Entity Details

Primary name MERTK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ12866
EntryNameMERTK_HUMAN
FullNameTyrosine-protein kinase Mer
TaxID9606
Evidenceevidence at protein level
Length999
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesMERTK

GO terms

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GOName
GO:0001750 photoreceptor outer segment
GO:0001779 natural killer cell differentiation
GO:0001818 negative regulation of cytokine production
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006468 protein phosphorylation
GO:0006909 phagocytosis
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development
GO:0007283 spermatogenesis
GO:0007399 nervous system development
GO:0016028 rhabdomere
GO:0016477 cell migration
GO:0030168 platelet activation
GO:0032940 secretion by cell
GO:0033674 positive regulation of kinase activity
GO:0034446 substrate adhesion-dependent cell spreading
GO:0043235 receptor complex
GO:0043491 protein kinase B signaling
GO:0050766 positive regulation of phagocytosis
GO:0050900 leukocyte migration
GO:0051250 negative regulation of lymphocyte activation
GO:0060041 retina development in camera-type eye
GO:0060068 vagina development
GO:0097350 neutrophil clearance
GO:2000107 negative regulation of leukocyte apoptotic process

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR003961 Fibronectin type IIIDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013151 ImmunoglobulinDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036116 Fibronectin type III superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB08325 2-({6-[(3-Chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)ethanolDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule