Entity Details

Primary name NEK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP51955
EntryNameNEK2_HUMAN
FullNameSerine/threonine-protein kinase Nek2
TaxID9606
Evidenceevidence at protein level
Length445
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesNEK2

GO terms

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GOName
GO:0000070 mitotic sister chromatid segregation
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0000776 kinetochore
GO:0000794 condensed nuclear chromosome
GO:0000922 spindle pole
GO:0001824 blastocyst development
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005874 microtubule
GO:0006468 protein phosphorylation
GO:0007059 chromosome segregation
GO:0007088 regulation of mitotic nuclear division
GO:0007096 regulation of exit from mitosis
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0019903 protein phosphatase binding
GO:0030496 midbody
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0032991 protein-containing complex
GO:0043392 negative regulation of DNA binding
GO:0046602 regulation of mitotic centrosome separation
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0051225 spindle assembly
GO:0051299 centrosome separation
GO:0051301 cell division
GO:0051321 meiotic cell cycle
GO:0051973 positive regulation of telomerase activity
GO:0051988 regulation of attachment of spindle microtubules to kinetochore
GO:0090307 mitotic spindle assembly
GO:0097711 ciliary basal body-plasma membrane docking
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903126 negative regulation of centriole-centriole cohesion
GO:1904355 positive regulation of telomere capping

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615565 OMIMRetinitis pigmentosa 67 (RP67)A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB07180 5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N,2,4-trimethyl-1H-pyrrole-3-carboxamideDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
NEK2_HUMANNEK11_HUMANHPRD, IntAct15161910 details
NEK2_HUMANRHOB_HUMANIntAct19637314 details
NEK2_HUMANPP1G_HUMANBioGRID, IntAct21382349 23080069 24116158 24902662 details
NEK2_HUMANEDRF1_HUMANBioGRID, MINT21900206 details
NEK2_HUMANCC85A_HUMANBioGRID, MINT21900206 details
NEK2_HUMANCMGA_HUMANBioGRID, MINT21900206 details
NEK2_HUMANDCTN1_HUMANBioGRID, MINT21900206 details
NEK2_HUMANIF4A2_HUMANBioGRID, MINT21900206 details
NEK2_HUMANGIT1_HUMANBioGRID, MINT21900206 details
NEK2_HUMANIF140_HUMANBioGRID, MINT21900206 details
NEK2_HUMANMIC60_HUMANBioGRID, MINT21900206 details
NEK2_HUMANCRCM_HUMANBioGRID, MINT21900206 details
NEK2_HUMANNDC80_HUMANBioGRID, HPRD, MINT12386167 21900206 9295362 details
NEK2_HUMANMYOME_HUMANBioGRID, MINT21900206 details
NEK2_HUMANSPTN4_HUMANBioGRID, MINT21900206 details
NEK2_HUMANTCF25_HUMANBioGRID, MINT21900206 details
NEK2_HUMANTPM3_HUMANBioGRID, MINT21900206 details
NEK2_HUMANPP1A_HUMANBioGRID, HPRD, IntAct10880350 12221103 22321011 details
NEK2_HUMANNEK2_HUMANBioGRID, HPRD, MINT10347187 23288039 details
NEK2_HUMANKIF24_HUMANUniProt26290419 details
NEK2_HUMANPTPRD_HUMANBioGRID, MINT22305495 details
NEK2_HUMANMK01_HUMANBioGRID, HPRD15358203 details
NEK2_HUMANCP250_HUMANBioGRID, HPRD23443559 9647649 details
NEK2_HUMANCLC4C_HUMANBioGRID12386167 details
NEK2_HUMANIPP2_HUMANBioGRID, HPRD12221103 details
NEK2_HUMANCASB_HUMANBioGRID15147269 details
NEK2_HUMANCDC20_HUMANBioGRID23160376 25306918 25673878 32307883 details
NEK2_HUMANCTNB1_HUMANBioGRID24501426 details
NEK2_HUMANFZR1_HUMANBioGRID23160376 25673878 26387737 details
NEK2_HUMANPRKN_HUMANBioGRID26387737 details
NEK2_HUMANSMUF1_HUMANBioGRID20804422 details
NEK2_HUMANFANCA_HUMANBioGRID23806870 details
NEK2_HUMANMD1L1_HUMANHPRD14978040 details
NEK2_HUMANCDC27_HUMANBioGRID, IntAct16648845 25673878 29863498 32076268 details
NEK2_HUMANRITA1_HUMANMINT21102556 details
NEK2_HUMANAPC4_HUMANBioGRID, MINT23288039 25673878 25750436 29863498 details
NEK2_HUMANCHK1_HUMANBioGRID15311285 details
NEK2_HUMANMD2L1_HUMANBioGRID25673878 details
NEK2_HUMANBUB1B_HUMANBioGRID25673878 details
NEK2_HUMANUBP7_HUMANBioGRID29863498 details
NEK2_HUMANANC2_HUMANBioGRID29863498 32307883 details
NEK2_HUMANBECN1_HUMANBioGRID31955515 details