Entity Details

Primary name HSF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ00613
EntryNameHSF1_HUMAN
FullNameHeat shock factor protein 1
TaxID9606
Evidenceevidence at protein level
Length529
SequenceStatuscomplete
DateCreated1994-02-01
DateModified2021-06-02

Ontological Relatives

GenesHSF1

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000165 MAPK cascade
GO:0000776 kinetochore
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0000792 heterochromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006281 DNA repair
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006397 mRNA processing
GO:0006952 defense response
GO:0007584 response to nutrient
GO:0008284 positive regulation of cell population proliferation
GO:0009299 mRNA transcription
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0014823 response to activity
GO:0016032 viral process
GO:0016605 PML body
GO:0019901 protein kinase binding
GO:0031072 heat shock protein binding
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031490 chromatin DNA binding
GO:0033574 response to testosterone
GO:0034605 cellular response to heat
GO:0034620 cellular response to unfolded protein
GO:0034622 cellular protein-containing complex assembly
GO:0035865 cellular response to potassium ion
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042802 identical protein binding
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0043621 protein self-association
GO:0045651 positive regulation of macrophage differentiation
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046982 protein heterodimerization activity
GO:0048471 perinuclear region of cytoplasm
GO:0051028 mRNA transport
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051879 Hsp90 protein binding
GO:0061408 positive regulation of transcription from RNA polymerase II promoter in response to heat stress
GO:0061770 translation elongation factor binding
GO:0070301 cellular response to hydrogen peroxide
GO:0071222 cellular response to lipopolysaccharide
GO:0071276 cellular response to cadmium ion
GO:0071280 cellular response to copper ion
GO:0071392 cellular response to estradiol stimulus
GO:0071480 cellular response to gamma radiation
GO:0072738 cellular response to diamide
GO:0090084 negative regulation of inclusion body assembly
GO:0090261 positive regulation of inclusion body assembly
GO:0097165 nuclear stress granule
GO:0097431 mitotic spindle pole
GO:0097677 STAT family protein binding
GO:0098847 sequence-specific single stranded DNA binding
GO:0101031 chaperone complex
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1900034 regulation of cellular response to heat
GO:1900365 positive regulation of mRNA polyadenylation
GO:1901215 negative regulation of neuron death
GO:1902512 positive regulation of apoptotic DNA fragmentation
GO:1903936 cellular response to sodium arsenite
GO:1904385 cellular response to angiotensin
GO:1904528 positive regulation of microtubule binding
GO:1904843 cellular response to nitroglycerin
GO:1904845 cellular response to L-glutamine
GO:1990837 sequence-specific double-stranded DNA binding
GO:1990841 promoter-specific chromatin binding
GO:1990904 ribonucleoprotein complex
GO:1990910 response to hypobaric hypoxia
GO:1990911 response to psychosocial stress
GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000232 Heat shock factor (HSF)-type, DNA-bindingDomainDomain
IPR010542 Vertebrate heat shock transcription factor, C-terminal domainDomainDomain
IPR027725 Heat shock transcription factor familyFamilyFamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB06258 BimoclomolDrugbanksmall molecule

