Entity Details

Primary name E2F1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ01094
EntryNameE2F1_HUMAN
FullNameTranscription factor E2F1
TaxID9606
Evidenceevidence at protein level
Length437
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesE2F1

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001216 DNA-binding transcription activator activity
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005813 centrosome
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007283 spermatogenesis
GO:0008134 transcription factor binding
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0010628 positive regulation of gene expression
GO:0016032 viral process
GO:0019901 protein kinase binding
GO:0030851 granulocyte differentiation
GO:0030900 forebrain development
GO:0032991 protein-containing complex
GO:0035189 Rb-E2F complex
GO:0043065 positive regulation of apoptotic process
GO:0043276 anoikis
GO:0043392 negative regulation of DNA binding
GO:0043565 sequence-specific DNA binding
GO:0045599 negative regulation of fat cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046983 protein dimerization activity
GO:0048146 positive regulation of fibroblast proliferation
GO:0048255 mRNA stabilization
GO:0060252 positive regulation of glial cell proliferation
GO:0070317 negative regulation of G0 to G1 transition
GO:0070345 negative regulation of fat cell proliferation
GO:0071398 cellular response to fatty acid
GO:0071456 cellular response to hypoxia
GO:0071466 cellular response to xenobiotic stimulus
GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0090575 RNA polymerase II transcription regulator complex
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1990086 lens fiber cell apoptotic process
GO:1990090 cellular response to nerve growth factor stimulus
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000045 regulation of G1/S transition of mitotic cell cycle

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR003316 E2F/DP family, winged-helix DNA-binding domainDomainDomain
IPR015633 E2F FamilyFamilyFamily
IPR032198 E2F transcription factor, CC-MB domainDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily
IPR037241 E2F-DP heterodimerization regionFamilyHomologous superfamily

Diseases

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Interactions

147 interactions

InteractorPartnerSourcesPublicationsLink
E2F1_HUMANTOPB1_HUMANBioGRID, HPRD, MINT12697828 14576432 14576433 17006541 20413589 28439015 details
E2F1_HUMANRB_HUMANBioGRID, DIP, HPRD, I2D, IntAct, MINT, UniProt10207050 10393912 10499802 10869426 10891495 11090181 11470869 11583618 11713253 11839806 12096339 12397079 12401786 12502741 12598654 12947005 12963846 1388726 15485814 15485920 15619620 15670817 15837424 16249186 16360038 16374512 16496386 16766265 17380128 18216119 18391203 19058874 19249677 19477924 20871633 21085491 21602887 22078878 22768064 23001041 23472054 24981860 25257171 28074012 28542143 29521627 30867845 31130363 7739537 7828850 7958924 8230483 8255752 8346196 8449399 8458319 8626527 8657117 8816798 8896460 9125176 9219533 9315635 9400991 9422723 9501179 9553123 9632788 details
E2F1_HUMANSP1_HUMANBioGRID, HPRD, IntAct10409740 10547281 10850422 8657141 8657142 details
E2F1_HUMANDDB2_HUMANBioGRID, HPRD, IntAct9418871 details
E2F1_HUMANPARP1_HUMANBioGRID, DIP, HPRD, IntAct14627987 20133863 details
E2F1_HUMANBTG3_HUMANMINT17690688 details
E2F1_HUMANMCPH1_HUMANBioGRID, MINT18660752 23001041 23697381 details
E2F1_HUMANCCNA2_HUMANBioGRID, HPRD, IntAct, NTNU12501191 16179649 19249677 7969176 8458319 9724724 details
E2F1_HUMANNCOR2_HUMANBioGRID, IntAct20195357 details
E2F1_HUMANSTAT1_HUMANBioGRID, IntAct20195357 details
E2F1_HUMANSTML1_HUMANBioGRID, IntAct20195357 details
E2F1_HUMANSIR1_HUMANBioGRID, UniProt16892051 19188449 24112038 details
E2F1_HUMANTFDP1_HUMANBioGRID, HPRD, IntAct, MINT15133492 16360038 20211142 22327218 22629304 24981860 25368385 27705803 28542143 30867845 31130363 7739537 7892279 8405995 8816502 8816798 8832394 9199321 9501179 9704927 9780002 details
E2F1_HUMANRBL1_HUMANBioGRID, IntAct12096339 12401786 1530885 16360038 20040599 23853093 8230483 8458319 8657117 9501179 details
E2F1_HUMANTFDP2_HUMANBioGRID, HPRD, IntAct26186194 28514442 7739537 8755520 9368098 9501179 9704927 details
E2F1_HUMANNCOA3_HUMANBioGRID, DIP, HPRD15169882 16648476 16938873 details
E2F1_HUMANHCFC1_HUMANBioGRID, DIP17612494 20622854 details
E2F1_HUMANRRP1B_HUMANIntAct20040599 details
E2F1_HUMANDBLOH_HUMANBioGRID, MINT18660514 30359437 details
E2F1_HUMANA4_HUMANIntAct32814053 details
E2F1_HUMANNECD_HUMANBioGRID, HPRD14593116 9422723 details
E2F1_HUMANNCOA6_HUMANBioGRID, HPRD14638867 details
E2F1_HUMANPHB_HUMANBioGRID, HPRD10523633 12065415 14500729 14637159 15141164 details
E2F1_HUMANNSE3_HUMANBioGRID14593116 details
E2F1_HUMANIPKB_HUMANBioGRID12748276 details
E2F1_HUMANCBP_HUMANBioGRID, HPRD12748276 8932363 details
E2F1_HUMANTEAD3_HUMANBioGRID12748276 details
E2F1_HUMANMYBB_HUMANBioGRID12748276 details
E2F1_HUMANSPIB_HUMANBioGRID12748276 details
E2F1_HUMANMGAP_HUMANBioGRID12748276 details
E2F1_HUMANTP53B_HUMANBioGRID, HPRD8896460 details
E2F1_HUMANMDM4_HUMANBioGRID, HPRD12532331 details
E2F1_HUMANR144A_HUMANBioGRID12411495 details
