Entity Details

Primary name CHEK2
Entity type gene
Source Source Link

Details

PrimaryID11200
RefseqGeneNG_008150
SymbolCHEK2
Namecheckpoint kinase 2
Chromosome22
Location22q12.1
TaxID9606
Statuslive
SourceGenomegenomic
SourceOriginnatural
CreationDate1999-09-09
ModificationDate2021-06-22

Ontological Relatives

UniProt IDsCHK2_HUMAN

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000086 G2/M transition of mitotic cell cycle
GO:0001934 positive regulation of protein phosphorylation
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0006302 double-strand break repair
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0006975 DNA damage induced protein phosphorylation
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0016605 PML body
GO:0018105 peptidyl-serine phosphorylation
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0035690 cellular response to drug
GO:0042176 regulation of protein catabolic process
GO:0042770 signal transduction in response to DNA damage
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0044257 cellular protein catabolic process
GO:0044773 mitotic DNA damage checkpoint signaling
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0050821 protein stabilization
GO:0051301 cell division
GO:0071480 cellular response to gamma radiation
GO:0090307 mitotic spindle assembly
GO:0090399 replicative senescence
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1903416 response to glycoside
GO:1903926 cellular response to bisphenol A
GO:2000002 negative regulation of DNA damage checkpoint
GO:2000210 positive regulation of anoikis

