Entity Details

Primary name BLM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP54132
EntryNameBLM_HUMAN
FullNameBloom syndrome protein
TaxID9606
Evidenceevidence at protein level
Length1417
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesBLM

GO terms

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GOName
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000228 nuclear chromosome
GO:0000400 four-way junction DNA binding
GO:0000403 Y-form DNA binding
GO:0000405 bubble DNA binding
GO:0000723 telomere maintenance
GO:0000724 double-strand break repair via homologous recombination
GO:0000729 DNA double-strand break processing
GO:0000800 lateral element
GO:0002039 p53 binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006260 DNA replication
GO:0006268 DNA unwinding involved in DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006974 cellular response to DNA damage stimulus
GO:0007095 mitotic G2 DNA damage checkpoint signaling
GO:0008094 ATPase, acting on DNA
GO:0008270 zinc ion binding
GO:0009378 four-way junction helicase activity
GO:0010165 response to X-ray
GO:0016363 nuclear matrix
GO:0016605 PML body
GO:0016887 ATP hydrolysis activity
GO:0031297 replication fork processing
GO:0032201 telomere maintenance via semi-conservative replication
GO:0032508 DNA duplex unwinding
GO:0032991 protein-containing complex
GO:0036310 ATP-dependent DNA/DNA annealing activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043138 3'-5' DNA helicase activity
GO:0044806 G-quadruplex DNA unwinding
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045910 negative regulation of DNA recombination
GO:0048478 replication fork protection
GO:0051259 protein complex oligomerization
GO:0051260 protein homooligomerization
GO:0051782 negative regulation of cell division
GO:0051880 G-quadruplex DNA binding
GO:0061749 forked DNA-dependent helicase activity
GO:0061820 telomeric D-loop disassembly
GO:0061821 telomeric D-loop binding
GO:0061849 telomeric G-quadruplex DNA binding
GO:0071479 cellular response to ionizing radiation
GO:0072711 cellular response to hydroxyurea
GO:0072757 cellular response to camptothecin
GO:0090329 regulation of DNA-dependent DNA replication
GO:0090656 t-circle formation
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1905773 8-hydroxy-2'-deoxyguanosine DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001650 Helicase, C-terminalDomainDomain
IPR002121 HRDC domainDomainDomain
IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved siteSiteConserved site
IPR004589 DNA helicase, ATP-dependent, RecQ typeFamilyFamily
IPR010997 HRDC-like superfamilyFamilyHomologous superfamily
IPR011545 DEAD/DEAH box helicase domainDomainDomain
IPR012532 BDHCTDomainDomain
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR018982 RQC domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR032284 ATP-dependent DNA helicase RecQ, zinc-binding domainDomainDomain
IPR032437 Bloom syndrome protein, N-terminal domainDomainDomain
IPR032439 Bloom syndrome protein, BDHCT-box associated domainDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

