Entity Details

Primary name IRX3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP78415
EntryNameIRX3_HUMAN
FullNameIroquois-class homeodomain protein IRX-3
TaxID9606
Evidenceevidence at transcript level
Length501
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesIRX3

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001216 DNA-binding transcription activator activity
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001656 metanephros development
GO:0003165 Purkinje myocyte development
GO:0003167 atrioventricular bundle cell differentiation
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007498 mesoderm development
GO:0030182 neuron differentiation
GO:0030424 axon
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048468 cell development
GO:0060932 His-Purkinje system cell differentiation
GO:0072086 specification of loop of Henle identity
GO:0097009 energy homeostasis
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1903598 positive regulation of gap junction assembly
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001356 Homeobox domainDomainDomain
IPR003893 Iroquois-class homeodomain proteinDomainDomain
IPR008422 Homeobox KN domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site

Diseases

Show/Hide Table

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
IRX3_HUMANHSC20_HUMANDIP24606901 details