Entity Details

Primary name RIPK3
Entity type gene
Source Source Link

Details

PrimaryID11035
RefseqGeneNG_046975
SymbolRIPK3
Namereceptor interacting serine/threonine kinase 3
Chromosome14
Location14q12
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-12-17
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsRIPK3_HUMAN

GO terms

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GOName
GO:0001914 regulation of T cell mediated cytotoxicity
GO:0002819 regulation of adaptive immune response
GO:0003713 transcription coactivator activity
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004704 NF-kappaB-inducing kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006464 cellular protein modification process
GO:0007165 signal transduction
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0010922 positive regulation of phosphatase activity
GO:0019054 modulation by virus of host cellular process
GO:0032147 activation of protein kinase activity
GO:0032649 regulation of interferon-gamma production
GO:0032991 protein-containing complex
GO:0033077 T cell differentiation in thymus
GO:0042802 identical protein binding
GO:0042981 regulation of apoptotic process
GO:0043029 T cell homeostasis
GO:0044877 protein-containing complex binding
GO:0046006 regulation of activated T cell proliferation
GO:0046777 protein autophosphorylation
GO:0048535 lymph node development
GO:0048536 spleen development
GO:0048538 thymus development
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051351 positive regulation of ligase activity
GO:0051353 positive regulation of oxidoreductase activity
GO:0051607 defense response to virus
GO:0060544 regulation of necroptotic process
GO:0060545 positive regulation of necroptotic process
GO:0062099 negative regulation of programmed necrotic cell death
GO:0070235 regulation of activation-induced cell death of T cells
GO:0070266 necroptotic process
GO:0070301 cellular response to hydrogen peroxide
GO:0097190 apoptotic signaling pathway
GO:0097300 programmed necrotic cell death
GO:0097527 necroptotic signaling pathway
GO:0097528 execution phase of necroptosis
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1990000 amyloid fibril formation
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000452 regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Diseases