Interactions

116 interactions

InteractorPartnerSourcesPublicationsLink
HSF1_HUMANENOG_HUMANBioGRID, HPRD, IntAct16169070 details
HSF1_HUMANCHIP_HUMANBioGRID, HPRD, MINT14532117 16293251 23344957 details
HSF1_HUMANMAPK2_HUMANBioGRID, HPRD, IntAct16278218 details
HSF1_HUMANCHSTA_HUMANBioGRID, IntAct21988832 details
HSF1_HUMANCDK6_HUMANBioGRID, IntAct22094256 details
HSF1_HUMANKPCT_HUMANIntAct23352416 details
HSF1_HUMANHSF2_HUMANBioGRID, DIP, HPRD, IntAct12813038 25036637 26186194 26496610 26727490 28514442 details
HSF1_HUMANMINK1_HUMANMINT25816751 details
HSF1_HUMANPLK1_HUMANBioGRID, IntAct18794143 27173435 unassigned1312 details
HSF1_HUMANHSP7C_HUMANBioGRID, HPRD, IntAct16293251 28514442 7639722 details
HSF1_HUMANSUMO1_HUMANBioGRID, DIP, HPRD12646186 12665592 19684601 22748127 details
HSF1_HUMANHSF1_HUMANBioGRID, DIP, HPRD, IntAct12865437 19758120 20098725 26727490 29997244 details
HSF1_HUMANMK08_HUMANBioGRID, DIP, HPRD10747973 27043084 details
HSF1_HUMANWDR88_HUMANIntAct32814053 details
HSF1_HUMANRUSD4_HUMANIntAct32814053 details
HSF1_HUMANT185A_HUMANIntAct32814053 details
HSF1_HUMANKLF15_HUMANIntAct32814053 details
HSF1_HUMANCENPR_HUMANIntAct32814053 details
HSF1_HUMANLPIN1_HUMANIntAct32814053 details
HSF1_HUMANANM5_HUMANIntAct32814053 details
HSF1_HUMANZN232_HUMANIntAct32814053 details
HSF1_HUMANUTER_HUMANIntAct32814053 details
HSF1_HUMANSYMPK_HUMANBioGRID, HPRD14707147 details
HSF1_HUMANRBP1_HUMANBioGRID12621024 details
HSF1_HUMANHS90A_HUMANBioGRID11583998 12621024 16278218 18599869 20885985 22367781 26517842 9222609 details
HSF1_HUMANHSP74_HUMANBioGRID14532117 1628823 20565132 9222609 details
HSF1_HUMANFKBP5_HUMANBioGRID9222609 details
HSF1_HUMANFKBP4_HUMANBioGRID11583998 9222609 details
HSF1_HUMANPPID_HUMANBioGRID9222609 details
HSF1_HUMANTEBP_HUMANBioGRID23022381 9222609 details
HSF1_HUMANHS71A_HUMANBioGRID, HPRD1628823 21784850 9499401 9699716 details
HSF1_HUMANHS71B_HUMANBioGRID, HPRD1628823 21784850 9499401 9699716 details
HSF1_HUMANDNJB1_HUMANBioGRID, HPRD9499401 details
HSF1_HUMANTBP_HUMANBioGRID, HPRD11005381 details
HSF1_HUMANTF2B_HUMANBioGRID, HPRD11005381 details
HSF1_HUMANCEBPB_HUMANBioGRID, HPRD11801594 details
HSF1_HUMANXRCC5_HUMANBioGRID, HPRD9325337 details
HSF1_HUMANPRKDC_HUMANBioGRID, HPRD9325337 details
HSF1_HUMANXRCC6_HUMANBioGRID, HPRD11162511 details
HSF1_HUMANHSBP1_HUMANBioGRID, HPRD9649501 details
HSF1_HUMANMTA1_HUMANBioGRID17922035 details
HSF1_HUMANFLIP1_HUMANBioGRID21784850 details
HSF1_HUMANCDC20_HUMANBioGRID18059335 18794143 details
HSF1_HUMANTAF9_HUMANBioGRID, HPRD10821850 11005381 details
HSF1_HUMANUBC9_HUMANBioGRID19684601 details
HSF1_HUMANDAXX_HUMANBioGRID15016915 20620219 details
HSF1_HUMANMK01_HUMANBioGRID10747973 details
HSF1_HUMANNCOA6_HUMANBioGRID14960326 details
HSF1_HUMANCBP_HUMANBioGRID, HPRD14960326 details
HSF1_HUMANHS90B_HUMANBioGRID26517842 details
HSF1_HUMANBRE1A_HUMANBioGRID30649429 details
HSF1_HUMANEF1D_HUMANBioGRID30649429 details
HSF1_HUMANPIM2_HUMANBioGRID31409638 details
HSF1_HUMANREPS1_HUMANHPRD12621024 details
HSF1_HUMANTTC5_HUMANMINT18451878 details
HSF1_HUMAN1433E_HUMANHPRD, MINT12917326 15364926 details
HSF1_HUMANEF1G_HUMANMINT21597468 details
HSF1_HUMANIMA4_HUMANBioGRID, IntAct25036637 27173435 unassigned1312 details
