Entity Details

Primary name P2RX1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51575
EntryNameP2RX1_HUMAN
FullNameP2X purinoceptor 1
TaxID9606
Evidenceevidence at protein level
Length399
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesP2RX1

GO terms

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GOName
GO:0001614 purinergic nucleotide receptor activity
GO:0002554 serotonin secretion by platelet
GO:0003056 regulation of vascular associated smooth muscle contraction
GO:0004931 extracellularly ATP-gated cation channel activity
GO:0005261 cation channel activity
GO:0005524 ATP binding
GO:0005639 integral component of nuclear inner membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006811 ion transport
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 signal transduction
GO:0007320 insemination
GO:0007596 blood coagulation
GO:0008217 regulation of blood pressure
GO:0009897 external side of plasma membrane
GO:0019228 neuronal action potential
GO:0030168 platelet activation
GO:0030667 secretory granule membrane
GO:0032991 protein-containing complex
GO:0033198 response to ATP
GO:0035249 synaptic transmission, glutamatergic
GO:0035579 specific granule membrane
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043312 neutrophil degranulation
GO:0044877 protein-containing complex binding
GO:0045121 membrane raft
GO:0046513 ceramide biosynthetic process
GO:0098978 glutamatergic synapse
GO:0099055 integral component of postsynaptic membrane
GO:0099059 integral component of presynaptic active zone membrane
GO:0099509 regulation of presynaptic cytosolic calcium ion concentration
GO:1905665 positive regulation of calcium ion import across plasma membrane
GO:2000300 regulation of synaptic vesicle exocytosis

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR001429 P2X purinoreceptorFamilyFamily
IPR003044 P2X1 purinoceptorFamilyFamily
IPR027309 P2X purinoreceptor extracellular domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01069 PromethazineDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
P2RX1_HUMANCYBC1_HUMANBioGRID, IntAct32296183 details
P2RX1_HUMANP2RX2_HUMANHPRD15313628 details