Entity Details

Primary name CAC1D_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ01668
EntryNameCAC1D_HUMAN
FullNameVoltage-dependent L-type calcium channel subunit alpha-1D
TaxID9606
Evidenceevidence at protein level
Length2161
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesCACNA1D

GO terms

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GOName
GO:0005245 voltage-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0006816 calcium ion transport
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway
GO:0007605 sensory perception of sound
GO:0030018 Z disc
GO:0030506 ankyrin binding
GO:0045762 positive regulation of adenylate cyclase activity
GO:0046872 metal ion binding
GO:0050796 regulation of insulin secretion
GO:0051393 alpha-actinin binding
GO:0051928 positive regulation of calcium ion transport
GO:0060372 regulation of atrial cardiac muscle cell membrane repolarization
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential
GO:0086012 membrane depolarization during cardiac muscle cell action potential
GO:0086046 membrane depolarization during SA node cell action potential
GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:1901016 regulation of potassium ion transmembrane transporter activity
GO:1901379 regulation of potassium ion transmembrane transport
GO:1990454 L-type voltage-gated calcium channel complex

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR002077 Voltage-dependent calcium channel, alpha-1 subunitFamilyFamily
IPR005446 Voltage-dependent calcium channel, L-type, alpha-1 subunitFamilyFamily
IPR005452 Voltage-dependent calcium channel, L-type, alpha-1D subunitFamilyFamily
IPR005821 Ion transport domainDomainDomain
IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domainDomainDomain
IPR027359 Voltage-dependent channel domain superfamilyFamilyHomologous superfamily
IPR031649 Voltage-dependent L-type calcium channel, IQ-associated domainDomainDomain
IPR031688 Voltage-gated calcium channel subunit alpha, C-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00153 ErgocalciferolDrugbanksmall molecule
DB00228 EnfluraneDrugbanksmall molecule
DB00243 RanolazineDrugbanksmall molecule
DB00252 PhenytoinDrugbanksmall molecule
DB00270 IsradipineDrugbanksmall molecule
DB00273 TopiramateDrugbanksmall molecule
DB00393 NimodipineDrugbanksmall molecule
DB00401 NisoldipineDrugbanksmall molecule
DB00421 SpironolactoneDrugbanksmall molecule
DB00568 CinnarizineDrugbanksmall molecule
DB00622 NicardipineDrugbanksmall molecule
DB00653 Magnesium sulfateDrugbanksmall molecule
DB00825 LevomentholDrugbanksmall molecule
DB00898 EthanolDrugbanksmall molecule
DB01023 FelodipineDrugbanksmall molecule
DB01054 NitrendipineDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB01115 NifedipineDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01388 MibefradilDrugbanksmall molecule
DB04855 DronedaroneDrugbanksmall molecule
DB04920 ClevidipineDrugbanksmall molecule
DB06712 NilvadipineDrugbanksmall molecule
DB09089 TrimebutineDrugbanksmall molecule
DB09229 AranidipineDrugbanksmall molecule
DB09231 BenidipineDrugbanksmall molecule
DB09232 CilnidipineDrugbanksmall molecule
DB09236 LacidipineDrugbanksmall molecule
DB09237 LevamlodipineDrugbanksmall molecule
DB09238 ManidipineDrugbanksmall molecule
DB11093 Calcium citrateDrugbanksmall molecule
DB11148 ButambenDrugbanksmall molecule
DB11348 Calcium PhosphateDrugbanksmall molecule
DB13746 BioallethrinDrugbanksmall molecule
DB13961 Fish oilDrugbankbiotech
DB14481 Calcium phosphate dihydrateDrugbanksmall molecule