HSF1_HUMANBAG3_HUMANBioGRID, IntAct23824909 25036637 27173435 unassigned1312 details
HSF1_HUMANHPBP1_HUMANBioGRID, IntAct25036637 27173435 28514442 unassigned1312 details
HSF1_HUMANHSPB1_HUMANBioGRID, IntAct19597476 25036637 details
HSF1_HUMANIMA3_HUMANBioGRID, IntAct25036637 27173435 unassigned1312 details
HSF1_HUMANLMNA_HUMANMINT25425574 details
HSF1_HUMANIER5_HUMANMINT25816751 26496226 details
HSF1_HUMANRTL9_HUMANBioGRID, IntAct27173435 unassigned1312 details
HSF1_HUMANCARL1_HUMANBioGRID, IntAct27173435 unassigned1312 details
HSF1_HUMANHS71L_HUMANBioGRID, IntAct27173435 unassigned1312 details
HSF1_HUMANBUB1_HUMANBioGRID, IntAct27173435 unassigned1312 details
HSF1_HUMANSMC6_HUMANBioGRID, IntAct27173435 unassigned1312 details
HSF1_HUMANU5S1_HUMANBioGRID, IntAct27173435 unassigned1312 details
HSF1_HUMANMNS1_HUMANBioGRID, IntAct27173435 unassigned1312 details
HSF1_HUMANTF3C4_HUMANBioGRID, IntAct27173435 unassigned1312 details
HSF1_HUMANEP15R_HUMANBioGRID, IntAct27173435 unassigned1312 details
HSF1_HUMANMARE2_HUMANBioGRID, IntAct27173435 unassigned1312 details
HSF1_HUMANGAPD1_HUMANBioGRID, IntAct27173435 unassigned1312 details
HSF1_HUMANSMC1A_HUMANBioGRID, IntAct27173435 unassigned1312 details
HSF1_HUMANMCM6_HUMANBioGRID, IntAct27173435 unassigned1312 details
HSF1_HUMANDCAF7_HUMANBioGRID, IntAct27173435 unassigned1312 details
HSF1_HUMANRAB28_HUMANBioGRID, IntAct27173435 unassigned1312 details
HSF1_HUMANMCM2_HUMANBioGRID, IntAct27173435 unassigned1312 details
HSF1_HUMANMCM4_HUMANBioGRID, IntAct27173435 unassigned1312 details
HSF1_HUMANJIP4_HUMANBioGRID, IntAct27173435 unassigned1312 details
HSF1_HUMANUBP15_HUMANBioGRID, IntAct27173435 unassigned1312 details
HSF1_HUMANNS1BP_HUMANBioGRID, IntAct27173435 unassigned1312 details
HSF1_HUMANCFA20_HUMANBioGRID, IntAct27173435 unassigned1312 details
HSF1_HUMANCEP63_HUMANIntAct31413325 details
HSF1_HUMANSMCA4_HUMANBioGRID11486022 20353823 21079652 details
HSF1_HUMANSNF5_HUMANBioGRID11486022 details
HSF1_HUMANSTAT1_HUMANBioGRID, HPRD9880553 details
HSF1_HUMANSIR1_HUMANBioGRID19229036 details
HSF1_HUMANHDAC1_HUMANBioGRID17922035 19793920 details
HSF1_HUMANHDAC2_HUMANBioGRID17922035 19793920 details
HSF1_HUMANCHD3_HUMANBioGRID17922035 details
HSF1_HUMANHSPB2_HUMANBioGRID19597476 details
HSF1_HUMANPCGF2_HUMANBioGRID18211895 details
HSF1_HUMANFBW1A_HUMANBioGRID18794143 details
HSF1_HUMANMD2L1_HUMANBioGRID18794143 details
HSF1_HUMANSTRAP_HUMANBioGRID18451878 details
HSF1_HUMANFBXW7_HUMANBioGRID25720964 31244938 31409638 details
HSF1_HUMANNEDD4_HUMANBioGRID26503960 details
HSF1_HUMANEP300_HUMANBioGRID28104499 details
HSF1_HUMANHYPK_HUMANBioGRID23272104 details
HSF1_HUMANPSD10_HUMANBioGRID25905985 details
HSF1_HUMANTRI11_HUMANBioGRID30563406 details
HSF1_HUMANPDK3_HUMANBioGRID31244938 details
HSF1_HUMANGSK3B_HUMANBioGRID31244938 details
HSF1_HUMANMK03_HUMANBioGRID, HPRD31244938 8940068 details
HSF1_HUMANP53_HUMANBioGRID32097779 details
HSF1_HUMANCSK21_HUMANHPRD12659875 details
HSF1_HUMANSUMO3_HUMANHPRD15576338 details
HSF1_HUMANTAF1_HUMANHPRD11005381 details
HSF1_HUMANTCP4_HUMANHPRD11005381 details
HSF1_HUMANT2AG_HUMANHPRD11005381 details
HSF1_HUMANMK09_HUMANHPRD11527157 details
HSF1_HUMANGSK3A_HUMANHPRD12665592 details
HSF1_HUMANTAF7_HUMANHPRD11005381 details