85 interactions

InteractorPartnerSourcesPublicationsLink
BLM_HUMANTOP3A_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10734115 10825162 11406610 11470874 12724401 15775963 20360068 20711169 23509288 24239288 26496610 30279242 details
BLM_HUMANRFA1_HUMANBioGRID, HPRD, IntAct, MINT, UniProt10825162 11950880 12181313 12724401 15775963 15965237 24126761 24239288 24332808 25135477 26474068 30279242 details
BLM_HUMANTERF2_HUMANBioGRID, HPRD, IntAct12181313 15229185 19329795 details
BLM_HUMANWRN_HUMANBioGRID, HPRD, IntAct11919194 details
BLM_HUMANFEN1_HUMANBioGRID, HPRD, IntAct14688284 16326861 details
BLM_HUMANTERF1_HUMANBioGRID, HPRD, IntAct15229185 details
BLM_HUMANFANCJ_HUMANBioGRID, MINT21240188 24895130 details
BLM_HUMANP53_HUMANBioGRID, HPRD, MINT11399766 11781842 12080066 12606585 15364958 15806145 22653443 24239288 32807901 details
BLM_HUMANRA51D_HUMANBioGRID, HPRD, UniProt12975363 details
BLM_HUMANXRCC2_HUMANBioGRID, UniProt12975363 details
BLM_HUMANRS27_HUMANDIP16864798 details
BLM_HUMANRAD51_HUMANBioGRID, DIP, HPRD11278509 11309417 12606585 15064730 17984114 18562274 19671661 19956565 29523790 details
BLM_HUMANEXO1_HUMANBioGRID, DIP18971343 24705021 31153714 details
BLM_HUMANTP53B_HUMANBioGRID, HPRD, UniProt15364958 17984114 29656893 details
BLM_HUMANSPIDR_HUMANBioGRID, UniProt23509288 details
BLM_HUMANATM_HUMANBioGRID10783165 12034743 29523790 details
BLM_HUMANMLH1_HUMANBioGRID, HPRD10783165 11325959 11470874 11691925 12724401 19015241 21466675 details
BLM_HUMANNBN_HUMANBioGRID10783165 29523790 details
BLM_HUMANCASP3_HUMANBioGRID, HPRD11470874 details
BLM_HUMANCAF1A_HUMANBioGRID, HPRD15143166 details
BLM_HUMANMX1_HUMANBioGRID, HPRD11716541 details
BLM_HUMANUBC9_HUMANBioGRID15829507 details
BLM_HUMANSYN1_HUMANBioGRID15829507 details
BLM_HUMANMCRS1_HUMANBioGRID15829507 details
BLM_HUMANPSMD3_HUMANBioGRID15829507 details
BLM_HUMANATR_HUMANBioGRID14729972 details
BLM_HUMANATRX_HUMANBioGRID19671661 details
BLM_HUMANRNF8_HUMANBioGRID23708797 29523790 details
BLM_HUMANTRI49_HUMANBioGRID23708797 details
BLM_HUMANSUMO1_HUMANBioGRID16524884 details
BLM_HUMANSUMO2_HUMANBioGRID, HPRD16524884 16620772 details
BLM_HUMANRENT2_HUMANBioGRID15231747 details
BLM_HUMANTOPB1_HUMANBioGRID24239288 30295604 details
BLM_HUMANMIB1_HUMANBioGRID24239288 30044990 details
BLM_HUMANNEK11_HUMANBioGRID24239288 details
BLM_HUMANMYC_HUMANBioGRID23750012 29467282 30415952 details
BLM_HUMANJUN_HUMANBioGRID23750012 30044990 details
BLM_HUMANFBXW7_HUMANBioGRID23750012 30044990 details
BLM_HUMANDNA2_HUMANBioGRID31153714 details
BLM_HUMANRMI1_HUMANBioGRID, DIP, IntAct, MINT, UniProt15775963 20064461 20360068 20711169 20826342 23509288 24239288 26496610 details
BLM_HUMANRFA3_HUMANBioGRID, MINT, UniProt12724401 15775963 24126761 24332808 30279242 details
BLM_HUMANRFA2_HUMANBioGRID, IntAct, MINT, UniProt12724401 15775963 24126761 24332808 28506294 30279242 details
BLM_HUMANRIF1_HUMANBioGRID, MINT, UniProt20711169 23509288 details
BLM_HUMANRMI2_HUMANBioGRID, DIP, IntAct, MINT, UniProt20711169 20826341 20826342 23509288 26186194 28514442 30279242 details
BLM_HUMANUIMC1_HUMANBioGRID, MINT23708797 details
BLM_HUMANAIPL1_HUMANBioGRID, IntAct27173435 unassigned1312 details
BLM_HUMANNEK4_HUMANBioGRID, IntAct27173435 unassigned1312 details
BLM_HUMANPDE5A_HUMANBioGRID, IntAct27173435 unassigned1312 details
BLM_HUMANMIO_HUMANBioGRID, IntAct27173435 unassigned1312 details
BLM_HUMANCEP43_HUMANBioGRID, IntAct27173435 unassigned1312 details
BLM_HUMANPLK1_HUMANDIP16864798 details
BLM_HUMANBRCA1_HUMANBioGRID, UniProt10783165 25084169 26831064 29656893 details
BLM_HUMANSOSB1_HUMANIntAct28506294 details
BLM_HUMANMRE11_HUMANBioGRID, IntAct10783165 28506294 29523790 details
BLM_HUMANFANCA_HUMANBioGRID, UniProt12724401 12973351 22343915 22705371 23509288 details
BLM_HUMANFANCM_HUMANBioGRID, UniProt16116422 20064461 20347428 23509288 24699063 details
BLM_HUMANFACD2_HUMANBioGRID, HPRD15257300 25135477 31180492 details
BLM_HUMANH2AX_HUMANBioGRID15364958 29523790 details
BLM_HUMANMSH2_HUMANBioGRID10783165 15064730 details
BLM_HUMANMSH6_HUMANBioGRID10783165 15064730 details
BLM_HUMANRAD50_HUMANBioGRID10783165 25084169 29523790 details
BLM_HUMANCHK1_HUMANBioGRID, HPRD15364958 details
BLM_HUMANRFC1_HUMANBioGRID10783165 details
BLM_HUMANCENPS_HUMANBioGRID20347428 20347429 24699063 details
BLM_HUMANPAXI1_HUMANBioGRID17500065 details
BLM_HUMANFANCG_HUMANBioGRID12724401 details
BLM_HUMANTEP1_HUMANBioGRID19329795 details
BLM_HUMANBLM_HUMANBioGRID19329795 24239288 details
BLM_HUMANHS90A_HUMANBioGRID19329795 details
BLM_HUMANTOP2A_HUMANBioGRID19329795 details
BLM_HUMANSF3B2_HUMANBioGRID19329795 details
BLM_HUMANPARP1_HUMANBioGRID24239288 34079125 details
BLM_HUMANPWP1_HUMANBioGRID24239288 details
BLM_HUMANCENPX_HUMANBioGRID20347428 details
BLM_HUMANFAN1_HUMANBioGRID25135477 details
BLM_HUMANAPBB1_HUMANBioGRID23572515 details
BLM_HUMANPHF8_HUMANBioGRID27183383 details
BLM_HUMANHERC2_HUMANBioGRID30279242 details
BLM_HUMANXRCC4_HUMANBioGRID29523790 details
BLM_HUMANETAA1_HUMANBioGRID27723720 details
BLM_HUMANDYL1_HUMANBioGRID30464262 details
BLM_HUMANMCE1_HUMANBioGRID29395067 details
BLM_HUMANECT2_HUMANBioGRID32929379 details
BLM_HUMANSUMO3_HUMANHPRD16620772 details
BLM_HUMANSMC1A_HUMANHPRD11877377 details