Entity Details

Primary name MSH6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP52701
EntryNameMSH6_HUMAN
FullNameDNA mismatch repair protein Msh6
TaxID9606
Evidenceevidence at protein level
Length1360
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesMSH6

GO terms

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GOName
GO:0000710 meiotic mismatch repair
GO:0000785 chromatin
GO:0003682 chromatin binding
GO:0003684 damaged DNA binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006281 DNA repair
GO:0006290 pyrimidine dimer repair
GO:0006298 mismatch repair
GO:0008094 ATPase, acting on DNA
GO:0008340 determination of adult lifespan
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009411 response to UV
GO:0016032 viral process
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0016447 somatic recombination of immunoglobulin gene segments
GO:0019899 enzyme binding
GO:0030983 mismatched DNA binding
GO:0032137 guanine/thymine mispair binding
GO:0032300 mismatch repair complex
GO:0032301 MutSalpha complex
GO:0035064 methylated histone binding
GO:0036297 interstrand cross-link repair
GO:0043231 intracellular membrane-bounded organelle
GO:0045190 isotype switching
GO:0045910 negative regulation of DNA recombination
GO:0051096 positive regulation of helicase activity
GO:0097193 intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR000313 PWWP domainDomainDomain
IPR000432 DNA mismatch repair protein MutS, C-terminalDomainDomain
IPR007695 DNA mismatch repair protein MutS-like, N-terminalDomainDomain
IPR007696 DNA mismatch repair protein MutS, coreDomainDomain
IPR007860 DNA mismatch repair protein MutS, connector domainDomainDomain
IPR007861 DNA mismatch repair protein MutS, clampDomainDomain
IPR016151 DNA mismatch repair protein MutS, N-terminalFamilyHomologous superfamily
IPR017261 DNA mismatch repair protein MutS/MSHFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036187 DNA mismatch repair protein MutS, core domain superfamilyFamilyHomologous superfamily
IPR036678 MutS, connector domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

52 interactions

InteractorPartnerSourcesPublicationsLink
MSH6_HUMANMSH2_HUMANBioGRID, DIP, HPRD, IntAct10029069 10748159 10783165 10856833 14657349 15064730 19377479 22939629 25241761 26344197 26496610 8942985 9428522 9774676 details
MSH6_HUMANCSK21_HUMANBioGRID, IntAct22113938 details
MSH6_HUMANRASH_HUMANBioGRID, MINT24412244 details
MSH6_HUMANMP2K1_HUMANBioGRID, MINT24412244 details
MSH6_HUMANSIAS_HUMANBioGRID, MINT24412244 details
MSH6_HUMANPCNA_HUMANBioGRID, HPRD, IntAct11005803 11274057 12171929 15225546 21725088 22232658 22939629 24958773 26344197 26496610 details
MSH6_HUMANH31_HUMANBioGRID, IntAct26912663 29568061 details
MSH6_HUMANBRCA1_HUMANBioGRID10783165 11498787 25184681 details
MSH6_HUMANBARD1_HUMANBioGRID11498787 16391231 details
MSH6_HUMANSMC1A_HUMANBioGRID14657349 details
MSH6_HUMANCAF1A_HUMANBioGRID22232658 details
MSH6_HUMANXRCC6_HUMANBioGRID21075794 22863883 30585729 details
MSH6_HUMANHUS1_HUMANBioGRID20188637 details
MSH6_HUMANRAD1_HUMANBioGRID20188637 details
MSH6_HUMANRAD9A_HUMANBioGRID20188637 details
MSH6_HUMANMUTYH_HUMANBioGRID, HPRD11801590 details
MSH6_HUMANPTEN_HUMANBioGRID31685992 details
MSH6_HUMANSUMO2_HUMANBioGRID32786267 details
MSH6_HUMANCRCM_HUMANIntAct17353931 details
MSH6_HUMANPSMD4_HUMANMINT16990800 details
MSH6_HUMANBLM_HUMANBioGRID10783165 15064730 details
MSH6_HUMANATM_HUMANBioGRID10783165 details
MSH6_HUMANMLH1_HUMANBioGRID10748159 10783165 12799449 30770470 details
MSH6_HUMANMRE11_HUMANBioGRID10783165 details
MSH6_HUMANNBN_HUMANBioGRID10783165 details
MSH6_HUMANRAD50_HUMANBioGRID10783165 details
MSH6_HUMANRFC1_HUMANBioGRID10783165 details
MSH6_HUMANPMS2_HUMANBioGRID10748159 12799449 17148452 details
MSH6_HUMANAIRE_HUMANBioGRID20085707 details
MSH6_HUMANATR_HUMANBioGRID20029092 details
MSH6_HUMANTOPB1_HUMANBioGRID20029092 details
MSH6_HUMANCLSPN_HUMANBioGRID20029092 details
MSH6_HUMANCHK1_HUMANBioGRID20029092 details
MSH6_HUMANKPCZ_HUMANBioGRID15808853 details
MSH6_HUMANMO4L1_HUMANBioGRID19553677 details
MSH6_HUMANEP300_HUMANBioGRID, HPRD16051665 details
MSH6_HUMANCBP_HUMANBioGRID, HPRD16051665 details
MSH6_HUMANDTL_HUMANBioGRID21725088 details
MSH6_HUMANSMRCD_HUMANBioGRID21549307 details
MSH6_HUMANPMS1_HUMANBioGRID10748159 details
MSH6_HUMANP53_HUMANBioGRID15064730 details
MSH6_HUMANRAD51_HUMANBioGRID15064730 details
MSH6_HUMANXRCC5_HUMANBioGRID21075794 details
MSH6_HUMANPRKDC_HUMANBioGRID21075794 details
MSH6_HUMANSLX4_HUMANBioGRID22902628 31495888 details
MSH6_HUMANSIR6_HUMANBioGRID24169447 details
MSH6_HUMANRN126_HUMANBioGRID26508657 details
MSH6_HUMANNUCL_HUMANBioGRID27049334 details
MSH6_HUMANHDAC6_HUMANBioGRID24882211 details
MSH6_HUMANMCM9_HUMANBioGRID26300262 26870752 details
MSH6_HUMANH2AX_HUMANBioGRID26095369 28242625 details
MSH6_HUMANTRI29_HUMANBioGRID26095369 details