Entity Details

Primary name CAV1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ03135
EntryNameCAV1_HUMAN
FullNameCaveolin-1
TaxID9606
Evidenceevidence at protein level
Length178
SequenceStatuscomplete
DateCreated1993-10-01
DateModified2021-06-02

Ontological Relatives

GenesCAV1

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000139 Golgi membrane
GO:0000188 obsolete inactivation of MAPK activity
GO:0001525 angiogenesis
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0002080 acrosomal membrane
GO:0002095 caveolar macromolecular signaling complex
GO:0002931 response to ischemia
GO:0003057 regulation of the force of heart contraction by chemical signal
GO:0005102 signaling receptor binding
GO:0005113 patched binding
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005811 lipid droplet
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005901 caveola
GO:0005925 focal adhesion
GO:0005929 cilium
GO:0005938 cell cortex
GO:0006641 triglyceride metabolic process
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006940 regulation of smooth muscle contraction
GO:0007519 skeletal muscle tissue development
GO:0007595 lactation
GO:0008104 protein localization
GO:0009267 cellular response to starvation
GO:0009617 response to bacterium
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0010608 posttranscriptional regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010875 positive regulation of cholesterol efflux
GO:0015031 protein transport
GO:0015485 cholesterol binding
GO:0016020 membrane
GO:0016050 vesicle organization
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016504 peptidase activator activity
GO:0019065 receptor-mediated endocytosis of virus by host cell
GO:0019217 regulation of fatty acid metabolic process
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019915 lipid storage
GO:0030154 cell differentiation
GO:0030193 regulation of blood coagulation
GO:0030301 cholesterol transport
GO:0030335 positive regulation of cell migration
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0030666 endocytic vesicle membrane
GO:0030674 protein-macromolecule adaptor activity
GO:0030857 negative regulation of epithelial cell differentiation
GO:0030879 mammary gland development
GO:0031267 small GTPase binding
GO:0031295 T cell costimulation
GO:0031397 negative regulation of protein ubiquitination
GO:0031398 positive regulation of protein ubiquitination
GO:0031410 cytoplasmic vesicle
GO:0031623 receptor internalization
GO:0031901 early endosome membrane
GO:0032091 negative regulation of protein binding
GO:0032092 positive regulation of protein binding
GO:0032507 maintenance of protein location in cell
GO:0032570 response to progesterone
GO:0032991 protein-containing complex
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033484 nitric oxide homeostasis
GO:0034141 positive regulation of toll-like receptor 3 signaling pathway
GO:0038016 insulin receptor internalization
GO:0042310 vasoconstriction
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
GO:0042632 cholesterol homeostasis
GO:0042802 identical protein binding
GO:0043085 positive regulation of catalytic activity
GO:0043409 negative regulation of MAPK cascade
GO:0043627 response to estrogen
GO:0044325 transmembrane transporter binding
GO:0044860 protein localization to plasma membrane raft
GO:0044877 protein-containing complex binding
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045121 membrane raft
GO:0045907 positive regulation of vasoconstriction
GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT
GO:0046982 protein heterodimerization activity
GO:0048471 perinuclear region of cytoplasm
GO:0048550 negative regulation of pinocytosis
GO:0050900 leukocyte migration
GO:0050998 nitric-oxide synthase binding
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051001 negative regulation of nitric-oxide synthase activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051117 ATPase binding
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051592 response to calcium ion
GO:0051899 membrane depolarization
GO:0052547 regulation of peptidase activity
GO:0055074 calcium ion homeostasis
GO:0060056 mammary gland involution
GO:0060090 molecular adaptor activity
GO:0060355 positive regulation of cell adhesion molecule production
GO:0060546 negative regulation of necroptotic process
GO:0061099 negative regulation of protein tyrosine kinase activity
GO:0070320 inward rectifier potassium channel inhibitor activity
GO:0070836 caveola assembly
GO:0071360 cellular response to exogenous dsRNA
GO:0071375 cellular response to peptide hormone stimulus
GO:0071455 cellular response to hyperoxia
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071711 basement membrane organization
GO:0072584 caveolin-mediated endocytosis
GO:0086091 regulation of heart rate by cardiac conduction
GO:0086098 angiotensin-activated signaling pathway involved in heart process
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097190 apoptotic signaling pathway
GO:0098903 regulation of membrane repolarization during action potential
GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction
GO:0098911 regulation of ventricular cardiac muscle cell action potential
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1900027 regulation of ruffle assembly
GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation
GO:1901380 negative regulation of potassium ion transmembrane transport
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:1903361 protein localization to basolateral plasma membrane
GO:1903598 positive regulation of gap junction assembly
GO:1903609 negative regulation of inward rectifier potassium channel activity
GO:1904886 beta-catenin destruction complex disassembly
GO:2000286 receptor internalization involved in canonical Wnt signaling pathway
GO:2000535 regulation of entry of bacterium into host cell
GO:2000811 negative regulation of anoikis
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Golgi apparatus
Golgi apparatus membrane
Membrane
Membrane raft

