Entity Details

Primary name SYSC_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP49591
EntryNameSYSC_HUMAN
FullNameSerine--tRNA ligase, cytoplasmic
TaxID9606
Evidenceevidence at protein level
Length514
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesSARS1

GO terms

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GOName
GO:0000049 tRNA binding
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003723 RNA binding
GO:0004828 serine-tRNA ligase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006434 seryl-tRNA aminoacylation
GO:0008033 tRNA processing
GO:0016259 selenocysteine metabolic process
GO:0016525 negative regulation of angiogenesis
GO:0019899 enzyme binding
GO:0042803 protein homodimerization activity
GO:0070062 extracellular exosome
GO:0097056 selenocysteinyl-tRNA(Sec) biosynthetic process
GO:1904046 negative regulation of vascular endothelial growth factor production

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR002314 Aminoacyl-tRNA synthetase, class II (G/ P/ S/T)DomainDomain
IPR002317 Serine-tRNA ligase, type1FamilyFamily
IPR006195 Aminoacyl-tRNA synthetase, class IIDomainDomain
IPR010978 Class I and II aminoacyl-tRNA synthetase, tRNA-binding armFamilyHomologous superfamily
IPR015866 Serine-tRNA synthetase, type1, N-terminalDomainDomain
IPR033729 Serine-tRNA ligase catalytic core domainDomainDomain
IPR042103 Serine-tRNA synthetase, type1, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
617709 OMIMNeurodevelopmental disorder with microcephaly, ataxia, and seizures (NEDMAS)An autosomal recessive disorder characterized by delayed psychomotor development, intellectual disability, seizures apparent in infancy, impaired speech, and aggressive behavior. Additional features include microcephaly, ataxia, and muscle weakness. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00133 SerineDrugbanksmall molecule