Diseases

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Interactions

167 interactions

InteractorPartnerSourcesPublicationsLink
CHEK2CDC25ABioGRID, HPRD, MINT10724175 11298456 12676583 12759351 18480045 details
CHEK2TP53BioGRID, HPRD, MINT10673501 10710310 10724175 12810724 12897801 15862297 17157788 18833288 details
CHEK2NBNHPRD, MINT11438675 details
CHEK2MDM2BioGRID, HPRD, MINT15862297 16943424 19176998 details
CHEK2KPNA2BioGRID, HPRD, IntAct, MINT12909615 23178491 details
CHEK2CHEK2BioGRID, MINT11438675 11901158 12024051 12676583 12909615 16794575 18239682 23178491 25361978 details
CHEK2AATFBioGRID, HPRD, IntAct17157788 details
CHEK2PLK1BioGRID, DIP, HPRD, IntAct10973490 11901158 12024051 12242661 12493754 20126263 details
CHEK2BRCA1BioGRID, HPRD, IntAct10724175 12049740 12111733 12438214 17380128 17525332 18804494 26121674 details
CHEK2RB1BioGRID, MINT17380128 details
CHEK2PPP2R5EBioGRID, HPRD, IntAct15380617 details
CHEK2PPP2R5ABioGRID, HPRD, IntAct15380617 details
CHEK2PPP2R5BBioGRID, HPRD, IntAct15380617 details
CHEK2PPP2R5CBioGRID, HPRD, IntAct15380617 23178491 details
CHEK2PPP2R5DBioGRID, HPRD, IntAct15380617 details
CHEK2STRAPBioGRID, MINT18833288 details
CHEK2XRCC1MINT18971944 details
CHEK2ARHGAP1BioGRID, IntAct21988832 details
CHEK2POLR2LBioGRID, IntAct21988832 details
CHEK2NR4A1BioGRID, IntAct21988832 details
CHEK2SRPK1BioGRID, IntAct23602568 details
CHEK2GNASBioGRID, MINT25640309 details
CHEK2BAALCBioGRID, MINT25640309 details
CHEK2ENO1BioGRID, MINT25640309 details
CHEK2STMN1BioGRID, MINT25640309 details
CHEK2HMGN1BioGRID, MINT25640309 details
CHEK2SLC25A6BioGRID, MINT25640309 details
CHEK2PRMT2BioGRID, MINT25640309 details
CHEK2TLR3BioGRID, MINT25640309 details
CHEK2BEX1BioGRID, MINT25640309 details
CHEK2CCL5BioGRID, MINT25640309 details
CHEK2CDH13BioGRID, MINT25640309 details
CHEK2CYP17A1BioGRID, MINT25640309 details
CHEK2DIRAS3BioGRID, MINT25640309 details
CHEK2LRATD2BioGRID, MINT25640309 details
CHEK2HOXC6BioGRID, MINT25640309 details
CHEK2IL24BioGRID, MINT25640309 details
CHEK2ITIH5BioGRID, MINT25640309 details
CHEK2KLK9BioGRID, MINT25640309 details
CHEK2KLK7BioGRID, MINT25640309 details
CHEK2LYPD3BioGRID, MINT25640309 details
CHEK2PRDM14BioGRID, MINT25640309 details
CHEK2PSMC3IPBioGRID, MINT25640309 details
CHEK2RHOBTB2BioGRID, MINT25640309 details
CHEK2RNF20BioGRID, MINT25640309 details
CHEK2ST14BioGRID, MINT25640309 details
CHEK2NSD3BioGRID, MINT25640309 details
CHEK2CDK11AIntAct23178491 details
CHEK2PPP2CABioGRID, IntAct15380617 16596250 23178491 26083323 details
CHEK2RNF8BioGRID, DIP22266820 details
CHEK2MSH2BioGRID, HPRD12447371 15647386 details
CHEK2MDC1BioGRID, HPRD12475977 12551934 12607004 details
CHEK2PLK3BioGRID, HPRD10973490 11901158 12242661 12493754 12548019 details
CHEK2BRCA2BioGRID14623252 17525332 18317453 details
CHEK2MUS81BioGRID, HPRD11073977 11741546 details
CHEK2MDM4BioGRID, HPRD16163388 details
CHEK2FOXM1BioGRID17101782 details
CHEK2ATRBioGRID, HPRD10973490 11715017 12024051 12493754 17035231 9857181 details
CHEK2CDC25CBioGRID, HPRD10557092 10744722 11053450 11333986 11438675 11551930 12024051 12402044 12897801 12909615 16311512 16705183 25361978 28094252 9278512 details
CHEK2REV3LBioGRID18622427 details
CHEK2ATMBioGRID, HPRD10713094 10744722 10973490 11901158 12024051 12242661 12493754 15064416 15790808 16794575 20010693 details
CHEK2PPP2R2BBioGRID, HPRD15380617 16596250 details
CHEK2ELAVL1BioGRID17317627 19322201 details
CHEK2PSME3BioGRID19556897 25361978 details
CHEK2LATS2BioGRID21118956 details
CHEK2PMLBioGRID12402044 details
CHEK2DAPK3BioGRID15001356 details
CHEK2APPBioGRID21832049 details
CHEK2RCHY1BioGRID23449389 details
CHEK2VHLBioGRID22071692 details
CHEK2PRKDCBioGRID10713094 17171639 details
