Entity Details

Primary name ZO1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ07157
EntryNameZO1_HUMAN
FullNameTight junction protein ZO-1
TaxID9606
Evidenceevidence at protein level
Length1748
SequenceStatuscomplete
DateCreated1994-10-01
DateModified2021-06-02

Ontological Relatives

GenesTJP1

GO terms

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GOName
GO:0002102 podosome
GO:0005516 calmodulin binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0005921 gap junction
GO:0005923 bicellular tight junction
GO:0007043 cell-cell junction assembly
GO:0008284 positive regulation of cell population proliferation
GO:0016323 basolateral plasma membrane
GO:0030054 cell junction
GO:0030335 positive regulation of cell migration
GO:0031032 actomyosin structure organization
GO:0032991 protein-containing complex
GO:0034334 adherens junction maintenance
GO:0035329 hippo signaling
GO:0035633 maintenance of blood-brain barrier
GO:0042995 cell projection
GO:0043066 negative regulation of apoptotic process
GO:0043296 apical junction complex
GO:0045177 apical part of cell
GO:0045216 cell-cell junction organization
GO:0045296 cadherin binding
GO:0050839 cell adhesion molecule binding
GO:0051493 regulation of cytoskeleton organization
GO:0051497 negative regulation of stress fiber assembly
GO:0070160 tight junction
GO:0071896 protein localization to adherens junction
GO:0090557 establishment of endothelial intestinal barrier
GO:0098609 cell-cell adhesion
GO:0150105 protein localization to cell-cell junction
GO:1901888 regulation of cell junction assembly
GO:1902396 protein localization to bicellular tight junction
GO:1903672 positive regulation of sprouting angiogenesis
GO:1905605 positive regulation of blood-brain barrier permeability
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin
GO:2000250 negative regulation of actin cytoskeleton reorganization
GO:2000810 regulation of bicellular tight junction assembly

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Cell projection

Domains

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DomainNameCategoryType
IPR000906 ZU5 domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR001478 PDZ domainDomainDomain
IPR005417 Tight junction protein ZOFamilyFamily
IPR005418 Tight junction protein ZO-1FamilyFamily
IPR008144 Guanylate kinase-like domainDomainDomain
IPR008145 Guanylate kinase/L-type calcium channel beta subunitDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR035597 ZO-1, SH3 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036034 PDZ superfamilyFamilyHomologous superfamily

Diseases

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Interactions

62 interactions

InteractorPartnerSourcesPublicationsLink
ZO1_HUMANCING_HUMANBioGRID, HPRD, IntAct, UniProt10613913 11042084 12023291 28514442 34079125 details
ZO1_HUMANCXA1_HUMANBioGRID, HPRD, IntAct, MINT16944923 9707407 details
ZO1_HUMANCXD3_HUMANBioGRID, IntAct12154091 details
ZO1_HUMANOCLN_HUMANBioGRID, HPRD, Molecular Connections10575001 10601346 11700038 12169098 18662404 19017651 23758859 26090670 33100129 34079125 7798316 9792688 details
ZO1_HUMANKIRR1_HUMANBioGRID, HPRD, IntAct12578837 12865409 22262837 details
ZO1_HUMANAFAD_HUMANBioGRID, IntAct10334923 23750010 34079125 details
ZO1_HUMANZO2_HUMANBioGRID, HPRD, IntAct10026224 10575001 10966866 24255178 26344197 34079125 7542259 9792688 details
ZO1_HUMANCLD2_HUMANBioGRID, HPRD, IntAct10601346 22546605 details
ZO1_HUMANJAM1_HUMANBioGRID10856295 12953056 details
ZO1_HUMANJAM2_HUMANBioGRID, HPRD12953056 details
ZO1_HUMANJAM3_HUMANBioGRID, HPRD12953056 details
ZO1_HUMANCXA8_HUMANBioGRID, HPRD12808044 details
ZO1_HUMANCXA3_HUMANBioGRID, HPRD12808044 details
ZO1_HUMANCLD1_HUMANBioGRID, HPRD10601346 details
ZO1_HUMANCLD3_HUMANBioGRID, HPRD10601346 details
ZO1_HUMANCLD4_HUMANBioGRID, HPRD10601346 details
ZO1_HUMANCLD5_HUMANBioGRID, HPRD10601346 details
ZO1_HUMANCLD6_HUMANBioGRID, HPRD10601346 details
ZO1_HUMANCLD7_HUMANBioGRID, HPRD10601346 details
ZO1_HUMANCLD8_HUMANBioGRID, HPRD10601346 31262043 details
ZO1_HUMANHS90A_HUMANBioGRID18591668 details
ZO1_HUMANYBOX3_HUMANBioGRID16508013 details
ZO1_HUMANKHDR1_HUMANBioGRID22745667 details
ZO1_HUMANPEA15_HUMANBioGRID24710276 details
ZO1_HUMANARVC_HUMANHPRD15456900 details
ZO1_HUMANMAGI3_HUMANMINT10748157 details
ZO1_HUMANACTN4_HUMANBioGRID, HPRD, IntAct16944923 details
ZO1_HUMANPVR_HUMANMINT17717529 details
ZO1_HUMANWWTR1_HUMANMINT20850437 details
ZO1_HUMANMRCKB_HUMANMINT21240187 details
ZO1_HUMANVMP1_HUMANBioGRID, UniProt17724469 details
ZO1_HUMANTACD2_HUMANIntAct20651236 details
ZO1_HUMANPTN14_HUMANBioGRID, HPRD12808048 details
ZO1_HUMANEGFR_HUMANBioGRID, HPRD12708492 details
ZO1_HUMANRAB8B_HUMANBioGRID12639940 details
ZO1_HUMANZO3_HUMANBioGRID10575001 details
ZO1_HUMANACTN1_HUMANBioGRID16944923 details
ZO1_HUMANK2C1_HUMANBioGRID16944923 details
ZO1_HUMANPAR6A_HUMANBioGRID11257119 details
ZO1_HUMANKPCI_HUMANBioGRID11257119 details
ZO1_HUMANPARD3_HUMANBioGRID11257119 34079125 details
ZO1_HUMANSTRN_HUMANBioGRID18502210 details
ZO1_HUMANDTNA_HUMANBioGRID15834686 details
ZO1_HUMANRN168_HUMANBioGRID27558965 details
ZO1_HUMANCAN5_HUMANBioGRID30024968 details
ZO1_HUMANCBLB_HUMANBioGRID30024968 details
ZO1_HUMANPSA5_HUMANBioGRID31262043 details
ZO1_HUMANMIB1_HUMANBioGRID31462741 details
ZO1_HUMANATG5_HUMANBioGRID33024031 details
ZO1_HUMANISG15_HUMANBioGRID33024031 details
ZO1_HUMANMALD2_HUMANBioGRID33100129 details
ZO1_HUMANCTNA1_HUMANBioGRID, HPRD34079125 9214391 details
ZO1_HUMANZO1_HUMANHPRD10026224 10966866 details
ZO1_HUMANNMDE4_HUMANHPRD10862698 details
ZO1_HUMANCXB3_HUMANHPRD12154091 details
ZO1_HUMANCXG1_HUMANHPRD11557048 12064590 details
ZO1_HUMANNMDZ1_HUMANHPRD10862698 details
ZO1_HUMANTRPC4_HUMANHPRD15540229 details
ZO1_HUMANCLD16_HUMANHPRD14628289 details
ZO1_HUMANACTS_HUMANHPRD9214391 details
ZO1_HUMANCNKR2_HUMANHPRD16637659 details
ZO1_HUMANSRC8_HUMANHPRD11018051 9792678 details