Entity Details

Primary name FNTA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49354
EntryNameFNTA_HUMAN
FullNameProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
TaxID9606
Evidenceevidence at protein level
Length379
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesFNTA

GO terms

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GOName
GO:0000165 MAPK cascade
GO:0004660 protein farnesyltransferase activity
GO:0004661 protein geranylgeranyltransferase activity
GO:0004662 CAAX-protein geranylgeranyltransferase activity
GO:0004663 Rab geranylgeranyltransferase activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005875 microtubule associated complex
GO:0005886 plasma membrane
GO:0005953 CAAX-protein geranylgeranyltransferase complex
GO:0005965 protein farnesyltransferase complex
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0008017 microtubule binding
GO:0018343 protein farnesylation
GO:0018344 protein geranylgeranylation
GO:0022400 regulation of rhodopsin mediated signaling pathway
GO:0030548 acetylcholine receptor regulator activity
GO:0030971 receptor tyrosine kinase binding
GO:0043014 alpha-tubulin binding
GO:0045213 neurotransmitter receptor metabolic process
GO:0071340 skeletal muscle acetylcholine-gated channel clustering
GO:0090044 positive regulation of tubulin deacetylation
GO:0090045 positive regulation of deacetylase activity

Subcellular Location

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Domains

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DomainNameCategoryType
IPR002088 Protein prenyltransferase, alpha subunitRepeatRepeat

Diseases

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Drugs

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DrugNameSourceType
DB04893 AZD3409Drugbanksmall molecule
DB06448 LonafarnibDrugbanksmall molecule
DB06953 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILEDrugbanksmall molecule
DB07216 (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINEDrugbanksmall molecule
DB07227 L-778123Drugbanksmall molecule
DB07771 [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACIDDrugbanksmall molecule
DB07780 Farnesyl diphosphateDrugbanksmall molecule
DB07841 Geranylgeranyl diphosphateDrugbanksmall molecule
DB07895 ALPHA-HYDROXYFARNESYLPHOSPHONIC ACIDDrugbanksmall molecule
DB08180 2-[METHYL-(5-GERANYL-4-METHYL-PENT-3-ENYL)-AMINO]-ETHYL-DIPHOSPHATEDrugbanksmall molecule
DB08674 (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILEDrugbanksmall molecule
DB08676 (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILEDrugbanksmall molecule