Entity Details

Primary name REST_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13127
EntryNameREST_HUMAN
FullNameRE1-silencing transcription factor
TaxID9606
Evidenceevidence at protein level
Length1097
SequenceStatuscomplete
DateCreated2006-12-12
DateModified2021-06-02

Ontological Relatives

GenesREST

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001666 response to hypoxia
GO:0002931 response to ischemia
GO:0003682 chromatin binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0008134 transcription factor binding
GO:0008285 negative regulation of cell population proliferation
GO:0010468 regulation of gene expression
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0017053 transcription repressor complex
GO:0032348 negative regulation of aldosterone biosynthetic process
GO:0035019 somatic stem cell population maintenance
GO:0035690 cellular response to drug
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043922 negative regulation by host of viral transcription
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045955 negative regulation of calcium ion-dependent exocytosis
GO:0046676 negative regulation of insulin secretion
GO:0046872 metal ion binding
GO:0050768 negative regulation of neurogenesis
GO:0050885 neuromuscular process controlling balance
GO:0050910 detection of mechanical stimulus involved in sensory perception of sound
GO:0060088 auditory receptor cell stereocilium organization
GO:0060379 cardiac muscle cell myoblast differentiation
GO:0070933 histone H4 deacetylation
GO:0071257 cellular response to electrical stimulus
GO:0071385 cellular response to glucocorticoid stimulus
GO:0097150 neuronal stem cell population maintenance
GO:0099563 modification of synaptic structure
GO:1902459 positive regulation of stem cell population maintenance
GO:1903203 regulation of oxidative stress-induced neuron death
GO:1903204 negative regulation of oxidative stress-induced neuron death
GO:1903223 positive regulation of oxidative stress-induced neuron death
GO:2000065 negative regulation of cortisol biosynthetic process
GO:2000678 negative regulation of transcription regulatory region DNA binding
GO:2000706 negative regulation of dense core granule biogenesis
GO:2000740 negative regulation of mesenchymal stem cell differentiation
GO:2000798 negative regulation of amniotic stem cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR013087 Zinc finger C2H2-typeDomainDomain
IPR027757 RE1-silencing transcription factorFamilyFamily
IPR036236 Zinc finger C2H2 superfamilyFamilyHomologous superfamily

Diseases

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Interactions

43 interactions

InteractorPartnerSourcesPublicationsLink
REST_HUMANRCOR1_HUMANBioGRID, DIP, HPRD10449787 15897453 17939992 25197063 details
REST_HUMANFBW1A_HUMANBioGRID, DIP18354482 18354483 24760862 25197063 25299066 25453754 25515538 33038663 details
REST_HUMANHDAC1_HUMANBioGRID10491605 18806873 details
REST_HUMANCDYL_HUMANBioGRID19061646 details
REST_HUMANTBP_HUMANBioGRID15197246 details
REST_HUMANTF2B_HUMANBioGRID15197246 details
REST_HUMANSIN3B_HUMANBioGRID, HPRD10570134 15197246 details
REST_HUMANTCP4_HUMANBioGRID20080105 details
REST_HUMANPLK1_HUMANBioGRID25453754 details
REST_HUMANMK01_HUMANBioGRID25197063 details
REST_HUMANAURKA_HUMANBioGRID28218735 details
REST_HUMANSMCE1_HUMANBioGRID, IntAct12192000 details
REST_HUMANSMCA4_HUMANBioGRID, IntAct12192000 17023429 details
REST_HUMANSMRC2_HUMANBioGRID, IntAct12192000 details
REST_HUMANKDM5C_HUMANBioGRID, DIP17468742 details
REST_HUMANEHMT2_HUMANBioGRID, DIP15200951 17468742 details
REST_HUMANFBW1B_HUMANBioGRID, DIP18354482 18354483 22017875 24500709 25332235 25515538 25900982 details
REST_HUMANHDAC5_HUMANBioGRID17011572 27976729 details
REST_HUMANHDAC4_HUMANBioGRID17011572 details
REST_HUMANSP1_HUMANBioGRID15528196 details
REST_HUMANSIN3A_HUMANBioGRID10491605 21693630 details
REST_HUMANGRIA2_HUMANBioGRID21948504 details
REST_HUMANTERF2_HUMANBioGRID18818083 details
REST_HUMANFBXW2_HUMANBioGRID18354482 details
REST_HUMANFBXW4_HUMANBioGRID18354482 details
REST_HUMANFBXW5_HUMANBioGRID18354482 details
REST_HUMANFBXW8_HUMANBioGRID18354482 details
REST_HUMANFBXW7_HUMANBioGRID18354482 details
REST_HUMANKC1E_HUMANBioGRID24760862 details
REST_HUMANUBC_HUMANBioGRID18818083 details
REST_HUMANTEX14_HUMANBioGRID25453754 details
REST_HUMANSCYL1_HUMANBioGRID25453754 details
REST_HUMANPIN1_HUMANBioGRID25197063 details
REST_HUMANCTDS1_HUMANBioGRID25197063 details
REST_HUMANFOXK2_HUMANBioGRID27773593 details
REST_HUMANMDM2_HUMANBioGRID27004407 details
REST_HUMANTHOC4_HUMANBioGRID27976729 details
REST_HUMANNUCL_HUMANBioGRID27976729 details
REST_HUMANHNRPQ_HUMANBioGRID27976729 details
REST_HUMANNPM_HUMANBioGRID27976729 details
REST_HUMANPARP1_HUMANBioGRID27976729 details
REST_HUMANTIF1B_HUMANBioGRID27976729 details
REST_HUMANHD_HUMANHPRD12881722 details