Entity Details

Primary name ERCC8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ13216
EntryNameERCC8_HUMAN
FullNameDNA excision repair protein ERCC-8
TaxID9606
Evidenceevidence at protein level
Length396
SequenceStatuscomplete
DateCreated1998-07-15
DateModified2021-06-02

Ontological Relatives

GenesERCC8

GO terms

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GOName
GO:0000012 single strand break repair
GO:0000109 nucleotide-excision repair complex
GO:0000209 protein polyubiquitination
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006974 cellular response to DNA damage stimulus
GO:0006979 response to oxidative stress
GO:0009411 response to UV
GO:0010165 response to X-ray
GO:0010996 response to auditory stimulus
GO:0014070 response to organic cyclic compound
GO:0016363 nuclear matrix
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0032508 DNA duplex unwinding
GO:0032991 protein-containing complex
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043204 perikaryon
GO:0043687 post-translational protein modification
GO:0044877 protein-containing complex binding
GO:0045739 positive regulation of DNA repair
GO:0051865 protein autoubiquitination
GO:0080008 Cul4-RING E3 ubiquitin ligase complex
GO:0097680 double-strand break repair via classical nonhomologous end joining

Subcellular Location

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Subcellular Location
Nucleus
Nucleus matrix

Domains

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DomainNameCategoryType
IPR001680 WD40 repeatRepeatRepeat
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR019775 WD40 repeat, conserved siteSiteConserved site
IPR020472 G-protein beta WD-40 repeatRepeatRepeat
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily
IPR042238 DNA excision repair protein Rad28/ERCC8/Ckn1/ATCSA-1FamilyFamily

Diseases

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Interactions

54 interactions

InteractorPartnerSourcesPublicationsLink
ERCC8_HUMANSYF1_HUMANBioGRID, HPRD, IntAct10944529 details
ERCC8_HUMANCBR1_HUMANHPRD, IntAct16169070 details
ERCC8_HUMANQCR8_HUMANHPRD, IntAct16169070 details
ERCC8_HUMANERCC6_HUMANBioGRID, HPRD, IntAct16751180 16916636 20541997 22032989 22902626 26826127 29225035 29531219 31970402 32355176 7664335 details
ERCC8_HUMANTF2H2_HUMANBioGRID, HPRD, IntAct7664335 details
ERCC8_HUMANCSK2B_HUMANBioGRID, MINT21900206 details
ERCC8_HUMANCUL4A_HUMANBioGRID, IntAct12732143 16751180 16949367 21145461 22902626 26826127 29225035 29531219 31973889 details
ERCC8_HUMANCUL4B_HUMANBioGRID, IntAct21145461 22902626 26496610 29531219 31973889 details
ERCC8_HUMANWDR61_HUMANIntAct32814053 details
ERCC8_HUMANNACAD_HUMANIntAct32814053 details
ERCC8_HUMANPIAS1_HUMANIntAct32814053 details
ERCC8_HUMANCSN3_HUMANBioGRID, IntAct12732143 19295130 29531219 32814053 details
ERCC8_HUMANRN183_HUMANIntAct32814053 details
ERCC8_HUMANGFAP_HUMANIntAct32814053 details
ERCC8_HUMANPRPS1_HUMANIntAct32814053 details
ERCC8_HUMANKIF1B_HUMANIntAct32814053 details
ERCC8_HUMANHTRA2_HUMANIntAct32814053 details
ERCC8_HUMANJPH3_HUMANIntAct32814053 details
ERCC8_HUMANATX1_HUMANIntAct32814053 details
ERCC8_HUMANDDB1_HUMANBioGRID, HPRD12732143 16751180 16949367 17392787 22232169 22902626 26826127 28416769 29531219 31970402 details
ERCC8_HUMANERPG3_HUMANBioGRID16751180 16916636 20541997 22032989 22902626 26826127 29225035 29531219 31970402 32355176 7664335 details
ERCC8_HUMANRBX1_HUMANBioGRID12732143 16751180 29531219 details
ERCC8_HUMANTOP1_HUMANBioGRID12549820 details
ERCC8_HUMANKCC2D_HUMANBioGRID26871637 details
ERCC8_HUMANCSN5_HUMANBioGRID, IntAct12732143 16751180 19615732 21145461 29531219 details
ERCC8_HUMANCSN6_HUMANBioGRID, IntAct12732143 19295130 19615732 21145461 29531219 details
ERCC8_HUMANRPB1_HUMANBioGRID16916636 32355176 details
ERCC8_HUMANEP300_HUMANBioGRID16916636 details
ERCC8_HUMANHMGN1_HUMANBioGRID16916636 details
ERCC8_HUMANDDB2_HUMANBioGRID12732143 details
ERCC8_HUMANCSN1_HUMANBioGRID12732143 details
ERCC8_HUMANCSN2_HUMANBioGRID12732143 29531219 details
ERCC8_HUMANCSN4_HUMANBioGRID12732143 19295130 29531219 details
ERCC8_HUMANCSN7A_HUMANBioGRID12732143 29531219 details
ERCC8_HUMANCSN8_HUMANBioGRID12732143 16751180 29531219 details
ERCC8_HUMANP53_HUMANBioGRID22032989 details
ERCC8_HUMANMDM2_HUMANBioGRID22032989 details
ERCC8_HUMANOGG1_HUMANBioGRID20100872 details
ERCC8_HUMANSSBP_HUMANBioGRID20100872 details
ERCC8_HUMANZNF24_HUMANBioGRID22902626 details
ERCC8_HUMANRUVB2_HUMANBioGRID22902626 details
ERCC8_HUMANUVSSA_HUMANBioGRID22902626 29323787 29531219 32355176 details
ERCC8_HUMANPCNA_HUMANBioGRID22902626 details
ERCC8_HUMANH10_HUMANBioGRID22902626 details
ERCC8_HUMANTERA_HUMANBioGRID26826127 details
ERCC8_HUMANUBXN7_HUMANBioGRID26826127 details
ERCC8_HUMANDNM1L_HUMANBioGRID29262528 details
ERCC8_HUMANTCPA_HUMANBioGRID29531219 details
ERCC8_HUMANTCPD_HUMANBioGRID29531219 details
ERCC8_HUMANTCPE_HUMANBioGRID29531219 details
ERCC8_HUMANATF3_HUMANBioGRID29225035 details
ERCC8_HUMANPSMD1_HUMANBioGRID29225035 details
ERCC8_HUMANPSB5_HUMANBioGRID29225035 details
ERCC8_HUMANNUCL_HUMANBioGRID31970402 details