Entity Details

Primary name NKX25_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP52952
EntryNameNKX25_HUMAN
FullNameHomeobox protein Nkx-2.5
TaxID9606
Evidenceevidence at protein level
Length324
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesNKX2-5

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001216 DNA-binding transcription activator activity
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001570 vasculogenesis
GO:0001947 heart looping
GO:0003007 heart morphogenesis
GO:0003148 outflow tract septum morphogenesis
GO:0003161 cardiac conduction system development
GO:0003180 aortic valve morphogenesis
GO:0003221 right ventricular cardiac muscle tissue morphogenesis
GO:0003228 atrial cardiac muscle tissue development
GO:0003285 septum secundum development
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005667 transcription regulator complex
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007512 adult heart development
GO:0008134 transcription factor binding
GO:0008284 positive regulation of cell population proliferation
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010735 positive regulation of transcription via serum response element binding
GO:0010765 positive regulation of sodium ion transport
GO:0010832 negative regulation of myotube differentiation
GO:0030097 hemopoiesis
GO:0030154 cell differentiation
GO:0030878 thyroid gland development
GO:0032991 protein-containing complex
GO:0032993 protein-DNA complex
GO:0035050 embryonic heart tube development
GO:0043066 negative regulation of apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045666 positive regulation of neuron differentiation
GO:0045823 positive regulation of heart contraction
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048536 spleen development
GO:0051891 positive regulation of cardioblast differentiation
GO:0055007 cardiac muscle cell differentiation
GO:0055008 cardiac muscle tissue morphogenesis
GO:0055013 cardiac muscle cell development
GO:0055014 atrial cardiac muscle cell development
GO:0055015 ventricular cardiac muscle cell development
GO:0055117 regulation of cardiac muscle contraction
GO:0060037 pharyngeal system development
GO:0060048 cardiac muscle contraction
GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter
GO:0060412 ventricular septum morphogenesis
GO:0060413 atrial septum morphogenesis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090575 RNA polymerase II transcription regulator complex
GO:1903779 regulation of cardiac conduction
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site
IPR020479 Homeobox domain, metazoaDomainDomain
IPR033629 Homeobox protein NKX-2.5FamilyFamily

Diseases

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