Domains

Show/Hide Table
DomainNameCategoryType
IPR001612 CaveolinFamilyFamily
IPR015504 Caveolin-1FamilyFamily
IPR018361 Caveolin, conserved siteSiteConserved site

Diseases

Show/Hide Table
Disease IDSourceNameDescription
606721 OMIMLipodystrophy, familial partial, 7 (FPLD7)A form of partial lipodystrophy, a disorder characterized by abnormal subcutaneous fat distribution. Affected individuals manifest a gradual loss of subcutaneous adipose tissue in various parts of the body, accompanied by an accumulation of adipose tissue in the face and neck in some cases causing a double chin, fat neck, or cushingoid appearance. FPLD7 is an autosomal dominant form with a variable phenotype. Some patients manifest congenital cataracts and neurodegeneration leading to cerebellar and spinal cord dysfunction. The disease is caused by variants affecting the gene represented in this entry.
612526 OMIMCongenital generalized lipodystrophy 3 (CGL3)An autosomal recessive disorder characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. The disease is caused by variants affecting the gene represented in this entry.
615343 OMIMPulmonary hypertension, primary, 3 (PPH3)A rare disorder characterized by plexiform lesions of proliferating endothelial cells in pulmonary arterioles. The lesions lead to elevated pulmonary arterial pression, right ventricular failure, and death. The disease can occur from infancy throughout life and it has a mean age at onset of 36 years. Penetrance is reduced. Although familial pulmonary hypertension is rare, cases secondary to known etiologies are more common and include those associated with the appetite-suppressant drugs. The disease is caused by variants affecting the gene represented in this entry.

Interactions

189 interactions

InteractorPartnerSourcesPublicationsLink
CAV1_HUMANRASH_HUMANHPRD, MINT8621645 details
CAV1_HUMANSRC_HUMANBioGRID, HPRD, MINT29720121 8621645 8632005 8910575 details
CAV1_HUMANEGFR_HUMANBioGRID, DIP, HPRD, IntAct10781609 12354760 12388423 15273741 15657067 16407214 16799092 19446582 22411794 24658140 25402006 31980649 34079125 9374534 details
CAV1_HUMANSCP2_HUMANBioGRID, HPRD, IntAct15182174 details
CAV1_HUMANID1_HUMANBioGRID, IntAct17855368 details
CAV1_HUMANPTN1_HUMANBioGRID, HPRD, MINT12176037 16388599 details
CAV1_HUMANPTN11_HUMANBioGRID, HPRD, MINT12176037 24632723 25672415 details
CAV1_HUMANTRXR1_HUMANMINT19820694 details
CAV1_HUMANCSK_HUMANBioGRID, HPRD, MINT11805080 16678999 24632723 details
CAV1_HUMANRASA1_HUMANDIP, MINT15504032 20808760 details
CAV1_HUMANKCNH2_HUMANbhf-ucl18923542 details
CAV1_HUMANRAC1_HUMANBioGRID, HPIDb, HPRD15976327 20460433 24625804 27250250 details
CAV1_HUMANTRPC1_HUMANBioGRID, DIP, HPRD10980191 12732636 19052258 19897728 details
CAV1_HUMANVAV2_HUMANBioGRID, DIP20808760 details
CAV1_HUMANABL1_HUMANDIP, HPRD16151024 20808760 details
CAV1_HUMANSH2D3_HUMANDIP20808760 details
CAV1_HUMANPLCG1_HUMANBioGRID, DIP20808760 details
CAV1_HUMANGRB10_HUMANDIP20808760 details
CAV1_HUMANABL2_HUMANDIP20808760 details
CAV1_HUMANTERA_HUMANBioGRID, IntAct23335559 24089527 29599191 31980649 details
CAV1_HUMANKC1D_HUMANIntAct32814053 details
CAV1_HUMANA4_HUMANBioGRID, HPRD, IntAct32814053 9553108 details
CAV1_HUMANANDR_HUMANBioGRID, HPRD11278309 details
CAV1_HUMANEDNRB_HUMANBioGRID, HPRD12694195 details
CAV1_HUMANNOS2_HUMANBioGRID, HPRD11114180 details
CAV1_HUMANGRK5_HUMANBioGRID, HPRD10085129 details
CAV1_HUMANGRK1_HUMANBioGRID, HPRD10085129 details
CAV1_HUMANARBK1_HUMANBioGRID, HPRD10085129 details
CAV1_HUMANTNR16_HUMANBioGRID, HPRD9867838 details
CAV1_HUMANDAG1_HUMANBioGRID11724572 34079125 details
CAV1_HUMANESR1_HUMANBioGRID, HPRD11563984 19595769 22230296 details
CAV1_HUMANPGH2_HUMANBioGRID, HPRD11432874 19960513 24089527 details
CAV1_HUMANPGFRB_HUMANBioGRID10066366 details
CAV1_HUMANPGFRA_HUMANBioGRID, HPRD10066366 details
CAV1_HUMANCXA1_HUMANBioGRID, HPRD11980479 34079125 details
CAV1_HUMANRHOA_HUMANBioGRID, HPRD20460433 9647788 details
CAV1_HUMANRHOC_HUMANBioGRID20460433 details
CAV1_HUMANKCNA3_HUMANBioGRID18218624 26931497 details
CAV1_HUMANPP1A_HUMANBioGRID14645548 details
CAV1_HUMANPP2AA_HUMANBioGRID14645548 17855368 details
CAV1_HUMANSYUA_HUMANBioGRID21693152 details
CAV1_HUMANPTGIS_HUMANBioGRID11339822 details
CAV1_HUMANPPARG_HUMANBioGRID12813462 21690289 details
CAV1_HUMANLATS1_HUMANBioGRID24107629 34079125 details
CAV1_HUMANTIE2_HUMANBioGRID28760776 details
CAV1_HUMANGLP1R_HUMANBioGRID25044020 details
CAV1_HUMANTRAF2_HUMANBioGRID, HPRD, MINT11112773 11805080 32041822 details
CAV1_HUMANMDR1_HUMANBioGRID, HPRD, MINT10682831 15498565 details
CAV1_HUMANCAV2_HUMANBioGRID, DIP, HPRD, IntAct10212252 12414992 18081315 24013648 31980649 9361015 details
CAV1_HUMANFLOT1_HUMANBioGRID, IntAct10212252 22936677 25204797 34079125 details
CAV1_HUMANFLOT2_HUMANBioGRID, HPRD, IntAct10212252 34079125 details
CAV1_HUMANIGHA1_HUMANIntAct17353931 details
CAV1_HUMANUBC12_HUMANIntAct17353931 details
CAV1_HUMANPO3F3_HUMANIntAct17353931 details
CAV1_HUMANPED1A_HUMANIntAct17353931 details
CAV1_HUMANIGKC_HUMANIntAct17353931 details
CAV1_HUMANRADIL_HUMANIntAct17353931 details
CAV1_HUMANNEDD8_HUMANIntAct17353931 details
CAV1_HUMANDMBT1_HUMANIntAct17353931 details
CAV1_HUMANPTEN_HUMANBioGRID, HPRD, MINT12176037 details
CAV1_HUMANPTN6_HUMANBioGRID, HPRD, MINT12176037 details
CAV1_HUMANPTPRF_HUMANBioGRID, HPRD, MINT12176037 34079125 details
CAV1_HUMANCAVN3_HUMANDIP, MINT19262564 24013648 details
CAV1_HUMANCAVN2_HUMANDIP, MINT19262564 24013648 details
CAV1_HUMANBIP_HUMANIntAct19632185 details
CAV1_HUMANSCRB1_HUMANBioGRID, MINT14570588 34079125 details
CAV1_HUMANPAR1_HUMANBioGRID, UniProt17848177 20826780 details
CAV1_HUMANBID_HUMANBioGRID, IntAct21382479 details
CAV1_HUMANTNR6_HUMANBioGRID, DIP, IntAct20956295 21382479 details
CAV1_HUMANMCL1_HUMANBioGRID, IntAct22277751 details
CAV1_HUMANLRP6_HUMANbhf-ucl, BioGRID16890161 28966723 34079125 details
CAV1_HUMANSMAD4_HUMANMINT24211445 details
CAV1_HUMANCTNB1_HUMANbhf-ucl, BioGRID18356165 19244345 details
CAV1_HUMANHDAC6_HUMANbhf-ucl, BioGRID18356165 details
CAV1_HUMANNCF1_HUMANIntAct21659644 details
CAV1_HUMANGCR_HUMANIntAct23339905 details
CAV1_HUMANNPC1_HUMANIntAct25285302 details
CAV1_HUMANNOS3_HUMANBioGRID, DIP, HPRD11425855 12852865 17502619 8910295 details
CAV1_HUMANACTB_HUMANBioGRID, DIP17502619 28734243 details
CAV1_HUMANRB27B_HUMANDIP19706440 details
CAV1_HUMANKAP2_HUMANDIP19706440 details
CAV1_HUMANMYRIP_HUMANDIP19706440 details
CAV1_HUMANMLP3B_HUMANDIP20956295 details
CAV1_HUMANCAVN1_HUMANBioGRID, DIP, IntAct19726876 22939629 24013648 34079125 details
CAV1_HUMANASM3B_HUMANIntAct31217420 details
CAV1_HUMANINSR_HUMANBioGRID, HPRD, IntAct10598578 31217420 details
CAV1_HUMANSTK38_HUMANBioGRID, IntAct31980649 details
CAV1_HUMANPLD2_HUMANBioGRID, HPRD10675563 14675200 details
CAV1_HUMANAQP3_HUMANBioGRID14675200 details
CAV1_HUMANBTK_HUMANBioGRID, HPRD11751885 details
CAV1_HUMANBMX_HUMANBioGRID, HPRD11751885 details
CAV1_HUMANTRADD_HUMANBioGRID11112773 details
CAV1_HUMANTNR1B_HUMANBioGRID, HPRD11112773 details
CAV1_HUMANNTRK1_HUMANBioGRID, HPRD9867838 details
CAV1_HUMANNEUR3_HUMANBioGRID, HPRD12011038 details
CAV1_HUMANTSC2_HUMANBioGRID12147258 details
CAV1_HUMANKAPCA_HUMANBioGRID11546661 details
CAV1_HUMANS1PR1_HUMANBioGRID, HPRD10921915 details
CAV1_HUMANRECO_HUMANBioGRID, HPRD12507501 details
CAV1_HUMANTGFR1_HUMANBioGRID, HPRD11102446 30745168 details
CAV1_HUMANSMAD2_HUMANBioGRID11102446 details
CAV1_HUMANCXB2_HUMANBioGRID, HPRD11980479 details
CAV1_HUMANCXB1_HUMANBioGRID11980479 details
CAV1_HUMANTNR1A_HUMANBioGRID12753742 details
CAV1_HUMANTNFA_HUMANBioGRID12753742 details
CAV1_HUMANNKD2_HUMANBioGRID20177058 details
CAV1_HUMANMK03_HUMANBioGRID, HPRD12388423 details
CAV1_HUMANMK01_HUMANBioGRID, HPRD12388423 details
CAV1_HUMANPLAP_HUMANBioGRID22484374 details
CAV1_HUMANPDIA3_HUMANBioGRID22484374 details
CAV1_HUMANCD44_HUMANBioGRID21701559 details
CAV1_HUMANCXCR4_HUMANBioGRID22275353 details
CAV1_HUMANITCH_HUMANBioGRID22275353 details
CAV1_HUMANTOLIP_HUMANBioGRID16107720 details
CAV1_HUMANIRAK1_HUMANBioGRID16107720 details
CAV1_HUMANFYN_HUMANBioGRID, HPRD12529448 19432816 9252391 details
CAV1_HUMANKCNA5_HUMANBioGRID18218624 26931497 27075359 details
CAV1_HUMAN2AAA_HUMANBioGRID14645548 details
CAV1_HUMAN2AAB_HUMANBioGRID14645548 details
CAV1_HUMANPTPA_HUMANBioGRID14645548 details
CAV1_HUMANVDAC1_HUMANBioGRID19595769 31980649 details
CAV1_HUMANSQSTM_HUMANBioGRID23333919 28734243 34079125 details
CAV1_HUMANUBXN6_HUMANBioGRID23335559 details
CAV1_HUMANKCNN3_HUMANBioGRID22952906 details
CAV1_HUMANITPR3_HUMANBioGRID19052258 details
CAV1_HUMANPTC1_HUMANBioGRID11278759 details
CAV1_HUMANTNS2_HUMANBioGRID16951145 details
CAV1_HUMANRHG07_HUMANBioGRID16951145 22693251 details
CAV1_HUMANMLC1_HUMANBioGRID19931615 details
CAV1_HUMANNF1_HUMANBioGRID16405917 details
CAV1_HUMANMALL_HUMANBioGRID, HPRD11294831 1294831 details
CAV1_HUMANKCMA1_HUMANBioGRID15703204 details
CAV1_HUMANBMPR2_HUMANBioGRID15657086 details
CAV1_HUMANBMR1A_HUMANBioGRID15657086 details
CAV1_HUMANAXIN1_HUMANBioGRID16890161 details
CAV1_HUMANHS90A_HUMANBioGRID17502619 details
CAV1_HUMANGAPR1_HUMANBioGRID11865038 details
CAV1_HUMANVGFR2_HUMANBioGRID, HPRD12529448 23262137 details
CAV1_HUMANATP4A_HUMANBioGRID17255364 details
CAV1_HUMANDERL1_HUMANBioGRID24089527 details
CAV1_HUMANSELS_HUMANBioGRID24089527 details
CAV1_HUMANUFD1_HUMANBioGRID24089527 details
CAV1_HUMANPGH1_HUMANBioGRID15230350 details
CAV1_HUMANATG5_HUMANBioGRID24727585 details
CAV1_HUMANATG12_HUMANBioGRID24727585 details
CAV1_HUMANMRP1_HUMANBioGRID14627714 34079125 details
CAV1_HUMANTFR1_HUMANBioGRID14627714 34079125 details
CAV1_HUMANK2C8_HUMANBioGRID20808760 details
CAV1_HUMANSEPR_HUMANBioGRID26209915 details
CAV1_HUMANAN13A_HUMANBioGRID26797118 details
CAV1_HUMANADCY6_HUMANBioGRID21228062 details
CAV1_HUMANADCY5_HUMANBioGRID21228062 details
CAV1_HUMANTLR4_HUMANBioGRID21715681 details
CAV1_HUMANMCR_HUMANBioGRID28734243 details
CAV1_HUMANUBC_HUMANBioGRID28734243 details
CAV1_HUMANMLP3A_HUMANBioGRID28734243 details
CAV1_HUMANCUL3_HUMANBioGRID28499918 details
CAV1_HUMANFAS_HUMANBioGRID18635971 details
CAV1_HUMANMMP14_HUMANBioGRID, HPRD15466865 details
CAV1_HUMANTGFR2_HUMANBioGRID30745168 details
CAV1_HUMANPSDE_HUMANBioGRID30745168 details
CAV1_HUMANTR10B_HUMANBioGRID19432816 details
CAV1_HUMANCAV1_HUMANBioGRID, HPRD11114180 31980649 details
CAV1_HUMANISG15_HUMANBioGRID33024031 details
CAV1_HUMANBASI_HUMANBioGRID, HPRD15201341 34079125 details
CAV1_HUMANERBB2_HUMANBioGRID, HPRD34079125 9685399 details
CAV1_HUMANPRIO_HUMANHPRD10988071 details
CAV1_HUMANFLNA_HUMANHPRD10637311 details
CAV1_HUMANBST1_HUMANHPRD11866528 details
CAV1_HUMANAKAP1_HUMANHPRD11546661 details
CAV1_HUMANSTML3_HUMANHPRD12122055 details
CAV1_HUMANSTRN_HUMANHPRD11707266 details
CAV1_HUMANSTRN4_HUMANHPRD11707266 details
CAV1_HUMANCSK21_HUMANHPRD8058322 details
CAV1_HUMANCSK22_HUMANHPRD8058322 details
CAV1_HUMANILK_HUMANHPRD15722199 details
CAV1_HUMANTNR5_HUMANHPRD14665433 details
CAV1_HUMAN5HT1F_HUMANHPRD15190056 details
CAV1_HUMANSOS1_HUMANHPRD15976327 details
CAV1_HUMANLRP1_HUMANHPRD14593097 details
CAV1_HUMANIBP3_HUMANHPRD14576164 details
CAV1_HUMANIRS1_HUMANHPRD15003536 details
CAV1_HUMANCXA3_HUMANHPRD11980479 details
CAV1_HUMANGRB7_HUMANHPRD11075810 details
CAV1_HUMANTRAF6_HUMANHPRD14665433 details
CAV1_HUMANDYN1_HUMANHPRD11956154 details
CAV1_HUMANPLD1_HUMANHPRD10090765 12429840 details
CAV1_HUMANIGF1R_HUMANHPRD18632619 details
CAV1_HUMANGNAI2_HUMANHPRD8621645 details