Entity Details

Primary name KCNJ2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP63252
EntryNameKCNJ2_HUMAN
FullNameInward rectifier potassium channel 2
TaxID9606
Evidenceevidence at protein level
Length427
SequenceStatuscomplete
DateCreated2004-10-11
DateModified2021-06-02

Ontological Relatives

GenesKCNJ2

GO terms

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GOName
GO:0005242 inward rectifier potassium channel activity
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005790 smooth endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006813 potassium ion transport
GO:0008076 voltage-gated potassium channel complex
GO:0014704 intercalated disc
GO:0014861 regulation of skeletal muscle contraction via regulation of action potential
GO:0015693 magnesium ion transport
GO:0030007 cellular potassium ion homeostasis
GO:0030315 T-tubule
GO:0031224 intrinsic component of membrane
GO:0034765 regulation of ion transmembrane transport
GO:0042802 identical protein binding
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0051289 protein homotetramerization
GO:0055119 relaxation of cardiac muscle
GO:0060075 regulation of resting membrane potential
GO:0060306 regulation of membrane repolarization
GO:0061337 cardiac conduction
GO:0071260 cellular response to mechanical stimulus
GO:0071805 potassium ion transmembrane transport
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086004 regulation of cardiac muscle cell contraction
GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
GO:0086011 membrane repolarization during action potential
GO:0086012 membrane depolarization during cardiac muscle cell action potential
GO:0086013 membrane repolarization during cardiac muscle cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:0090076 relaxation of skeletal muscle
GO:1901381 positive regulation of potassium ion transmembrane transport
GO:1990573 potassium ion import across plasma membrane

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR003271 Potassium channel, inwardly rectifying, Kir2.1FamilyFamily
IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmicFamilyHomologous superfamily
IPR013673 Potassium channel, inwardly rectifying, Kir, N-terminalDomainDomain
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR016449 Potassium channel, inwardly rectifying, KirFamilyFamily
IPR040445 Potassium channel, inwardly rectifying, transmembrane domainDomainDomain
IPR041647 Inward rectifier potassium channel, C-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00243 RanolazineDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB01136 CarvedilolDrugbanksmall molecule
DB04855 DronedaroneDrugbanksmall molecule