Entity Details

Primary name NKX61_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP78426
EntryNameNKX61_HUMAN
FullNameHomeobox protein Nkx-6.1
TaxID9606
Evidenceevidence at protein level
Length367
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesNKX6-1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001764 neuron migration
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0007224 smoothened signaling pathway
GO:0009887 animal organ morphogenesis
GO:0021953 central nervous system neuron differentiation
GO:0030154 cell differentiation
GO:0030516 regulation of axon extension
GO:0031016 pancreas development
GO:0032024 positive regulation of insulin secretion
GO:0035094 response to nicotine
GO:0042493 response to drug
GO:0044342 type B pancreatic cell proliferation
GO:0045666 positive regulation of neuron differentiation
GO:0045686 negative regulation of glial cell differentiation
GO:0045687 positive regulation of glial cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048709 oligodendrocyte differentiation
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051594 detection of glucose
GO:0070062 extracellular exosome
GO:0071345 cellular response to cytokine stimulus
GO:0071375 cellular response to peptide hormone stimulus
GO:0072560 type B pancreatic cell maturation
GO:2000078 positive regulation of type B pancreatic cell development
GO:2001222 regulation of neuron migration

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000047 Helix-turn-helix motifSiteConserved site
IPR001356 Homeobox domainDomainDomain
IPR009057 Homeobox-like domain superfamilyFamilyHomologous superfamily
IPR017970 Homeobox, conserved siteSiteConserved site
IPR020479 Homeobox domain, metazoaDomainDomain
IPR033630 Homeobox protein NKX-6.1FamilyFamily

Diseases

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Interactions

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