CHEK2SRPK2BioGRID26167880 details
CHEK2SIAH2BioGRID26751770 details
CHEK2NFKB1BioGRID21466675 details
CHEK2PPM1DBioGRID16311512 28027003 details
CHEK2CDKN1ABioGRID12897801 details
CHEK2FHL1BioGRID28094252 details
CHEK2FHL3BioGRID28094252 details
CHEK2CDK11BBioGRID23178491 details
CHEK2MAPTBioGRID20159774 details
CHEK2USP39BioGRID30771428 details
CHEK2PPP2R2AHPRD15380617 details
CHEK2DBF4HPRD12441400 details
CHEK2MRC1HPRD11715017 details
CHEK2VCPBioGRID, IntAct17525332 29599191 details
CHEK2GINS2BioGRID, IntAct17525332 details
CHEK2PER3BioGRID, MINT21070773 details
CHEK2PPP2R1ABioGRID, IntAct15380617 23178491 details
CHEK2TRIM28BioGRID22496453 details
CHEK2KAT2BBioGRID19176998 details
CHEK2UBR5BioGRID17074762 details
CHEK2CUL4ABioGRID23109433 details
CHEK2CUL1BioGRID23109433 details
CHEK2SIRT1BioGRID25361978 details
CHEK2CCAR2BioGRID25361978 details
CHEK2CNTN2BioGRID15107832 details
CHEK2FHL2BioGRID28094252 details
CHEK2LMO1BioGRID28094252 details
CHEK2LMO2BioGRID28094252 details
CHEK2LMO3BioGRID28094252 details
CHEK2E2F1HPRD12717439 details
CHEK2RAD9AHPRD12049741 details
CHEK2TSSK1BHPRD12556502 details
CHEK2ASF1AHPRD11172707 details
CHEK2ERCC6HPRD9450932 details
CHEK2RAD50BioGRID, IntAct17525332 details
CHEK2TP53BP1BioGRID, IntAct17525332 details
CHEK2PKMBioGRID, IntAct23178491 24606918 details
CHEK2FOSBioGRID, MINT25609649 details
CHEK2FOXK1BioGRID, MINT25609649 details
CHEK2FOXK2BioGRID, MINT25609649 details
CHEK2PCBP2BioGRID, IntAct23178491 details
CHEK2EIF3ABioGRID, IntAct23178491 details
CHEK2EEF1DBioGRID, IntAct23178491 details
CHEK2GTF2IBioGRID, IntAct23178491 details
CHEK2SMC2BioGRID, IntAct23178491 details
CHEK2RUVBL1BioGRID, IntAct23178491 details
CHEK2FARSABioGRID, IntAct23178491 details
CHEK2AP1B1BioGRID, IntAct23178491 details
CHEK2PRPF40ABioGRID, IntAct23178491 details
CHEK2FBXO22BioGRID, IntAct23178491 details
CHEK2PPM1GBioGRID, IntAct23178491 details
CHEK2DHX9BioGRID, IntAct23178491 details
CHEK2RBM25BioGRID, IntAct23178491 details
CHEK2SF3B3BioGRID, IntAct23178491 details
CHEK2CSNK2A2BioGRID, IntAct23178491 details
CHEK2UBR4BioGRID, IntAct23178491 details
CHEK2SF3B1BioGRID, IntAct23178491 details
CHEK2USP7BioGRID, IntAct23178491 details
CHEK2LRRC8ABioGRID, IntAct23178491 details
CHEK2CSNK2A1BioGRID, IntAct23178491 details
CHEK2SYNCRIPBioGRID, IntAct23178491 details
CHEK2XRCC5BioGRID, IntAct23178491 details
CHEK2FKBP4BioGRID, IntAct23178491 details
CHEK2TARDBPBioGRID, IntAct23178491 details
CHEK2SFPQBioGRID, IntAct23178491 details
CHEK2UBE2OBioGRID, IntAct23178491 details
CHEK2PUF60BioGRID, IntAct23178491 details
CHEK2EFTUD2BioGRID, IntAct23178491 details
CHEK2MCM5BioGRID, IntAct23178491 details
CHEK2PCBP1BioGRID, IntAct23178491 details
CHEK2HNRNPABBioGRID, IntAct23178491 details
CHEK2EEF1GBioGRID, IntAct23178491 details
CHEK2MCM3BioGRID, IntAct23178491 details
CHEK2KPNB1BioGRID, IntAct23178491 details
CHEK2BUB3BioGRID, IntAct23178491 details
CHEK2SMC4BioGRID, IntAct23178491 details
CHEK2NONOBioGRID, IntAct23178491 details
CHEK2TPRBioGRID, IntAct23178491 details
CHEK2SMC3BioGRID, IntAct23178491 details
CHEK2MCM7BioGRID, IntAct23178491 details
CHEK2SF3B2BioGRID, IntAct23178491 details
CHEK2PAICSBioGRID, IntAct23178491 details
CHEK2HNRNPKBioGRID, IntAct23178491 details
CHEK2LMNB1BioGRID, IntAct23178491 details
CHEK2HNRNPUBioGRID, IntAct23178491 details
CHEK2SMC1ABioGRID, IntAct23178491 details
CHEK2MYBBP1ABioGRID, IntAct23178491 details
CHEK2TP63BioGRID, IntAct28514442 details
CHEK2TEX264BioGRID, IntAct26186194 28514442 details
CHEK2ILKAPBioGRID26344197 details
CHEK2MAPK1BioGRID26344197 details
CHEK2MAPK3BioGRID26344197 details
CHEK2UBE2MBioGRID28581483 details
CHEK2MXI1BioGRID29507620 details
CHEK2PLEKHA4BioGRID31091453 details
CHEK2CICBioGRID29844126 details