Entity Details

Primary name SESN3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP58005
EntryNameSESN3_HUMAN
FullNameSestrin-3
TaxID9606
Evidenceevidence at protein level
Length492
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesSESN3

GO terms

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GOName
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016239 positive regulation of macroautophagy
GO:0016684 oxidoreductase activity, acting on peroxide as acceptor
GO:0031932 TORC2 complex
GO:0032868 response to insulin
GO:0034198 cellular response to amino acid starvation
GO:0038203 TORC2 signaling
GO:0042149 cellular response to glucose starvation
GO:0042593 glucose homeostasis
GO:0046626 regulation of insulin receptor signaling pathway
GO:0051896 regulation of protein kinase B signaling
GO:0070728 leucine binding
GO:0071233 cellular response to leucine
GO:1901031 regulation of response to reactive oxygen species
GO:1904262 negative regulation of TORC1 signaling
GO:1990253 cellular response to leucine starvation

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR006730 SestrinFamilyFamily
IPR029032 AhpD-likeFamilyHomologous superfamily

Diseases

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Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
SESN3_HUMANWDR24_HUMANBioGRID, DIP, IntAct25263562 26449471 details
SESN3_HUMANWDR59_HUMANBioGRID, IntAct25263562 details
SESN3_HUMANNPRL3_HUMANBioGRID, IntAct25263562 details
SESN3_HUMANMIO_HUMANBioGRID25263562 details