E2F1_HUMANFHL2_HUMANBioGRID12411495 details
E2F1_HUMANCDK2_HUMANBioGRID11245432 1530885 7969176 8458319 9199321 details
E2F1_HUMANSP2_HUMANBioGRID, HPRD10547281 details
E2F1_HUMANSP4_HUMANBioGRID, HPRD10547281 details
E2F1_HUMANSP3_HUMANBioGRID, HPRD10547281 details
E2F1_HUMANNPDC1_HUMANBioGRID, HPRD11042687 9181131 details
E2F1_HUMANNFKB1_HUMANBioGRID, HPRD9368006 details
E2F1_HUMANARI3A_HUMANBioGRID, HPRD9780002 details
E2F1_HUMANCCNA1_HUMANBioGRID, HPRD10022926 16774918 details
E2F1_HUMANSKP2_HUMANBioGRID, HPRD10559858 12097298 16170383 17471231 23868976 27720894 details
E2F1_HUMANCUL1_HUMANBioGRID, HPRD10559858 details
E2F1_HUMANTF2H1_HUMANBioGRID, HPRD10428966 9400991 details
E2F1_HUMANPURA_HUMANBioGRID, HPRD10597240 15517862 details
E2F1_HUMANMDM2_HUMANBioGRID16170383 18754770 32453417 details
E2F1_HUMANTBP_HUMANBioGRID17111193 8255752 9400991 details
E2F1_HUMAN1433T_HUMANBioGRID15494392 details
E2F1_HUMANNRIP1_HUMANBioGRID20410059 22629304 details
E2F1_HUMANKDM1A_HUMANBioGRID20603083 21320024 details
E2F1_HUMANSETD7_HUMANBioGRID20603083 21320024 22836579 details
E2F1_HUMANPRDM2_HUMANBioGRID9223517 details
E2F1_HUMANATM_HUMANBioGRID, HPRD11459832 details
E2F1_HUMANATR_HUMANBioGRID, HPRD11459832 details
E2F1_HUMANATAD2_HUMANBioGRID20855524 details
E2F1_HUMANIGF1_HUMANBioGRID14681231 details
E2F1_HUMANFZR1_HUMANBioGRID22580462 27903963 details
E2F1_HUMANBIRC2_HUMANBioGRID21653699 28542143 30359437 details
E2F1_HUMANCDK1_HUMANBioGRID, HPRD8087847 9199321 details
E2F1_HUMANCDN2A_HUMANBioGRID11314038 16135794 20106982 details
E2F1_HUMANARF_HUMANBioGRID, HPRD11314038 16135794 20106982 details
E2F1_HUMANCEBPE_HUMANBioGRID, HPRD12947005 details
E2F1_HUMANERCC3_HUMANBioGRID9400991 details
E2F1_HUMANRARA_HUMANBioGRID24608861 details
E2F1_HUMANVHL_HUMANBioGRID24112038 details
E2F1_HUMANEP300_HUMANBioGRID15123636 23001041 24112038 9652736 details
E2F1_HUMANKDM2A_HUMANBioGRID25029110 details
E2F1_HUMANBRMS1_HUMANBioGRID14581478 details
E2F1_HUMANFBW1A_HUMANBioGRID11245432 details
E2F1_HUMANBIN1_HUMANBioGRID25257171 30733337 details
E2F1_HUMANRN126_HUMANBioGRID26234677 details
E2F1_HUMANUCHL5_HUMANBioGRID26396186 details
E2F1_HUMANUBE3A_HUMANBioGRID28074012 details
E2F1_HUMANCUL2_HUMANBioGRID27153550 details
E2F1_HUMANP53_HUMANBioGRID, HPRD11739724 24076372 8557038 details
E2F1_HUMANGABP1_HUMANBioGRID11884602 details
E2F1_HUMANMTA1_HUMANBioGRID30867845 details
E2F1_HUMANTRRAP_HUMANBioGRID, HPRD, IntAct11418595 18542057 9708738 details
E2F1_HUMANPA2G4_HUMANUniProt11268000 details
E2F1_HUMANANM2_HUMANBioGRID, IntAct16616919 details
E2F1_HUMANARI4B_HUMANIntAct20195357 details
E2F1_HUMANCWC27_HUMANIntAct20195357 details
E2F1_HUMANUBXN1_HUMANIntAct20195357 details
E2F1_HUMANTBA4A_HUMANIntAct20195357 details
E2F1_HUMANNGRN_HUMANIntAct20195357 details
E2F1_HUMANNCHL1_HUMANIntAct20195357 details
E2F1_HUMANTRI16_HUMANBioGRID, I2D20729920 details
