesicle
GO:1905394 retromer complex binding

Subcellular Location

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Subcellular Location
Cell membrane
Early endosome
Endosome membrane
Mitochondrion outer membrane

Domains

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DomainNameCategoryType
IPR001046 NRAMP familyFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB06796 MangafodipirSwissprotsmall molecule
DB09130 CopperDrugbanksmall molecule
DB13257 Ferrous sulfate anhydrousDrugbanksmall molecule
DB14520 Tetraferric tricitrate decahydrateDrugbanksmall molecule
DB15598 Ferric maltolDrugbanksmall molecule