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Interactions

125 interactions

InteractorPartnerSourcesPublicationsLink
RIPK3RIPK3BioGRID, IntAct14743216 22817896 27045108 details
RIPK3RIPK1BioGRID, HPIDb, HPRD, IntAct10339433 19524512 19524513 21903422 22265413 22265414 22817896 22864571 23744296 24098568 25882049 26319693 26559832 26786097 29352166 29497034 29883609 30420664 31358971 details
RIPK3RFX6BioGRID, IntAct21988832 details
RIPK3BIRC3BioGRID, IntAct21931591 details
RIPK3XIAPBioGRID, IntAct21931591 details
RIPK3BIRC2BioGRID, IntAct21931591 details
RIPK3MLKLBioGRID, DIP, IntAct22265413 22265414 24316671 27560715 29883609 30420664 31358971 details
RIPK3TRAF2BioGRID, HPRD10339433 details
RIPK3DAXXBioGRID23260419 details
RIPK3SRPK2BioGRID26167880 details
RIPK3PELI1BioGRID29883609 details
RIPK3H1-5BioGRID29883609 details
RIPK3BUB1BBioGRID29883609 details
RIPK3UTP11BioGRID29883609 details
RIPK3TMEM44BioGRID29883609 details
RIPK3HELQBioGRID29883609 details
RIPK3TLE6BioGRID29883609 details
RIPK3HSPBAP1BioGRID29883609 details
RIPK3GBE1BioGRID29883609 details
RIPK3IL24BioGRID29883609 details
RIPK3ZSCAN20BioGRID29883609 details
RIPK3NME8BioGRID29883609 details
RIPK3AIFM1IntAct14743216 details
RIPK3YWHAEIntAct14743216 details
RIPK3PRDX1IntAct14743216 details
RIPK3SCINIntAct14743216 details
RIPK3HSPA1LIntAct14743216 details
RIPK3GNB2IntAct14743216 details
RIPK3HSPA5IntAct14743216 details
RIPK3DBN1IntAct14743216 details
RIPK3HSPA8IntAct14743216 details
RIPK3CAPZA1IntAct14743216 details
RIPK3SLC25A5IntAct14743216 details
RIPK3HSPA9IntAct14743216 details
RIPK3CORO1CIntAct14743216 details
RIPK3RUVBL2IntAct14743216 details
RIPK3IQGAP1IntAct14743216 details
RIPK3RPL23IntAct14743216 details
RIPK3MYO1CIntAct14743216 details
RIPK3CCT5IntAct14743216 details
RIPK3GNB4IntAct14743216 details
RIPK3CDC37BioGRID, IntAct14743216 21903422 details
RIPK3DNAJA1IntAct14743216 details
RIPK3EPRS1IntAct14743216 details
RIPK3HNRNPH1IntAct14743216 details
RIPK3ACTN4IntAct14743216 details
RIPK3MYO1BIntAct14743216 details
RIPK3C1QBPIntAct14743216 details
RIPK3EEF1A2IntAct14743216 details
RIPK3SPTAN1IntAct14743216 details
RIPK3TIAF1IntAct14743216 details
RIPK3DDX5IntAct14743216 details
RIPK3CCT7IntAct14743216 details
RIPK3WDR61IntAct14743216 details
RIPK3MYH10IntAct14743216 details
RIPK3CADIntAct14743216 details
RIPK3RUVBL1IntAct14743216 details
RIPK3ACTG1IntAct14743216 details
RIPK3SLC25A3IntAct14743216 details
RIPK3TIMM50IntAct14743216 details
RIPK3CLTCIntAct14743216 details
RIPK3GNB1IntAct14743216 details
RIPK3MYL6BIntAct14743216 details
RIPK3TUBB2BIntAct14743216 details
RIPK3HADHAIntAct14743216 details
RIPK3AIF1LIntAct14743216 details
RIPK3MYO6IntAct14743216 details
RIPK3CALM1IntAct14743216 details
RIPK3CALM2IntAct14743216 details
RIPK3CALM3IntAct14743216 details
RIPK3NONOIntAct14743216 details
RIPK3BASP1IntAct14743216 details
RIPK3TUBBIntAct14743216 details
RIPK3TUBB4AIntAct14743216 details
RIPK3ATAD3AIntAct14743216 details
RIPK3MPRIPIntAct14743216 details
RIPK3EEF1DIntAct14743216 details
RIPK3SPECC1LIntAct14743216 details
RIPK3TPM3IntAct14743216 details
RIPK3RAI14IntAct14743216 details
RIPK3PPP1R9BIntAct14743216 details
RIPK3FLNAIntAct14743216 details
RIPK3PPP1R12AIntAct14743216 details
RIPK3DAPK1IntAct14743216 details
RIPK3DDX3XIntAct14743216 details
RIPK3HNRNPA1IntAct14743216 details
RIPK3CCT2IntAct14743216 details
RIPK3TPM1IntAct14743216 details
RIPK3VIMIntAct14743216 details
RIPK3UBBIntAct14743216 details
RIPK3SPTBN1IntAct14743216 details
RIPK3HSP90AA1IntAct14743216 details
RIPK3PPP1CCIntAct14743216 details
RIPK3PPP1CBIntAct14743216 details
RIPK3PRKDCIntAct14743216 details
RIPK3MYL6IntAct14743216 details
RIPK3CAPZBIntAct14743216 details
RIPK3TUBA3DIntAct14743216 details
RIPK3TUBA3CIntAct14743216 details
RIPK3LIMA1IntAct14743216 details
RIPK3HSP90AB1IntAct14743216 details
RIPK3MYL12AIntAct14743216 details
RIPK3GNAI3IntAct14743216 details
RIPK3RPS27IntAct14743216 details
RIPK3GNG12IntAct14743216 details
RIPK3MYO1DIntAct14743216 details
RIPK3CASP8BioGRID, IntAct19524512 19524513 22864571 30420664 details
RIPK3FADDBioGRID, IntAct19524513 21052097 22864571 26786097 27560715 30420664 details
RIPK3ZBP1MINT19590578 details
RIPK3TICAM1BioGRID, HPRD15064760 details
RIPK3TNFRSF1ABioGRID, HPRD10339433 details
RIPK3PRKNBioGRID31358971 details
RIPK3PGAM5IntAct22265414 details
RIPK3EPHA4BioGRID, IntAct26186194 28514442 details
RIPK3AMY1AIntAct28514442 details
RIPK3AMY1BIntAct28514442 details
RIPK3AMY1CBioGRID, IntAct26186194 28514442 details
RIPK3CTNND1BioGRID21903422 details
RIPK3FKBP4BioGRID21903422 details
RIPK3FKBP5BioGRID21903422 details
RIPK3INPP5KBioGRID21903422 details
RIPK3PYGLBioGRID21903422 details
RIPK3STIP1BioGRID21903422 details
RIPK3ZG16BBioGRID26186194 details
RIPK3PTPRKBioGRID26186194 details