E2F1_HUMANKAT2B_HUMANBioGRID, Molecular Connections, UniProt15123636 19188449 23001041 24112038 24502362 details
E2F1_HUMANANM5_HUMANMINT22327218 details
E2F1_HUMANIF16_HUMANUniProt12894224 details
E2F1_HUMANEZH2_HUMANBioGRID, IntAct23238014 24771265 details
E2F1_HUMANCDK7_HUMANBioGRID, HPRD, IntAct10428966 20106982 23397142 details
E2F1_HUMANCDC6_HUMANIntAct23397142 details
E2F1_HUMANE2F1_HUMANBioGRID, IntAct, NTNU16179649 20040599 20106982 details
E2F1_HUMANRING1_HUMANBioGRID, IntAct11583618 27705803 details
E2F1_HUMANKAT2A_HUMANBioGRID, IntAct, Molecular Connections11418595 20972224 24502362 details
E2F1_HUMANLMBL3_HUMANBioGRID, DIP17517653 29691401 details
E2F1_HUMANCDK8_HUMANDIP18794899 details
E2F1_HUMANHDAC1_HUMANBioGRID, DIP10734134 17980157 26468294 9468139 9468140 details
E2F1_HUMANPAWR_HUMANMINT18660514 details
E2F1_HUMANDNMT1_HUMANBioGRID10888886 details
E2F1_HUMANRBBP4_HUMANBioGRID10734134 details
E2F1_HUMANBRD2_HUMANBioGRID, HPRD10965846 17111193 details
E2F1_HUMANGSK3B_HUMANBioGRID, HPRD18367454 details
E2F1_HUMANUBC_HUMANBioGRID17630509 details
E2F1_HUMANKLF6_HUMANBioGRID18521079 details
E2F1_HUMANCDN1A_HUMANBioGRID15964998 details
E2F1_HUMANKAT5_HUMANBioGRID, HPRD15121871 details
E2F1_HUMANLEF1_HUMANBioGRID17980157 details
E2F1_HUMANTIF1B_HUMANBioGRID17704056 22496453 details
E2F1_HUMANASH2L_HUMANBioGRID17612494 details
E2F1_HUMANKC1A_HUMANBioGRID19759023 details
E2F1_HUMANAPC5_HUMANBioGRID22580462 25368385 details
E2F1_HUMANANDR_HUMANBioGRID22508987 details
E2F1_HUMANESR1_HUMANBioGRID22216287 details
E2F1_HUMANBRCA1_HUMANBioGRID, HPRD11278247 21880590 9244350 details
E2F1_HUMANDDB1_HUMANBioGRID9418871 details
E2F1_HUMANXIAP_HUMANBioGRID21653699 25216527 details
E2F1_HUMANBIRC3_HUMANBioGRID21653699 details
E2F1_HUMANCEBPD_HUMANBioGRID15674331 details
E2F1_HUMANCCNE1_HUMANBioGRID12096339 details
E2F1_HUMANRBL2_HUMANBioGRID12096339 12401786 details
E2F1_HUMANUHRF2_HUMANBioGRID23833190 details
E2F1_HUMANMAGAB_HUMANBioGRID23853093 27720894 details
E2F1_HUMANLTOR5_HUMANBioGRID23352642 details
E2F1_HUMANCDC20_HUMANBioGRID20948288 25368385 details
E2F1_HUMANCDC27_HUMANBioGRID25368385 details
E2F1_HUMANAPC11_HUMANBioGRID25368385 details
E2F1_HUMANAPC7_HUMANBioGRID25368385 details
E2F1_HUMANCADH1_HUMANBioGRID20948288 details
E2F1_HUMANPSDE_HUMANBioGRID26510456 30590814 details
E2F1_HUMANPTN11_HUMANBioGRID27720894 details
E2F1_HUMANSMCA2_HUMANBioGRID9326598 details
E2F1_HUMANCDN1C_HUMANBioGRID20106982 details
E2F1_HUMANE2F3_HUMANBioGRID20106982 24981860 details
E2F1_HUMANAHR_HUMANBioGRID18524851 details
E2F1_HUMANDCAF5_HUMANBioGRID29691401 details
E2F1_HUMANNBN_HUMANBioGRID21512314 30733337 details
E2F1_HUMANCCNF_HUMANBioGRID31130363 details
E2F1_HUMANZBT7A_HUMANBioGRID31444154 details
E2F1_HUMANE2F6_HUMANBioGRID, HPRD24981860 9689056 details
E2F1_HUMANMAT1_HUMANHPRD10428966 details
E2F1_HUMANCHK2_HUMANHPRD12717439 details
E2F1_HUMANCTDP1_HUMANHPRD14576433 details
E2F1_HUMANSRTD2_HUMANHPRD11331592 details
E2F1_HUMANCDK3_HUMANHPRD11733001 8846921 details