Entity Details

Primary name AFAD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP55196
EntryNameAFAD_HUMAN
FullNameAfadin
TaxID9606
Evidenceevidence at protein level
Length1824
SequenceStatuscomplete
DateCreated1996-10-01
DateModified2021-06-02

Ontological Relatives

GenesAFDN

GO terms

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GOName
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008022 protein C-terminus binding
GO:0010628 positive regulation of gene expression
GO:0016607 nuclear speck
GO:0022409 positive regulation of cell-cell adhesion
GO:0030054 cell junction
GO:0030336 negative regulation of cell migration
GO:0031267 small GTPase binding
GO:0032880 regulation of protein localization
GO:0034332 adherens junction organization
GO:0043547 positive regulation of GTPase activity
GO:0044291 cell-cell contact zone
GO:0044331 cell-cell adhesion mediated by cadherin
GO:0045296 cadherin binding
GO:0046930 pore complex
GO:0046931 pore complex assembly
GO:0050839 cell adhesion molecule binding
GO:0051015 actin filament binding
GO:0061951 establishment of protein localization to plasma membrane
GO:0070160 tight junction
GO:0070830 bicellular tight junction assembly
GO:0090557 establishment of endothelial intestinal barrier
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin

Subcellular Location

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Subcellular Location
Cell junction

Domains

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DomainNameCategoryType
IPR000159 Ras-associating (RA) domainDomainDomain
IPR000253 Forkhead-associated (FHA) domainDomainDomain
IPR001478 PDZ domainDomainDomain
IPR002710 Dilute domainDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily
IPR037977 Afadin, cargo binding domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB08574 (5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-oneDrugbanksmall molecule

Interactions

74 interactions

InteractorPartnerSourcesPublicationsLink
AFAD_HUMANRASM_HUMANMINT10446149 details
AFAD_HUMANRBTN2_HUMANBioGRID, MINT12067721 details
AFAD_HUMANRIT1_HUMANBioGRID, IntAct10545207 details
AFAD_HUMANNECT1_HUMANBioGRID, MINT10225955 15811349 details
AFAD_HUMANNECT2_HUMANBioGRID, IntAct, MINT10225955 10617658 15811349 23750010 34079125 details
AFAD_HUMANEPHA7_HUMANBioGRID, MINT34079125 9707552 details
AFAD_HUMANEPHB2_HUMANBioGRID, MINT9707552 details
AFAD_HUMANEPHB6_HUMANBioGRID, MINT9707552 details
AFAD_HUMANEPHB3_HUMANBioGRID, MINT9707552 details
AFAD_HUMANNECT3_HUMANBioGRID, MINT10744716 11024295 15811349 details
AFAD_HUMANNECT4_HUMANMINT15811349 details
AFAD_HUMANSMAD2_HUMANBioGRID, MINT15231748 details
AFAD_HUMANSRC_HUMANMINT17491594 details
AFAD_HUMANBCR_HUMANBioGRID, MINT12808105 17491594 34079125 details
AFAD_HUMANZO1_HUMANBioGRID, IntAct10334923 23750010 34079125 details
AFAD_HUMANCTNA1_HUMANBioGRID, IntAct11907041 23750010 34079125 details
AFAD_HUMANRPGP1_HUMANBioGRID12590145 details
AFAD_HUMANPROF1_HUMANBioGRID10922060 details
AFAD_HUMANADIP_HUMANBioGRID12446711 details
AFAD_HUMANUSP9X_HUMANBioGRID10620020 9722616 details
AFAD_HUMANRASH_HUMANBioGRID10334923 10922060 8557659 details
AFAD_HUMANRAP1A_HUMANBioGRID10922060 details
AFAD_HUMANNRX1B_HUMANBioGRID9707552 details
AFAD_HUMANNRX1A_HUMANBioGRID9707552 details
AFAD_HUMANNRX2B_HUMANBioGRID9707552 details
AFAD_HUMANNRX2A_HUMANBioGRID9707552 details
AFAD_HUMANNRX3B_HUMANBioGRID9707552 details
AFAD_HUMANNRX3A_HUMANBioGRID9707552 details
AFAD_HUMANJAG1_HUMANBioGRID9707552 details
AFAD_HUMANSRBS1_HUMANBioGRID10085297 34079125 details
AFAD_HUMANRIN1_HUMANBioGRID10545207 details
AFAD_HUMANSRBS2_HUMANBioGRID10521485 details
AFAD_HUMANJAM1_HUMANBioGRID10856295 details
AFAD_HUMANRRAS2_HUMANBioGRID11788587 details
AFAD_HUMANPRKN_HUMANBioGRID23393160 details
AFAD_HUMAN1433Z_HUMANMINT15161933 details
AFAD_HUMANDREB_HUMANIntAct23750010 details
AFAD_HUMANDCLK1_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANSI1L1_HUMANBioGRID, IntAct27173435 34079125 unassigned1312 details
AFAD_HUMANGGYF1_HUMANIntActunassigned1312 details
AFAD_HUMANRAB3I_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANDEN1A_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANKSR1_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANAN34A_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANSPD2A_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANTBC25_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANZN638_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANCDK16_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANMPIP2_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANSRGP2_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANIF4E2_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANFA53C_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANKCTD3_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANAGAP1_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANZBT21_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANUBP21_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANLIMA1_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANSYDE1_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANF110B_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANSRS12_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANMAGI1_HUMANBioGRID, IntAct27173435 34079125 unassigned1312 details
AFAD_HUMANTESK2_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANF110A_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANKI13B_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANLRFN1_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMANCBY1_HUMANBioGRID, IntAct27173435 unassigned1312 details
AFAD_HUMAN1433T_HUMANBioGRID17353931 23444366 details
AFAD_HUMANRASN_HUMANBioGRID12808105 details
AFAD_HUMANKMT2A_HUMANBioGRID16239140 details
AFAD_HUMANMEN1_HUMANBioGRID16239140 details
AFAD_HUMAN1433E_HUMANBioGRID17979178 details
AFAD_HUMANGRB2_HUMANBioGRID21706016 details
AFAD_HUMANRN146_HUMANBioGRID27521426 details
AFAD_HUMANHDAC6_HUMANBioGRID31264358 details