Entity Details

Primary name SIK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP57059
EntryNameSIK1_HUMAN
FullNameSerine/threonine-protein kinase SIK1
TaxID9606
Evidenceevidence at protein level
Length783
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesSIK1B
SIK1

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0002028 regulation of sodium ion transport
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0007346 regulation of mitotic cell cycle
GO:0008140 cAMP response element binding protein binding
GO:0010830 regulation of myotube differentiation
GO:0010868 negative regulation of triglyceride biosynthetic process
GO:0019901 protein kinase binding
GO:0032792 negative regulation of CREB transcription factor activity
GO:0035556 intracellular signal transduction
GO:0042149 cellular response to glucose starvation
GO:0043153 entrainment of circadian clock by photoperiod
GO:0045595 regulation of cell differentiation
GO:0045721 negative regulation of gluconeogenesis
GO:0046777 protein autophosphorylation
GO:0048511 rhythmic process
GO:0055007 cardiac muscle cell differentiation
GO:0071889 14-3-3 protein binding
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:2000210 positive regulation of anoikis

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR015940 Ubiquitin-associated domainDomainDomain
IPR017090 Serine/threonine-protein kinase, SIK1/2FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR034672 Salt-Inducible kinase, catalytic domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB08912 DabrafenibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule