Entity Details

Primary name KPCD_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ05655
EntryNameKPCD_HUMAN
FullNameProtein kinase C delta type
TaxID9606
Evidenceevidence at protein level
Length676
SequenceStatuscomplete
DateCreated1994-06-01
DateModified2021-06-02

Ontological Relatives

GenesPRKCD

GO terms

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GOName
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004697 protein kinase C activity
GO:0004698 calcium-dependent protein kinase C activity
GO:0004699 calcium-independent protein kinase C activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0007165 signal transduction
GO:0008047 enzyme activator activity
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010469 regulation of signaling receptor activity
GO:0016064 immunoglobulin mediated immune response
GO:0016363 nuclear matrix
GO:0016572 histone phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0019901 protein kinase binding
GO:0023021 termination of signal transduction
GO:0030168 platelet activation
GO:0030837 negative regulation of actin filament polymerization
GO:0032079 positive regulation of endodeoxyribonuclease activity
GO:0032091 negative regulation of protein binding
GO:0032147 activation of protein kinase activity
GO:0032930 positive regulation of superoxide anion generation
GO:0032956 regulation of actin cytoskeleton organization
GO:0034351 negative regulation of glial cell apoptotic process
GO:0034644 cellular response to UV
GO:0035307 positive regulation of protein dephosphorylation
GO:0035556 intracellular signal transduction
GO:0035578 azurophil granule lumen
GO:0036019 endolysosome
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042100 B cell proliferation
GO:0042119 neutrophil activation
GO:0042307 positive regulation of protein import into nucleus
GO:0042742 defense response to bacterium
GO:0043312 neutrophil degranulation
GO:0043407 negative regulation of MAP kinase activity
GO:0043488 regulation of mRNA stability
GO:0043560 insulin receptor substrate binding
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046872 metal ion binding
GO:0048471 perinuclear region of cytoplasm
GO:0050728 negative regulation of inflammatory response
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0050821 protein stabilization
GO:0051490 negative regulation of filopodium assembly
GO:0060326 cell chemotaxis
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0070062 extracellular exosome
GO:0070301 cellular response to hydrogen peroxide
GO:0071447 cellular response to hydroperoxide
GO:0090331 negative regulation of platelet aggregation
GO:0090398 cellular senescence
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900163 positive regulation of phospholipid scramblase activity
GO:1904385 cellular response to angiotensin
GO:2000303 regulation of ceramide biosynthetic process
GO:2000304 positive regulation of ceramide biosynthetic process
GO:2000753 positive regulation of glucosylceramide catabolic process
GO:2000755 positive regulation of sphingomyelin catabolic process
GO:2001022 positive regulation of response to DNA damage stimulus
GO:2001235 positive regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Endomembrane system
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR014376 Protein kinase C, delta/epsilon/eta/theta typesFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR017892 Protein kinase, C-terminalDomainDomain
IPR020454 Diacylglycerol/phorbol-ester bindingDomainDomain
IPR027436 Protein kinase C, deltaFamilyFamily
IPR034667 Novel protein kinase C delta, catalytic domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00675 TamoxifenDrugbanksmall molecule
DB04376 13-AcetylphorbolDrugbanksmall molecule
DB05013 Ingenol mebutateDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

149 interactions

InteractorPartnerSourcesPublicationsLink
KPCD_HUMANFYN_HUMANBioGRID, HPRD, IntAct10383400 12721299 25241761 8621384 details
KPCD_HUMANNCF1_HUMANBioGRID, HPRD, MINT11145703 12056906 17069809 8089108 details
KPCD_HUMANNEUM_HUMANHPRD, IntAct9139733 details
KPCD_HUMANKPCD_HUMANBioGRID, HPRD, MINT11352632 11839738 12097319 17603046 18285462 9305920 details
KPCD_HUMANSHC1_HUMANBioGRID, HPRD, IntAct12024011 19380743 31980649 details
KPCD_HUMANP53_HUMANBioGRID, IntAct16314418 16377624 17938203 details
KPCD_HUMANC1QBP_HUMANBioGRID, HPRD, UniProt10831594 details
KPCD_HUMANTOP2A_HUMANIntAct16611985 details
KPCD_HUMANNCF2_HUMANIntAct15591124 details
KPCD_HUMANPTN22_HUMANDIP, HPRD18056643 details
KPCD_HUMANVPS29_HUMANIntAct32814053 details
KPCD_HUMANA4_HUMANBioGRID, IntAct21832049 32814053 details
KPCD_HUMANGRP3_HUMANBioGRID, HPRD15213298 details
KPCD_HUMANPLS3_HUMANBioGRID, HPRD12649167 details
KPCD_HUMANPDPK1_HUMANBioGRID, HPRD11381116 11781095 9748166 details
KPCD_HUMANGNA12_HUMANBioGRID8824244 details
KPCD_HUMANGNA13_HUMANBioGRID, HPRD8824244 details
KPCD_HUMANSTAT1_HUMANBioGRID, HPRD11839738 11972023 12637327 12807916 12817007 14963018 15322115 19553685 7543024 7690989 9355737 details
KPCD_HUMANPP2AA_HUMANBioGRID, HPRD11959144 details
KPCD_HUMANIRS1_HUMANBioGRID, HPRD12031982 15364919 15516986 details
KPCD_HUMANPTN6_HUMANBioGRID, HPRD11723252 details
KPCD_HUMANTIAM1_HUMANBioGRID, HPRD10212259 details
KPCD_HUMANPLD2_HUMANBioGRID, HPRD11744693 details
KPCD_HUMANAFAP1_HUMANBioGRID, HPRD12134071 details
KPCD_HUMANMUC1_HUMANBioGRID, HPRD11877440 details
KPCD_HUMANIKKA_HUMANBioGRID10022904 details
KPCD_HUMANIKKB_HUMANBioGRID10022904 details
KPCD_HUMANSP1_HUMANBioGRID19169273 21159880 22496486 details
KPCD_HUMANHDAC5_HUMANBioGRID21146494 details
KPCD_HUMANSTAT3_HUMANBioGRID, HPRD10446219 10521505 11335711 11350938 12576423 12763138 14551213 9343414 9872331 details
KPCD_HUMANVHL_HUMANBioGRID16669786 29050245 details
KPCD_HUMANH11_HUMANBioGRID12056906 16314418 details
KPCD_HUMANH15_HUMANBioGRID11839738 15978696 details
KPCD_HUMANITB2_HUMANBioGRID, HPRD11700305 details
KPCD_HUMANTNR1A_HUMANBioGRID11078718 details
KPCD_HUMANGSK3A_HUMANBioGRID, HPRD11035810 11749387 11884598 12054501 details
KPCD_HUMANELAV1_HUMANBioGRID17392515 18285462 20086103 21310943 details
KPCD_HUMANSQSTM_HUMANBioGRID20974803 28846113 details
KPCD_HUMANDYHC1_HUMANBioGRID20395553 details
KPCD_HUMANHSP74_HUMANBioGRID20395553 details
KPCD_HUMANHS90A_HUMANBioGRID, HPRD19356729 20395553 details
KPCD_HUMANITPR1_HUMANBioGRID20395553 details
KPCD_HUMANMACF1_HUMANBioGRID20395553 details
KPCD_HUMANNAR3_HUMANBioGRID20395553 details
KPCD_HUMANTERA_HUMANBioGRID20395553 details
KPCD_HUMANEP300_HUMANBioGRID, HPRD11020388 12379484 details
KPCD_HUMANFLI1_HUMANBioGRID19158279 details
KPCD_HUMANDAB2_HUMANBioGRID, HPRD10542228 details
KPCD_HUMANNOTC1_HUMANBioGRID24662486 details
KPCD_HUMANP73_HUMANBioGRID12097319 15723830 details
KPCD_HUMANMBP_HUMANBioGRID, HPRD11964256 12097319 details
KPCD_HUMANSPY2_HUMANBioGRID19458088 details
KPCD_HUMANCDCP1_HUMANHPRD, I2D, MINT15851033 21725358 details
KPCD_HUMANSRC_HUMANHPRD, MINT15337529 15851033 details
KPCD_HUMANABL1_HUMANMINT16631755 details
KPCD_HUMANTROP_HUMANBioGRID, UniProt21191175 details
KPCD_HUMANDBLOH_HUMANBioGRID, MINT22465666 details
KPCD_HUMANGRM5_HUMANBioGRID, HPRD, IntAct15894802 25241761 details
KPCD_HUMANIL32_HUMANBioGRID, IntAct, MINT23814099 24396867 25178676 29050245 details
KPCD_HUMANSPI1_HUMANMINT24996056 details
KPCD_HUMANPRKDC_HUMANHPRD, IntAct16611985 9774685 details
KPCD_HUMANT53I1_HUMANIntAct16377624 details
KPCD_HUMANP63_HUMANMINT26112605 details
KPCD_HUMANCAR11_HUMANBioGRID, IntAct22528498 details
KPCD_HUMANMALT1_HUMANBioGRID, IntAct22528498 details
KPCD_HUMANTRAF6_HUMANBioGRID, IntAct22528498 details
KPCD_HUMANSHIP1_HUMANBioGRID12024011 details
KPCD_HUMAN1433G_HUMANBioGRID, HPRD10433554 details
KPCD_HUMANMTOR_HUMANBioGRID10698949 details
KPCD_HUMANFAK2_HUMANBioGRID, HPRD11352632 details
KPCD_HUMANADAM9_HUMANBioGRID, HPRD9857183 details
KPCD_HUMANINSR_HUMANBioGRID, HPRD11266508 12031982 details
KPCD_HUMANPDP1_HUMANBioGRID, HPRD11577086 details
KPCD_HUMANPDP2_HUMANBioGRID, HPRD11577086 details
KPCD_HUMANPK3CB_HUMANBioGRID, HPRD11676480 details
KPCD_HUMAN1433Z_HUMANBioGRID, HPRD11950841 9705322 details
KPCD_HUMANIL6RB_HUMANBioGRID, HPRD12361954 details
KPCD_HUMANGBRA1_HUMANBioGRID, HPRD12091471 details
KPCD_HUMANTRI41_HUMANBioGRID17893151 details
KPCD_HUMANHSPB1_HUMANBioGRID15731106 details
KPCD_HUMANKLF4_HUMANBioGRID22282354 details
KPCD_HUMANIBTK_HUMANBioGRID21482705 details
KPCD_HUMANIRAK1_HUMANBioGRID21804018 details
KPCD_HUMANSYUA_HUMANBioGRID15978696 details
KPCD_HUMANPHB_HUMANBioGRID19725029 details
KPCD_HUMANRBP10_HUMANBioGRID20395553 details
KPCD_HUMANRANB9_HUMANBioGRID20395553 details
KPCD_HUMANATG7_HUMANBioGRID30589566 30690837 details
KPCD_HUMANLYN_HUMANHPRD10945993 7575560 details
KPCD_HUMANOPRD_HUMANHPRD11085981 details
KPCD_HUMANPK3CA_HUMANHPRD11676480 details
KPCD_HUMANPTPRA_HUMANHPRD11676480 11923305 details
KPCD_HUMANKPCZ_HUMANHPRD11381116 12162751 details
KPCD_HUMANCYH1_HUMANHPRD11438522 details
KPCD_HUMANCBP_HUMANHPRD11463380 details
KPCD_HUMANMEP1B_HUMANHPRD12941954 details
KPCD_HUMANNF2L2_HUMANHPRD12198130 details
KPCD_HUMANKCNJ4_HUMANHPRD10206975 11713246 details
KPCD_HUMANHNRPK_HUMANHPRD10329716 details
KPCD_HUMANTAGL_HUMANHPRD11053353 details
KPCD_HUMANNCF4_HUMANHPRD9804763 details
KPCD_HUMAN2A5G_HUMANHPRD11959144 details
KPCD_HUMANFSCN1_HUMANHPRD8647875 8999969 details
KPCD_HUMANKLF5_HUMANHPRD12682370 details
KPCD_HUMANIF2A_HUMANHPRD10542257 11555640 1677563 9819435 details
KPCD_HUMANPLCB1_HUMANHPRD11278470 details
KPCD_HUMANAKT3_HUMANHPRD12162751 details
KPCD_HUMANPEBP1_HUMANHPRD12551925 14654844 details
KPCD_HUMANPLS1_HUMANHPRD10770950 details
KPCD_HUMANKCNJ1_HUMANHPRD8621594 details
KPCD_HUMANHABP4_HUMANHPRD14699138 details
KPCD_HUMANPP1A_HUMANHPRD11959144 details
KPCD_HUMANPPM1A_HUMANHPRD11959144 details
KPCD_HUMAN1433B_HUMANHPRD16024783 details
KPCD_HUMANRUNX2_HUMANHPRD16421932 details
KPCD_HUMANARBK1_HUMANHPRD11042191 details
KPCD_HUMANADRB2_HUMANHPRD1848190 details
KPCD_HUMANBKRB2_HUMANHPRD11517230 details
KPCD_HUMANRACK1_HUMANHPRD11884618 details
KPCD_HUMANIGF1R_HUMANHPRD11884618 details
KPCD_HUMANCLAT_HUMANHPRD15381704 details
KPCD_HUMANADCY7_HUMANHPRD12454008 details
KPCD_HUMANSDC4_HUMANHPRD11916978 details
KPCD_HUMANACTS_HUMANHPRD11415434 details
KPCD_HUMANMK03_HUMANHPRD12759139 details
KPCD_HUMANMK01_HUMANHPRD12759139 details
KPCD_HUMANPAK1_HUMANHPRD16033904 details
KPCD_HUMANRAF1_HUMANHPRD11171046 details
KPCD_HUMANCN37_HUMANHPRD10646504 details
KPCD_HUMANERR1_HUMANHPRD16024613 details
KPCD_HUMANACTA_HUMANHPRD10628374 details
KPCD_HUMANACTB_HUMANHPRD11415434 details
KPCD_HUMANEF1A1_HUMANHPRD7890750 details
KPCD_HUMANNUMB_HUMANHPRD17203073 details
KPCD_HUMANFCERB_HUMANHPRD19356729 details
KPCD_HUMANRAC1_HUMANHPRD19356729 details
KPCD_HUMANEGFR_HUMANHPRD2984676 2987962 details
KPCD_HUMANADDA_HUMANHPRD8810272 9679146 details
KPCD_HUMANADDB_HUMANHPRD8810272 9679146 details
KPCD_HUMANGNAZ_HUMANHPRD7559455 8429024 9166747 details
KPCD_HUMANCD34_HUMANHPRD1694174 details
KPCD_HUMANADA2A_HUMANHPRD11732925 details
KPCD_HUMANITA6_HUMANHPRD11389095 details
KPCD_HUMANITB4_HUMANHPRD11389095 details
KPCD_HUMANITB7_HUMANHPRD12682249 details
KPCD_HUMANLMNB1_HUMANHPRD11901153 details
KPCD_HUMANLMNB2_HUMANHPRD1939065 details
KPCD_HUMANLCK_HUMANHPRD11381116 details
KPCD_HUMANTAU_HUMANHPRD10090741 10737616 12387894 12435421 7706316 8999860 9735171 9771888 9832145 details